YEARS

2004-2007

AUTHORS

Thomas J. Grabowski

TITLE

Time-Aware fMRI for Interactive Naming in Aphasia

ABSTRACT

DESCRIPTION (provided by applicant): Event-related fMRI is appealing for augmenting diagnosis, planning treatment, and monitoring course in clinical populations. However, fMRI must be able to accommodate variable performance success, failure to conform to task protocol, and reduced tolerance for the physical demands of an imaging session. We propose to exploit a "time aware" data acquisition and processing system to implement an interactive approach to fMRI, tailored to individual subject performance. The system allows real-time paradigm control featuring interaction of the subject with an examiner. The paradigm chosen for proof of concept is cue-facilitated word retrieval, in which aphasics perform naming to visual confrontation, and are given phonemic cues when they fail to name an item. The software architecture permits generation of statistical contrasts that take account of actual performance, in real time, and incremental monitoring of the statistical quality of the data. The goal is to generate standardized results for longitudinal studies of speech production in aphasia. We will evaluate the stability of these measures in chronic aphasics and in normal subjects. The results will provide a basis for assessing feasibility and power of future applications of fMRI in aphasia rehabilitation. The tools developed here will be made available to the research community.

FUNDED PUBLICATIONS

  • Adaptive pacing of visual stimulation for fMRI studies involving overt speech.
  • How to use: Click on a object to move its position. Double click to open its homepage. Right click to preview its contents.

    Download the RDF metadata as:   json-ld nt turtle xml License info


    18 TRIPLES      17 PREDICATES      19 URIs      9 LITERALS

    Subject Predicate Object
    1 grants:359aac00910e98ee3a3b9cf3d36d7ed3 sg:abstract DESCRIPTION (provided by applicant): Event-related fMRI is appealing for augmenting diagnosis, planning treatment, and monitoring course in clinical populations. However, fMRI must be able to accommodate variable performance success, failure to conform to task protocol, and reduced tolerance for the physical demands of an imaging session. We propose to exploit a "time aware" data acquisition and processing system to implement an interactive approach to fMRI, tailored to individual subject performance. The system allows real-time paradigm control featuring interaction of the subject with an examiner. The paradigm chosen for proof of concept is cue-facilitated word retrieval, in which aphasics perform naming to visual confrontation, and are given phonemic cues when they fail to name an item. The software architecture permits generation of statistical contrasts that take account of actual performance, in real time, and incremental monitoring of the statistical quality of the data. The goal is to generate standardized results for longitudinal studies of speech production in aphasia. We will evaluate the stability of these measures in chronic aphasics and in normal subjects. The results will provide a basis for assessing feasibility and power of future applications of fMRI in aphasia rehabilitation. The tools developed here will be made available to the research community.
    2 sg:endYear 2007
    3 sg:fundingAmount 295000.0
    4 sg:fundingCurrency USD
    5 sg:hasContribution contributions:43d7a41cc8011508fc0ff5824b1e8c79
    6 sg:hasFieldOfResearchCode anzsrc-for:17
    7 anzsrc-for:1701
    8 sg:hasFundedPublication articles:92c54a686db930e584acdb300d9d40a3
    9 sg:hasFundingOrganization grid-institutes:grid.280347.a
    10 sg:hasRecipientOrganization grid-institutes:grid.214572.7
    11 sg:language English
    12 sg:license http://scigraph.springernature.com/explorer/license/
    13 sg:scigraphId 359aac00910e98ee3a3b9cf3d36d7ed3
    14 sg:startYear 2004
    15 sg:title Time-Aware fMRI for Interactive Naming in Aphasia
    16 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=6887783
    17 rdf:type sg:Grant
    18 rdfs:label Grant: Time-Aware fMRI for Interactive Naming in Aphasia
    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular JSON format for linked data.

    curl -H 'Accept: application/ld+json' 'http://scigraph.springernature.com/things/grants/359aac00910e98ee3a3b9cf3d36d7ed3'

    N-Triples is a line-based linked data format ideal for batch operations .

    curl -H 'Accept: application/n-triples' 'http://scigraph.springernature.com/things/grants/359aac00910e98ee3a3b9cf3d36d7ed3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'http://scigraph.springernature.com/things/grants/359aac00910e98ee3a3b9cf3d36d7ed3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'http://scigraph.springernature.com/things/grants/359aac00910e98ee3a3b9cf3d36d7ed3'






    Preview window. Press ESC to close (or click here)


    ...