YEARS

2006-2008

AUTHORS

Emily J Rogalski

TITLE

Memory in Primary Progressive Aphasia

ABSTRACT

DESCRIPTION (provided by applicant): This application proposes to study individuals with Primary Progressive Aphasia (PPA), a unique neurodegenerative disease that primarily affects the language network, to identify limitations in memory performance due to aphasia by manipulating standard implicit and explicit memory paradigms. More specifically, the studies will 1) measure interference caused by semantic relatedness, 2) compare verbal and nonverbal memory performance, and 3) vary stimulus presentation order (word-to-picture or picture-to- word) priming to determine vulnerabilities in PPA patient's memory performance. Results from the studies will provide behavioral information about the influence of aphasia on memory in a model where the lesions are not as arbitrary as they are in stroke related aphasia. Currently, evidence for preserved memory in PPA comes mainly from caregivers' observations of behavior in daily life, since it is difficult to assess memory clinically due to the language dependence of most neuropsychological tests. Thus, this proposal may have translational value clinically, since it may identify differences in the aphasic patients' memory that would result in a more comprehensive clinical characterization and, ultimately, better care.

FUNDED PUBLICATIONS

  • Primary progressive aphasia: relationship between gender and severity of language impairment.
  • Covert processing of words and pictures in nonsemantic variants of primary progressive aphasia.
  • Thinking Outside the Stroke: Treating Primary Progressive Aphasia (PPA).
  • False recognition of incidentally learned pictures and words in primary progressive aphasia.
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    21 TRIPLES      17 PREDICATES      22 URIs      9 LITERALS

    Subject Predicate Object
    1 grants:99e6b6b5b87ffe5de5138b5fd1f473f8 sg:abstract DESCRIPTION (provided by applicant): This application proposes to study individuals with Primary Progressive Aphasia (PPA), a unique neurodegenerative disease that primarily affects the language network, to identify limitations in memory performance due to aphasia by manipulating standard implicit and explicit memory paradigms. More specifically, the studies will 1) measure interference caused by semantic relatedness, 2) compare verbal and nonverbal memory performance, and 3) vary stimulus presentation order (word-to-picture or picture-to- word) priming to determine vulnerabilities in PPA patient's memory performance. Results from the studies will provide behavioral information about the influence of aphasia on memory in a model where the lesions are not as arbitrary as they are in stroke related aphasia. Currently, evidence for preserved memory in PPA comes mainly from caregivers' observations of behavior in daily life, since it is difficult to assess memory clinically due to the language dependence of most neuropsychological tests. Thus, this proposal may have translational value clinically, since it may identify differences in the aphasic patients' memory that would result in a more comprehensive clinical characterization and, ultimately, better care.
    2 sg:endYear 2008
    3 sg:fundingAmount 26798.0
    4 sg:fundingCurrency USD
    5 sg:hasContribution contributions:f53a90f4132d599b62691f79ac654916
    6 sg:hasFieldOfResearchCode anzsrc-for:17
    7 anzsrc-for:1701
    8 sg:hasFundedPublication articles:466725ae50393a315e98e1886b19e895
    9 articles:57138c5f692f41e834e6045bfab4c955
    10 articles:75762abed2f3a91fa412ad155da5ad53
    11 articles:8bee21bb749d5fd2f6a60376f16ce1df
    12 sg:hasFundingOrganization grid-institutes:grid.416870.c
    13 sg:hasRecipientOrganization grid-institutes:grid.16753.36
    14 sg:language English
    15 sg:license http://scigraph.springernature.com/explorer/license/
    16 sg:scigraphId 99e6b6b5b87ffe5de5138b5fd1f473f8
    17 sg:startYear 2006
    18 sg:title Memory in Primary Progressive Aphasia
    19 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=7113418
    20 rdf:type sg:Grant
    21 rdfs:label Grant: Memory in Primary Progressive Aphasia
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