YEARS

2006-2011

AUTHORS

Lillian S Kao

TITLE

Studies on Hyperglycemia in Surgical Infection

ABSTRACT

DESCRIPTION (provided by applicant): The primary goal of the career development activities described in this proposal is for Dr. Lillian Kao, an academic general surgeon, to acquire the knowledge, skills, and experience required to conduct high quality patient-oriented research, particularly studies of perioperative infections and multicenter clinical trials of interventions that cannot be adequately evaluated within a single center. The University of Texas-Houston provides extensive resources to the candidate including the Clinical Research Curriculum and Mentorship Program, the Masters Degree Program in Clinical Research, the General Center for Clinical Research, and a large, heterogeneous surgical population. The specific aims of the proposal are: (1) to complete a Master's Degree in Clinical Research focused on her research goals;(2) to receive intensive mentoring from a dedicated team that is led by Kevin Lally, one of only a few surgeons to have successfully organized and directed multicenter trials, and that includes faculty well known for their expertise in inflammatory mediators and hyperglycemia in surgical patients (David Mercer, Steven Wolf);and (3) to conduct a 2-center explanatory trial as the first trial of strict glycemic control for surgical patients with necrotizing soft tissue infection (NSTI), The primary objective is to verify feasibility of the intervention, provide unbiased and evidence-based estimates of treatment effects, and obtain data needed for Dr. Kao to design and direct a larger multicenter trial if necessary. The 2-center trial (n >100) will have adequate power to identify a 30% difference in favorable outcome defined as discharge alive from the hospital without an amputation in less than the median number of hospital days. Secondary objectives include evaluation of specific hypotheses relating the intervention to cytokine and neutrophil responses. These preliminary data will provide the basis for future research and grant applications, lend insight into the mechanisms by which hyperglycemia results in adverse effects, and improve outcome through the development of evidence-based therapeutic strategies for patient care.

FUNDED PUBLICATIONS

  • Clinical research methodology I: introduction to randomized trials.
  • Should perioperative supplemental oxygen be routinely recommended for surgery patients? A Bayesian meta-analysis.
  • Reliability of superficial surgical site infections as a hospital quality measure.
  • Local variations in the epidemiology, microbiology, and outcome of necrotizing soft-tissue infections: a multicenter study.
  • Peri-operative glycaemic control regimens for preventing surgical site infections in adults.
  • Analysis of variance: is there a difference in means and what does it mean?
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    23 TRIPLES      17 PREDICATES      24 URIs      9 LITERALS

    Subject Predicate Object
    1 grants:d3b4ded68d6d3392356c4ef51f30bc8d sg:abstract DESCRIPTION (provided by applicant): The primary goal of the career development activities described in this proposal is for Dr. Lillian Kao, an academic general surgeon, to acquire the knowledge, skills, and experience required to conduct high quality patient-oriented research, particularly studies of perioperative infections and multicenter clinical trials of interventions that cannot be adequately evaluated within a single center. The University of Texas-Houston provides extensive resources to the candidate including the Clinical Research Curriculum and Mentorship Program, the Masters Degree Program in Clinical Research, the General Center for Clinical Research, and a large, heterogeneous surgical population. The specific aims of the proposal are: (1) to complete a Master's Degree in Clinical Research focused on her research goals;(2) to receive intensive mentoring from a dedicated team that is led by Kevin Lally, one of only a few surgeons to have successfully organized and directed multicenter trials, and that includes faculty well known for their expertise in inflammatory mediators and hyperglycemia in surgical patients (David Mercer, Steven Wolf);and (3) to conduct a 2-center explanatory trial as the first trial of strict glycemic control for surgical patients with necrotizing soft tissue infection (NSTI), The primary objective is to verify feasibility of the intervention, provide unbiased and evidence-based estimates of treatment effects, and obtain data needed for Dr. Kao to design and direct a larger multicenter trial if necessary. The 2-center trial (n >100) will have adequate power to identify a 30% difference in favorable outcome defined as discharge alive from the hospital without an amputation in less than the median number of hospital days. Secondary objectives include evaluation of specific hypotheses relating the intervention to cytokine and neutrophil responses. These preliminary data will provide the basis for future research and grant applications, lend insight into the mechanisms by which hyperglycemia results in adverse effects, and improve outcome through the development of evidence-based therapeutic strategies for patient care.
    2 sg:endYear 2011
    3 sg:fundingAmount 674840.0
    4 sg:fundingCurrency USD
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    16 sg:language English
    17 sg:license http://scigraph.springernature.com/explorer/license/
    18 sg:scigraphId d3b4ded68d6d3392356c4ef51f30bc8d
    19 sg:startYear 2006
    20 sg:title Studies on Hyperglycemia in Surgical Infection
    21 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=7862529
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    23 rdfs:label Grant: Studies on Hyperglycemia in Surgical Infection
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