YEARS

1996-2003

AUTHORS

Delaina Walker-Batson

TITLE

PHARMACOLOGIC MODULATION IN THE TREATMENT OF APHASIA

ABSTRACT

DESCRIPTION: (Adapted From The Investigator s Abstract): The long-term goal of this research is to determine the efficacy of pharmacologic modulation in the treatment of aphasia subsequent to stroke with oral doses of d-amphetamine (AMP). This is a double-blind parallel study of the use of AMP to modify or promote recovery from aphasia. This work is a critical extension of a large body of animal studies which have provided strong evidence related to the role of norepinephrine (NE) in central nervous system recover processes. The specific aims of the project are: (1) to determine the efficacy of using pharmacologic modulation in the treatment of aphasia following an occlusive left hemisphere stroke and (2) to provide evaluation of the drug treatment within a double-blind parallel design through a six- week drug treatment period and long-term follow-up. Efficacy will be evaluated by Overall Percentile Scores on the Porch Index of Communicative Abilities. Thirty-two patients will be studied over the three-year course of this study and receive either AMP or placebo over ten alternating treatment sessions and then be followed over 12 months. Additionally, patients will be described neurologically (NIH Stroke Scale) and radiologically (MRI) to further enhance understanding of possible relationships between response/nonresponse to drug therapy. The American Speech and Hearing Association Functional Assessment of Communication Skills (ASHA FACS) will be administered to assess functional communication. The debilitating effects of stroke and aphasia are long-term and represent a major adult health problem. To date, there has been no systematic pharmacologic therapy employed in rehabilitation of aphasia. If a relatively simple pharmacologic treatment with an established drug would be found to accelerate rate and/or extent of recovery from aphasia, it would have wide-reaching application.

FUNDED PUBLICATIONS

  • A double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia.
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    19 TRIPLES      17 PREDICATES      20 URIs      9 LITERALS

    Subject Predicate Object
    1 grants:2a0c9021af36dc7baf997cceed50acc9 sg:abstract DESCRIPTION: (Adapted From The Investigator s Abstract): The long-term goal of this research is to determine the efficacy of pharmacologic modulation in the treatment of aphasia subsequent to stroke with oral doses of d-amphetamine (AMP). This is a double-blind parallel study of the use of AMP to modify or promote recovery from aphasia. This work is a critical extension of a large body of animal studies which have provided strong evidence related to the role of norepinephrine (NE) in central nervous system recover processes. The specific aims of the project are: (1) to determine the efficacy of using pharmacologic modulation in the treatment of aphasia following an occlusive left hemisphere stroke and (2) to provide evaluation of the drug treatment within a double-blind parallel design through a six- week drug treatment period and long-term follow-up. Efficacy will be evaluated by Overall Percentile Scores on the Porch Index of Communicative Abilities. Thirty-two patients will be studied over the three-year course of this study and receive either AMP or placebo over ten alternating treatment sessions and then be followed over 12 months. Additionally, patients will be described neurologically (NIH Stroke Scale) and radiologically (MRI) to further enhance understanding of possible relationships between response/nonresponse to drug therapy. The American Speech and Hearing Association Functional Assessment of Communication Skills (ASHA FACS) will be administered to assess functional communication. The debilitating effects of stroke and aphasia are long-term and represent a major adult health problem. To date, there has been no systematic pharmacologic therapy employed in rehabilitation of aphasia. If a relatively simple pharmacologic treatment with an established drug would be found to accelerate rate and/or extent of recovery from aphasia, it would have wide-reaching application.
    2 sg:endYear 2003
    3 sg:fundingAmount 50000.0
    4 sg:fundingCurrency USD
    5 sg:hasContribution contributions:c2eea03cdaee5a400c25a7ca42f7c40c
    6 sg:hasFieldOfResearchCode anzsrc-for:11
    7 anzsrc-for:1103
    8 anzsrc-for:1109
    9 sg:hasFundedPublication articles:7ba95d7cf7ab32830c3aec8bbcf1bedf
    10 sg:hasFundingOrganization grid-institutes:grid.214431.1
    11 sg:hasRecipientOrganization grid-institutes:grid.264797.9
    12 sg:language English
    13 sg:license http://scigraph.springernature.com/explorer/license/
    14 sg:scigraphId 2a0c9021af36dc7baf997cceed50acc9
    15 sg:startYear 1996
    16 sg:title PHARMACOLOGIC MODULATION IN THE TREATMENT OF APHASIA
    17 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=6447895
    18 rdf:type sg:Grant
    19 rdfs:label Grant: PHARMACOLOGIC MODULATION IN THE TREATMENT OF APHASIA
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