YEARS

2010-2014

AUTHORS

Sharon Antonucci

TITLE

SEMANTIC FEATURE PROCESSING IN INDIVIDUALS WITH STROKE APHASIA

ABSTRACT

DESCRIPTION (provided by applicant): Word retrieval difficulty is the most common symptom observed in people with aphasia, having a profound impact on individuals' ability to communicate in daily life. While it has long been acknowledged that adequate processing of meaning or semantic knowledge is a necessary precursor to accurate word retrieval, it remains unclear how deficient processing of semantic knowledge influences word retrieval difficulties observed in aphasia. The long-term goal is to design semantically-based treatments for word retrieval impairment in aphasia that maximize the types of semantic information that are utilized to facilitate word retrieval. The overall objective of this project is to determine the relationships among semantic feature knowledge, word retrieval deficits, and lesion location in individuals with aphasia. The central hypothesis is that (1) deficient processing of specific semantic feature cues will differentially impact word retrieval for concepts whose meanings are weighted in favor of those features; and (2) deficient semantic feature/concept processing is associated with lesion location. The rationale for the proposed project is that understanding the relationship between semantic knowledge and word retrieval impairment in aphasia will provide the foundation upon which to expand clinical research into theoretically-motivated assessment and treatment of deficient semantically-guided lexical retrieval. The central hypothesis will be tested by pursuing the following two specific aims: (1) Determine the association between semantic feature cues and word retrieval for different types of object concepts, and (2) Determine the extent to which semantic feature/concept processing is associated with lesion location in aphasia. To pursue these specific aims, individuals with aphasia will be assessed using a neuropsychological battery designed to provide for direct comparison between feature types within the same living and nonliving objects. High resolution MRI scans will be collected for participants with aphasia and behavioral performance will be related to lesion location. Once this information has been obtained, it will be possible to differentiate patterns of performance and discern the extent to which semantic feature treatments may be tailored to meet the needs of individuals with differing underlying mechanisms of word retrieval impairment. Furthermore, identifying the interaction between semantic feature and object concept processing will inform ongoing theoretical debates regarding whether impairment to processing of different types of object concepts is an emergent property of feature-processing deficits that can be linked to lesion location. PUBLIC HEALTH RELEVANCE: The proposed research will have an important positive impact on understanding of how best to design theoretically-motivated clinical tools to remediate word retrieval impairment based on knowledge of individuals' ability to process semantic feature cues. The proposed project has relevance to public health because the mechanisms to be investigated will inform the development of assessments and treatments for word retrieval impairments that can compromise communication in the daily lives of individuals with aphasia.

FUNDED PUBLICATIONS

  • A lifespan perspective on semantic processing of concrete concepts: does a sensory/motor model have the potential to bridge the gap?
  • A lifespan perspective on semantic processing of concrete concepts: does a sensory/motor model have the potential to bridge the gap?
  • How to use: Click on a object to move its position. Double click to open its homepage. Right click to preview its contents.

    Download the RDF metadata as:   json-ld nt turtle xml License info


    21 TRIPLES      17 PREDICATES      22 URIs      9 LITERALS

    Subject Predicate Object
    1 grants:ce740004663ad5e08080f5f22f49fe42 sg:abstract DESCRIPTION (provided by applicant): Word retrieval difficulty is the most common symptom observed in people with aphasia, having a profound impact on individuals' ability to communicate in daily life. While it has long been acknowledged that adequate processing of meaning or semantic knowledge is a necessary precursor to accurate word retrieval, it remains unclear how deficient processing of semantic knowledge influences word retrieval difficulties observed in aphasia. The long-term goal is to design semantically-based treatments for word retrieval impairment in aphasia that maximize the types of semantic information that are utilized to facilitate word retrieval. The overall objective of this project is to determine the relationships among semantic feature knowledge, word retrieval deficits, and lesion location in individuals with aphasia. The central hypothesis is that (1) deficient processing of specific semantic feature cues will differentially impact word retrieval for concepts whose meanings are weighted in favor of those features; and (2) deficient semantic feature/concept processing is associated with lesion location. The rationale for the proposed project is that understanding the relationship between semantic knowledge and word retrieval impairment in aphasia will provide the foundation upon which to expand clinical research into theoretically-motivated assessment and treatment of deficient semantically-guided lexical retrieval. The central hypothesis will be tested by pursuing the following two specific aims: (1) Determine the association between semantic feature cues and word retrieval for different types of object concepts, and (2) Determine the extent to which semantic feature/concept processing is associated with lesion location in aphasia. To pursue these specific aims, individuals with aphasia will be assessed using a neuropsychological battery designed to provide for direct comparison between feature types within the same living and nonliving objects. High resolution MRI scans will be collected for participants with aphasia and behavioral performance will be related to lesion location. Once this information has been obtained, it will be possible to differentiate patterns of performance and discern the extent to which semantic feature treatments may be tailored to meet the needs of individuals with differing underlying mechanisms of word retrieval impairment. Furthermore, identifying the interaction between semantic feature and object concept processing will inform ongoing theoretical debates regarding whether impairment to processing of different types of object concepts is an emergent property of feature-processing deficits that can be linked to lesion location. PUBLIC HEALTH RELEVANCE: The proposed research will have an important positive impact on understanding of how best to design theoretically-motivated clinical tools to remediate word retrieval impairment based on knowledge of individuals' ability to process semantic feature cues. The proposed project has relevance to public health because the mechanisms to be investigated will inform the development of assessments and treatments for word retrieval impairments that can compromise communication in the daily lives of individuals with aphasia.
    2 sg:endYear 2014
    3 sg:fundingAmount 408604.0
    4 sg:fundingCurrency USD
    5 sg:hasContribution contributions:5f918bedb2cc7a3f135d30b235392998
    6 sg:hasFieldOfResearchCode anzsrc-for:11
    7 anzsrc-for:1103
    8 anzsrc-for:17
    9 anzsrc-for:1701
    10 sg:hasFundedPublication articles:062704154d1034bb30e17e57ebeb9f3d
    11 articles:09fbc8874089c5118c58f29e5c6fd28e
    12 sg:hasFundingOrganization grid-institutes:grid.214431.1
    13 sg:hasRecipientOrganization grid-institutes:grid.268324.9
    14 sg:language English
    15 sg:license http://scigraph.springernature.com/explorer/license/
    16 sg:scigraphId ce740004663ad5e08080f5f22f49fe42
    17 sg:startYear 2010
    18 sg:title SEMANTIC FEATURE PROCESSING IN INDIVIDUALS WITH STROKE APHASIA
    19 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=8636526
    20 rdf:type sg:Grant
    21 rdfs:label Grant: SEMANTIC FEATURE PROCESSING IN INDIVIDUALS WITH STROKE APHASIA
    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular JSON format for linked data.

    curl -H 'Accept: application/ld+json' 'http://scigraph.springernature.com/things/grants/ce740004663ad5e08080f5f22f49fe42'

    N-Triples is a line-based linked data format ideal for batch operations .

    curl -H 'Accept: application/n-triples' 'http://scigraph.springernature.com/things/grants/ce740004663ad5e08080f5f22f49fe42'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'http://scigraph.springernature.com/things/grants/ce740004663ad5e08080f5f22f49fe42'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'http://scigraph.springernature.com/things/grants/ce740004663ad5e08080f5f22f49fe42'






    Preview window. Press ESC to close (or click here)


    ...