YEARS

2005-2011

AUTHORS

Ronald Steven Stowers

TITLE

Genetic Dissection of Synaptic Transmission

ABSTRACT

DESCRIPTION (provided by applicant): The long term objectives of this project are to understand the molecular and cellular physiology of the synapse as a prerequisite for comprehending more complex aspects of nervous system function and dysfunction. This research will likely have implications for many areas of neurobiology including synaptic plasticity, information processing, behavior, addiction, neurodegeneration, and psychiatric disease. The starting point of this research is an existing collection of 13 Drosophila mutants identified on the basis of a photoreceptor synaptic transmission phenotype. Specific aims include: 1) extending phenotypic characterization to include synapse ultrastructure and neuromuscular electrophysiology, 2) molecular cloning of the genes corresponding to the most interesting mutants, and 3) determining the molecular identity and cellular functions of the corresponding proteins. The candidate for this Research Career Award, Dr. R. Steven Stowers, has previously carried out molecular and genetic studies of synaptic transmission in the labs of Drs. Thomas Schwarz and Corey Goodman. Through this award, Dr. Stowers will take advantage of the electrophysiology and optical imaging expertise of his proposed mentor, Dr. Ehud Isacoff at UC Berkeley, to better understand the nature of the defects in his synaptic transmission mutants. The training Dr. Stowers will acquire in applying these biophysical techniques to neurobiological problems will complement his already strong background in genetics and molecular and cellular biology. In addition, the workshops, seminar series, and excellent neuroscience community at UC Berkeley provide an outstanding neuroscience training environment. Through expanding and diversifying his skill set to include electrophysiology and optical imaging, Dr. Stowers will develop into a formidable, well rounded neuroscientist ideally positioned to achieve both his immediate career goal of obtaining a faculty position at a research university and his long-term career goal of making significant contributions to neurobiology.

FUNDED PUBLICATIONS

  • Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.
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    21 TRIPLES      17 PREDICATES      22 URIs      9 LITERALS

    Subject Predicate Object
    1 grants:a03be13c7439a0aec6be1de0e2d5ffb3 sg:abstract DESCRIPTION (provided by applicant): The long term objectives of this project are to understand the molecular and cellular physiology of the synapse as a prerequisite for comprehending more complex aspects of nervous system function and dysfunction. This research will likely have implications for many areas of neurobiology including synaptic plasticity, information processing, behavior, addiction, neurodegeneration, and psychiatric disease. The starting point of this research is an existing collection of 13 Drosophila mutants identified on the basis of a photoreceptor synaptic transmission phenotype. Specific aims include: 1) extending phenotypic characterization to include synapse ultrastructure and neuromuscular electrophysiology, 2) molecular cloning of the genes corresponding to the most interesting mutants, and 3) determining the molecular identity and cellular functions of the corresponding proteins. The candidate for this Research Career Award, Dr. R. Steven Stowers, has previously carried out molecular and genetic studies of synaptic transmission in the labs of Drs. Thomas Schwarz and Corey Goodman. Through this award, Dr. Stowers will take advantage of the electrophysiology and optical imaging expertise of his proposed mentor, Dr. Ehud Isacoff at UC Berkeley, to better understand the nature of the defects in his synaptic transmission mutants. The training Dr. Stowers will acquire in applying these biophysical techniques to neurobiological problems will complement his already strong background in genetics and molecular and cellular biology. In addition, the workshops, seminar series, and excellent neuroscience community at UC Berkeley provide an outstanding neuroscience training environment. Through expanding and diversifying his skill set to include electrophysiology and optical imaging, Dr. Stowers will develop into a formidable, well rounded neuroscientist ideally positioned to achieve both his immediate career goal of obtaining a faculty position at a research university and his long-term career goal of making significant contributions to neurobiology.
    2 sg:endYear 2011
    3 sg:fundingAmount 573028.0
    4 sg:fundingCurrency USD
    5 sg:hasContribution contributions:bfadf177b184f8bb8893eba03cb8fcbd
    6 sg:hasFieldOfResearchCode anzsrc-for:06
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    11 sg:hasFundedPublication articles:fb80d5b634d57f35b68d41bf5beb4566
    12 sg:hasFundingOrganization grid-institutes:grid.420090.f
    13 sg:hasRecipientOrganization grid-institutes:grid.41891.35
    14 sg:language English
    15 sg:license http://scigraph.springernature.com/explorer/license/
    16 sg:scigraphId a03be13c7439a0aec6be1de0e2d5ffb3
    17 sg:startYear 2005
    18 sg:title Genetic Dissection of Synaptic Transmission
    19 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=7993211
    20 rdf:type sg:Grant
    21 rdfs:label Grant: Genetic Dissection of Synaptic Transmission
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