YEARS

2004-2010

AUTHORS

Joseph T Sakai

TITLE

Asian Teens, substance dependence and conduct disorder

ABSTRACT

DESCRIPTION (provided by applicant): This application proposes five years of support to investigate the relationship between substance dependence, conduct disorder and certain genetic polymorphisms among Asian American adolescents. There is little research characterizing conduct disordered Asian American adolescents. General population estimates and the applicant's preliminary data suggest conduct disordered Asian American adolescents are a high-risk population for comorbid substance use disorders. Asians also have high prevalence of alleles that are known to affect alcohol and nicotine metabolism. Therefore, conduct disordered Asian American adolescents likely represent a genetically informative population regarding adolescent substance use disorders. The applicant proposes to collect a sample of Asian American adolescents with conduct disorder (n=100), Asian adolescent controls (n=200), and first-degree relatives of conduct disordered probands (n=162). The aims include 1) examining the relationship between conduct disorder and substance use disorders among Asian American adolescents, 2) testing whether substance dependence and conduct disorder are familial in Asian American families, and 3) testing whether ALDH and CYP2A6 genotypes are associated with alcohol and nicotine dependence. The proposed training includes 1) completion of formal coursework and workshops dealing with twin studies, genetic association and linkage studies, 2) mentored analyses of data already collected (DA11015), focusing on within and between family genetic association studies of adolescent substance use disorders, 3) mentored analyses of national data bases examining risk factors for substance dependence among Asian Americans, and 4) attendance at national meetings.

FUNDED PUBLICATIONS

  • Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives.
  • Progression from marijuana use to daily smoking and nicotine dependence in a national sample of U.S. adolescents.
  • Toward DSM-V: an item response theory analysis of the diagnostic process for DSM-IV alcohol abuse and dependence in adolescents.
  • Substance use and dependence among Native Hawaiians, Other Pacific Islanders, and Asian ethnic groups in the United States: contrasting multiple-race and single-race prevalence rates from a national survey.
  • Gender similarities and differences in antisocial behavioral syndromes among injection drug users.
  • Adolescent inhalant use among male patients in treatment for substance and behavior problems: two-year outcome.
  • Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder.
  • Medical student attitudes to risk taking and self-perceived influence on medical practice.
  • Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems.
  • Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults.
  • Case-control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample.
  • Conduct disorder among Asians and Native Hawaiian/Pacific Islanders in the USA.
  • An item response theory analysis of DSM-IV conduct disorder.
  • Using trajectory analyses to refine phenotype for genetic association: conduct problems and the serotonin transporter (5HTTLPR).
  • Case-control and within-family tests for an association between conduct disorder and 5HTTLPR.
  • The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults.
  • Asians in the United States: substance dependence and use of substance-dependence treatment.
  • Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents.
  • DSM-IV conduct disorder criteria as predictors of antisocial personality disorder.
  • Validity of transdermal alcohol monitoring: fixed and self-regulated dosing.
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    37 TRIPLES      17 PREDICATES      38 URIs      9 LITERALS

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    34 sg:title Asian Teens, substance dependence and conduct disorder
    35 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=7491612
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