YEARS

2009-2015

AUTHORS

Christopher Rorden, Julius Fridriksson

TITLE

A Unified Neuroanatomical Model of Speech Production and Perception: Implications

ABSTRACT

DESCRIPTION (provided by applicant): Apraxia of speech (AOS) and conduction aphasia are commonly caused by left hemisphere stroke and often severely affect speech production. Although the clinical profile involved in these disorders is different, the most effective methods for managing them are unclear and many patients with AOS or conduction aphasia show limited recovery despite intensive treatment. We suggest that the underlying impairment in both AOS and conduction aphasia is poorly understood and propose a new framework for characterizing both disorders. Building on our previous research as well as the latest models of speech perception and production, this project will examine the neural bases of AOS and conduction aphasia. The result should be increased understanding of normal and disordered speech/language processing as well as offer new insights into rehabilitation of these two poorly understood disorders. Although the critical lesion locations associated with AOS and conduction aphasia have been controversial, recent studies suggest that damage to Broca's area and the left posterior inferior parietal lobe cause AOS and conduction aphasia, respectively. Along with others, our research has identified Broca's area as playing a role in not only the production of speech but also in the visual perception of others' speech motor movements. Similarly, recent studies (including our own) suggest that the left posterior inferior parietal lobe plays a critical role in speech processing as an interface between auditory speech and motor speech output. These findings suggest that individuals with AOS and conduction aphasia have an impaired speech perception component that may negatively affect recovery efforts aimed at improving speech production. Although this previous research has important theoretical and practical implications for understanding the neural basis of human communication as well as the nature of AOS and conduction aphasia, further study of this issue is imperative. This project will involve testing of a large group of stroke patients with left hemisphere damage as well as transcranial magnetic stimulation (TMS) to examine the effect of permanent (brain damage in stroke patients) and transient (TMS in normal participants) cortical interruption on speech processing. The long-term goals of this research are to better understand the neural bases of AOS and conduction aphasia. Treatments aimed at improving speech production in patients with AOS or conduction aphasia have traditionally proceeded with the assumption that speech perception is intact in both disorders. Therefore, it is crucial to understand the relationship between impaired speech production and perception in AOS and conduction aphasia. As a result, future treatments of thes frustrating and recovery resistant disorders can be greatly improved.

FUNDED PUBLICATIONS

  • Age-specific CT and MRI templates for spatial normalization.
  • Cerebral perfusion in chronic stroke: implications for lesion-symptom mapping and functional MRI.
  • Feasibility of using high-definition transcranial direct current stimulation (HD-tDCS) to enhance treatment outcomes in persons with aphasia.
  • Success of Anomia Treatment in Aphasia Is Associated With Preserved Architecture of Global and Left Temporal Lobe Structural Networks.
  • Chronic Broca's Aphasia Is Caused by Damage to Broca's and Wernicke's Areas.
  • Neuroanatomical foundations of naming impairments across different neurologic conditions.
  • Transcranial direct current stimulation improves naming reaction time in fluent aphasia: a double-blind, sham-controlled study.
  • Perception drives production across sensory modalities: A network for sensorimotor integration of visual speech.
  • Assessing the clinical effect of residual cortical disconnection after ischemic strokes.
  • Damage to the anterior arcuate fasciculus predicts non-fluent speech production in aphasia.
  • Impaired speech repetition and left parietal lobe damage.
  • Using transcranial direct-current stimulation to treat stroke patients with aphasia.
  • Patterns of poststroke brain damage that predict speech production errors in apraxia of speech and aphasia dissociate.
  • Predicting aphasia type from brain damage measured with structural MRI.
  • StimSync: open-source hardware for behavioral and MRI experiments.
  • Re-establishing Broca's initial findings.
  • Individualized model predicts brain current flow during transcranial direct-current stimulation treatment in responsive stroke patient.
  • The superior precentral gyrus of the insula does not appear to be functionally specialized for articulation.
  • Speech entrainment enables patients with Broca's aphasia to produce fluent speech.
  • Measuring and inducing brain plasticity in chronic aphasia.
  • Activity in preserved left hemisphere regions predicts anomia severity in aphasia.
  • Concepts within reach: Action performance predicts action language processing in stroke.
  • Allocentric neglect strongly associated with egocentric neglect.
  • Speech entrainment compensates for Broca's area damage.
  • Left hemisphere plasticity and aphasia recovery.
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