YEARS

-

AUTHORS

Bernadette R Gochuico

TITLE

Interstitial Lung Disease

ABSTRACT

Translational research projects studying interstitial lung disease examine the pathogenesis of pulmonary fibrosis within subpopulations of patients, focussing on genetic effects. Diseases of interest include sporadic and genetic subtypes of pulmonary fibrosis. Thus far, at least two hundred patients have been enrolled in four clinical research protocols (i.e., 99-HL-0056, 99-HL-0068, 99-HL-0069, 04-H-0211). Analyses of patient-derived specimens (e.g., genomic DNA, serum, plasma, bronchoalveolar lavage cells and fluid, lung tissue) are being performed to study and compare genetic polymorphisms, gene and protein expression, and clinical findings (e.g., lung physiology, chest radiography, DTPA lung clearance scan). These pulmonary fibrosis protocols have generated collaborations with several intramural and extramural investigators. High-resolution computed tomography and aerosolized DTPA lung clearance scan findings are being examined by NIH Clinical Center researchers, Drs. Nilo Avila and Clara Chen, respectively. Dr. Ronald Goldstein, Boston University, and Dr. Ivan Rosas, University of Pittsburgh, will analyze biomarkers of fibrosis. Collaborations with Dr. Jonathan Orens, Johns Hopkins University, and Dr. Steven D.

FUNDED PUBLICATIONS

  • Potential pathogenesis and clinical aspects of pulmonary fibrosis associated with rheumatoid arthritis.
  • Impairment of alveolar macrophage transcription in idiopathic pulmonary fibrosis.
  • ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.
  • Early interstitial lung disease in familial pulmonary fibrosis.
  • Atherosclerotic plaque macrophage transcriptional regulators are expressed in blood and modulated by tristetraprolin.
  • Effect of pirfenidone on the pulmonary fibrosis of Hermansky-Pudlak syndrome.
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    19 TRIPLES      13 PREDICATES      19 URIs      5 LITERALS

    Subject Predicate Object
    1 grants:bdcd2ed54849ac009f73cec3b1e9238e sg:abstract Translational research projects studying interstitial lung disease examine the pathogenesis of pulmonary fibrosis within subpopulations of patients, focussing on genetic effects. Diseases of interest include sporadic and genetic subtypes of pulmonary fibrosis. Thus far, at least two hundred patients have been enrolled in four clinical research protocols (i.e., 99-HL-0056, 99-HL-0068, 99-HL-0069, 04-H-0211). Analyses of patient-derived specimens (e.g., genomic DNA, serum, plasma, bronchoalveolar lavage cells and fluid, lung tissue) are being performed to study and compare genetic polymorphisms, gene and protein expression, and clinical findings (e.g., lung physiology, chest radiography, DTPA lung clearance scan). These pulmonary fibrosis protocols have generated collaborations with several intramural and extramural investigators. High-resolution computed tomography and aerosolized DTPA lung clearance scan findings are being examined by NIH Clinical Center researchers, Drs. Nilo Avila and Clara Chen, respectively. Dr. Ronald Goldstein, Boston University, and Dr. Ivan Rosas, University of Pittsburgh, will analyze biomarkers of fibrosis. Collaborations with Dr. Jonathan Orens, Johns Hopkins University, and Dr. Steven D.
    2 sg:hasContribution contributions:a9b0c45e69f06a21f7fdc06b05cba9d2
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    14 sg:license http://scigraph.springernature.com/explorer/license/
    15 sg:scigraphId bdcd2ed54849ac009f73cec3b1e9238e
    16 sg:title Interstitial Lung Disease
    17 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=7321601
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    19 rdfs:label Grant: Interstitial Lung Disease
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