YEARS

2002-2008

AUTHORS

Arthur Wingfield

TITLE

Word retrieval in aphasia

ABSTRACT

DESCRIPTION (provided by applicant): The focus of this research is the study of the brain mechanisms in word retrieval in normal speakers as revealed by their disruption in aphasia, where these mechanisms have become damaged or dissociated. Following an examination of perceptual competition on naming objects in fluent and nonfluent aphasia, the first of a series of experiments addresses the problem of dissociation of noun and verb impairments in Broca's aphasia by adopting Luria's distinction between predicative and nominal modes of speech. The possibility is investigated that this distinction may underlie this commonly observed dissociation. The next stage of this investigation examines the role of semantic memory in word retrieval by examining patients' competence in identifying the properties of objects to be named and comparing this ability with their success in retrieving the names of these objects. The third question in the research focuses on the stages of phonological activation and implementation in word production. A model is proposed to identify the multi-staged nature of phonological activation. Predicted differences in speed of naming following from immediate versus delayed priming of picture names will be tested with the goal of distinguishing between the effects of early and late stages of phonological activation. Finally, a series of three studies using the "gating" technique examines the differences between Broca's and Wernicke's aphasics by comparing their response to priming with word onsets and with the prosody (stress pattern and duration) of target words. This research program promises clinical insights that will be useful in the differential diagnosis of aphasia as well as making theoretical contributions to understanding the mechanisms of word production and phonological realization.

FUNDED PUBLICATIONS

  • Theory of mind and the right cerebral hemisphere: refining the scope of impairment.
  • Effects of syntactic features on sentence-picture matching in Broca's aphasics: a reply to Drai and Grodzinksy (2005).
  • Inference of beliefs and emotions in patients with Alzheimer's disease.
  • Treatment of metaphor interpretation deficits subsequent to traumatic brain injury.
  • Treating Metaphor Interpretation Deficits Subsequent to Right Hemisphere Brain Damage: Preliminary Results.
  • Language and the aging brain: patterns of neural compensation revealed by functional brain imaging.
  • Variable solutions to the same problem: aberrant practice effects in object naming by three aphasic patients.
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    25 TRIPLES      17 PREDICATES      26 URIs      9 LITERALS

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    1 grants:bf4722bb9d31b6f017b3ca533cb16f49 sg:abstract DESCRIPTION (provided by applicant): The focus of this research is the study of the brain mechanisms in word retrieval in normal speakers as revealed by their disruption in aphasia, where these mechanisms have become damaged or dissociated. Following an examination of perceptual competition on naming objects in fluent and nonfluent aphasia, the first of a series of experiments addresses the problem of dissociation of noun and verb impairments in Broca's aphasia by adopting Luria's distinction between predicative and nominal modes of speech. The possibility is investigated that this distinction may underlie this commonly observed dissociation. The next stage of this investigation examines the role of semantic memory in word retrieval by examining patients' competence in identifying the properties of objects to be named and comparing this ability with their success in retrieving the names of these objects. The third question in the research focuses on the stages of phonological activation and implementation in word production. A model is proposed to identify the multi-staged nature of phonological activation. Predicted differences in speed of naming following from immediate versus delayed priming of picture names will be tested with the goal of distinguishing between the effects of early and late stages of phonological activation. Finally, a series of three studies using the "gating" technique examines the differences between Broca's and Wernicke's aphasics by comparing their response to priming with word onsets and with the prosody (stress pattern and duration) of target words. This research program promises clinical insights that will be useful in the differential diagnosis of aphasia as well as making theoretical contributions to understanding the mechanisms of word production and phonological realization.
    2 sg:endYear 2008
    3 sg:fundingAmount 627039.0
    4 sg:fundingCurrency USD
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    18 sg:language English
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    20 sg:scigraphId bf4722bb9d31b6f017b3ca533cb16f49
    21 sg:startYear 2002
    22 sg:title Word retrieval in aphasia
    23 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=7021424
    24 rdf:type sg:Grant
    25 rdfs:label Grant: Word retrieval in aphasia
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