PUBLICATION DATE

2013-09

TITLE

Primary progressive aphasia and apraxia of speech.

ISSUE

4

VOLUME

33

ISSN (print)

N/A

ISSN (electronic)

N/A

ABSTRACT

Primary progressive aphasia is a neurodegenerative syndrome characterized by progressive language dysfunction. The majority of primary progressive aphasia cases can be classified into three subtypes: nonfluent/agrammatic, semantic, and logopenic variants. Each variant presents with unique clinical features, and is associated with distinctive underlying pathology and neuroimaging findings. Unlike primary progressive aphasia, apraxia of speech is a disorder that involves inaccurate production of sounds secondary to impaired planning or programming of speech movements. Primary progressive apraxia of speech is a neurodegenerative form of apraxia of speech, and it should be distinguished from primary progressive aphasia given its discrete clinicopathological presentation. Recently, there have been substantial advances in our understanding of these speech and language disorders. The clinical, neuroimaging, and histopathological features of primary progressive aphasia and apraxia of speech are reviewed in this article. The distinctions among these disorders for accurate diagnosis are increasingly important from a prognostic and therapeutic standpoint.

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JOURNAL BRAND

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    14 TRIPLES      14 PREDICATES      15 URIs      10 LITERALS

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    1 articles:ef4c3c882a37c06779df420fb786a3ee sg:abstract Primary progressive aphasia is a neurodegenerative syndrome characterized by progressive language dysfunction. The majority of primary progressive aphasia cases can be classified into three subtypes: nonfluent/agrammatic, semantic, and logopenic variants. Each variant presents with unique clinical features, and is associated with distinctive underlying pathology and neuroimaging findings. Unlike primary progressive aphasia, apraxia of speech is a disorder that involves inaccurate production of sounds secondary to impaired planning or programming of speech movements. Primary progressive apraxia of speech is a neurodegenerative form of apraxia of speech, and it should be distinguished from primary progressive aphasia given its discrete clinicopathological presentation. Recently, there have been substantial advances in our understanding of these speech and language disorders. The clinical, neuroimaging, and histopathological features of primary progressive aphasia and apraxia of speech are reviewed in this article. The distinctions among these disorders for accurate diagnosis are increasingly important from a prognostic and therapeutic standpoint.
    2 sg:doi 10.1055/s-0033-1359317
    3 sg:doiLink http://dx.doi.org/10.1055/s-0033-1359317
    4 sg:isFundedPublicationOf grants:30c13dd7b841303d501f44fcbffbad34
    5 sg:issue 4
    6 sg:language English
    7 sg:license http://scigraph.springernature.com/explorer/license/
    8 sg:publicationYear 2013
    9 sg:publicationYearMonth 2013-09
    10 sg:scigraphId ef4c3c882a37c06779df420fb786a3ee
    11 sg:title Primary progressive aphasia and apraxia of speech.
    12 sg:volume 33
    13 rdf:type sg:Article
    14 rdfs:label Article: Primary progressive aphasia and apraxia of speech.
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