YEARS

2007-2013

AUTHORS

Marcella Donovan Walker

TITLE

Aspects of Bone Quality Among Chinese American Women

ABSTRACT

DESCRIPTION (provided by applicant): Although osteoporosis is most common among Caucasian postmenopausal women, it is not infrequent among non-Caucasian women, particularly Chinese and Chinese American women. Chinese Americans are a growing population at risk for osteoporosis. The US Census Bureau estimates by 2050, one-tenth of the US population will be of Asian descent, many Chinese American. Osteoporosis is clearly an important public health problem among Chinese Americans. However, most epidemiologic data that relates bone mineral density (BMD) to fracture risk has been acquired among postmenopausal Caucasian women and it is, thus, only for this group that the densitometric definition of osteoporosis and treatment guidelines strictly apply. It s not known how BMD relates to fracture risk in the Chinese population nor what T-score accurately describes the population at risk. In the absence of prospective data, the T-score definition of osteoporosis or postmenopausal Caucasian women has been applied to other racial groups. Moreover, a Caucasian BMD referent database is used to assess fracture risk among Asian women. It is becoming increasingly apparent that racial differences in BMD and fracture risk make application of this definition and the Caucasian database problematic. For example, Chinese women in Asia and the US have a significantly lower rate of hip fracture than Caucasian women, despite the fact that areal BMD is lower among Chinese women. These findings suggest that the relationship between BMD and fracture risk may differ among Caucasian and Chinese women. The overall goal of this proposal is to characterize areal bone density as well as other aspects of bone quality, such as volumetric density, bone size, bone microarchitecture, remodeling, mineralization density, hydroxyapetite crystal size and matrix properties among Chinese American women. Comparing these new data to that of Caucasian women may provide insight into how, despite lower BMD, Chinese women are seemingly protected against hip fracture. This new knowledge may permit fracture risk to be more accurately determined among Chinese American women and may allow for the development of diagnostic and treatment guidelines that are directly relevant to the Chinese American population. This project will, in addition, enable me to acquire both the technical and research methodological skills necessary to develop into an independent investigator in metabolic bone disease.

FUNDED PUBLICATIONS

  • Differences in bone microarchitecture between postmenopausal Chinese-American and white women.
  • A referent bone mineral density database for Chinese American women
  • A referent bone mineral density database for Chinese American women.
  • Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white women.
  • A trabecular plate-like phenotype is overrepresented in Chinese-American versus Caucasian women.
  • Cardiovascular aspects of primary hyperparathyroidism.
  • Lower cortical porosity and higher tissue mineral density in Chinese American versus white women.
  • Circulating sclerostin levels and markers of bone turnover in Chinese-American and white women.
  • Determinants of bone mineral density in Chinese-American women
  • Determinants of bone mineral density in Chinese-American women.
  • Trabecular bone score is associated with volumetric bone density and microarchitecture as assessed by central QCT and HRpQCT in Chinese American and white women.
  • Premenopausal and postmenopausal differences in bone microstructure and mechanical competence in Chinese-American and white women.
  • Volumetric bone mineral density at the spine and hip in Chinese American and White women
  • A trabecular plate-like phenotype is overrepresented in Chinese-American versus Caucasian women
  • Application of high-resolution skeletal imaging to measurements of volumetric BMD and skeletal microarchitecture in Chinese-American and white women: explanation of a paradox.
  • Volumetric bone mineral density at the spine and hip in Chinese American and White women.
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    30 sg:title Aspects of Bone Quality Among Chinese American Women
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