YEARS

-

AUTHORS

Phillip Gorden

TITLE

Studies of clinical endocrine tumors

ABSTRACT

Specific endocrine syndromes are produced in response to benign and malignant tumors of endocrine tissue. We have been part of a collaborative group in the Clinical Center, NCI, and NINDS. We study patients with acromegaly in collaboration with Dr. Edward Oldfield of NINDS. These studies consist of careful phenotypic characterization of the patient followed by surgery to remove the adenoma. This is followed by histologic and molecular genetic characterization so that phenotypic-genotypic characterization can be made. The second group of studies is in collaboration with Dr. Steven Libutti in which a similar group of phenotypic-genotypic characterization is underway. In addition, Clinical Center Radiology is involved in collaboration to localize the pancreatic tumors for surgical localization. These tumors have also been used as a resource by other investigators in NIDDK, by other institutes and by NCI pathology.

FUNDED PUBLICATIONS

  • Hypoglycemia.
  • Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor.
  • Localization of insulinomas to regions of the pancreas by intraarterial calcium stimulation: the NIH experience.
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    18 TRIPLES      15 PREDICATES      18 URIs      7 LITERALS

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    1 grants:0115217ccda021889fd7113cdbbbc2af sg:abstract Specific endocrine syndromes are produced in response to benign and malignant tumors of endocrine tissue. We have been part of a collaborative group in the Clinical Center, NCI, and NINDS. We study patients with acromegaly in collaboration with Dr. Edward Oldfield of NINDS. These studies consist of careful phenotypic characterization of the patient followed by surgery to remove the adenoma. This is followed by histologic and molecular genetic characterization so that phenotypic-genotypic characterization can be made. The second group of studies is in collaboration with Dr. Steven Libutti in which a similar group of phenotypic-genotypic characterization is underway. In addition, Clinical Center Radiology is involved in collaboration to localize the pancreatic tumors for surgical localization. These tumors have also been used as a resource by other investigators in NIDDK, by other institutes and by NCI pathology.
    2 sg:fundingAmount 373372.0
    3 sg:fundingCurrency USD
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    7 sg:hasFundedPublication articles:4fc00d8fc52855f87463c1b5f1647119
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    9 articles:cfe1412edd3eff0a3f4f06d42b84c5f3
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    12 sg:language English
    13 sg:license http://scigraph.springernature.com/explorer/license/
    14 sg:scigraphId 0115217ccda021889fd7113cdbbbc2af
    15 sg:title Studies of clinical endocrine tumors
    16 sg:webpage http://projectreporter.nih.gov/project_info_description.cfm?aid=7734161
    17 rdf:type sg:Grant
    18 rdfs:label Grant: Studies of clinical endocrine tumors
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