YEARS

2007-2008

AUTHORS

Hilton Whittle

TITLE

Two Dose E-Z Measles Vaccine Trial: Boosting Of Immune Responses In Bissau

ABSTRACT

Millions of children are given a booster dose of measles vaccine in mass immunisation campaigns throughout the world. It is not know if the rapidity of responses, which is likely to relate to protection against measles, varies according to the number of doses of measles vaccine the children have previously been given. We will compare these responses in children who have been part of previous trial of one or two doses of measles vaccine in Guinea Bissau. Technical Summary Little is known of short term antibody responses following a booster dose of measles vaccine in immunized children. We will compare the magnitude of these responses in three year old children who have received one or two doses of Edmonston-Zagreb vaccine in infancy as part of a previous trial in Bissau. Before and two weeks after a booster dose of E-Z vaccine haemagglutinin inhibiting (HAI) antibodies will be compared in the blood of the two groups of children. Long term antibody and cytokine responses to measles antigen will be measured one year after the boost. We predict that antibody concentrations will be similar in the two groups two weeks after the boost and that cellular responses will also be similar one year later.

FUNDED PUBLICATIONS

  • Protective efficacy of standard Edmonston-Zagreb measles vaccination in infants aged 4.5 months: interim analysis of a randomised clinical trial.
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    20 TRIPLES      17 PREDICATES      21 URIs      10 LITERALS

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    1 grants:9a2aa5331aaddfb02294466c278fd5f9 sg:abstract Millions of children are given a booster dose of measles vaccine in mass immunisation campaigns throughout the world. It is not know if the rapidity of responses, which is likely to relate to protection against measles, varies according to the number of doses of measles vaccine the children have previously been given. We will compare these responses in children who have been part of previous trial of one or two doses of measles vaccine in Guinea Bissau. Technical Summary Little is known of short term antibody responses following a booster dose of measles vaccine in immunized children. We will compare the magnitude of these responses in three year old children who have received one or two doses of Edmonston-Zagreb vaccine in infancy as part of a previous trial in Bissau. Before and two weeks after a booster dose of E-Z vaccine haemagglutinin inhibiting (HAI) antibodies will be compared in the blood of the two groups of children. Long term antibody and cytokine responses to measles antigen will be measured one year after the boost. We predict that antibody concentrations will be similar in the two groups two weeks after the boost and that cellular responses will also be similar one year later.
    2 sg:endYear 2008
    3 sg:fundingAmount 9078.0
    4 sg:fundingCurrency GBP
    5 sg:hasContribution contributions:ce8dd3af3e4d3d04ab228d5ad3f95bb3
    6 sg:hasFieldOfResearchCode anzsrc-for:11
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    9 sg:hasFundedPublication articles:3177b345ea873afae0bebc8e348b6ed0
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    11 sg:hasRecipientOrganization grid-institutes:grid.415063.5
    12 sg:language English
    13 sg:license http://scigraph.springernature.com/explorer/license/
    14 Contains UK public sector information licensed under the Open Government Licence v2.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/2/).
    15 sg:scigraphId 9a2aa5331aaddfb02294466c278fd5f9
    16 sg:startYear 2007
    17 sg:title Two Dose E-Z Measles Vaccine Trial: Boosting Of Immune Responses In Bissau
    18 sg:webpage http://gtr.rcuk.ac.uk/project/DEFD1AA4-37CC-4186-8D3D-16AB1104B9A7
    19 rdf:type sg:Grant
    20 rdfs:label Grant: Two Dose E-Z Measles Vaccine Trial: Boosting Of Immune Responses In Bissau
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