YEARS

2010-2016

AUTHORS

Daniel Mirman

TITLE

Dynamics of Spoken Word Comprehension in Aphasia

ABSTRACT

Project Summary/Abstract Aphasia is a stroke-related disability of language processing that affects about one million people in the United States. Human activity is so dependent on spoken communication that impairments of spoken language processing, such as aphasia, can be devastating. In addition to functional impairments such as inability to work, language impairments can also cause social isolation and its consequent negative outcomes on mental and physical health. Because language processing calls on many different cognitive faculties, aphasia may have many different underlying causes and each aphasic individual may have a subtly different impairment. Designing effective rehabilitation strategies depends on our understanding of the nature of the impairment, thus, the focus of this proposal is on using behavioral experiments and computational modeling methods to develop a formal theory of aphasic spoken word comprehension. The proposed experiments will investigate phonological, semantic, and cognitive control aspects of word processing in a large and diverse set of aphasic individuals and unimpaired control participants using behavioral and eye tracking measures. These measures will provide new insights into the dynamics of word processing in aphasia. Computational modeling will be used to develop and test formal accounts of word processing deficits in aphasia. With a better understanding of the underlying causes of aphasic language impairments and a formal model of aphasia, more effective rehabilitation strategies can be developed.

FUNDED PUBLICATIONS

  • Competition and cooperation among similar representations: toward a unified account of facilitative and inhibitory effects of lexical neighbors.
  • Damage to temporo-parietal cortex decreases incidental activation of thematic relations during spoken word comprehension.
  • Neural organization of spoken language revealed by lesion-symptom mapping.
  • Incidental and context-responsive activation of structure- and function-based action features during object identification.
  • What we talk about when we talk about access deficits.
  • Interaction between phonological and semantic representations: time matters.
  • Effects of phonological and semantic deficits on facilitative and inhibitory consequences of item repetition in spoken word comprehension.
  • Neural organization of spoken language revealed by lesion–symptom mapping
  • Temporal dynamics of activation of thematic and functional knowledge during conceptual processing of manipulable artifacts.
  • Converging evidence from fMRI and aphasia that the left temporoparietal cortex has an essential role in representing abstract semantic knowledge.
  • The ins and outs of meaning: Behavioral and neuroanatomical dissociation of semantically-driven word retrieval and multimodal semantic recognition in aphasia.
  • Abnormal dynamics of activation of object use information in apraxia: evidence from eyetracking.
  • The neural basis of inhibitory effects of semantic and phonological neighbors in spoken word production.
  • Individual differences in the strength of taxonomic versus thematic relations.
  • Effect of repetition proportion on language-driven anticipatory eye movements.
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    35 TRIPLES      17 PREDICATES      36 URIs      9 LITERALS

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    3 sg:fundingAmount 1774447.0
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    32 sg:title Dynamics of Spoken Word Comprehension in Aphasia
    33 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=9172682
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