PUBLICATION DATE

1984-12

TITLE

Malignant melanoma in World War II veterans.

ISSUE

10

VOLUME

23

ISSN (print)

N/A

ISSN (electronic)

N/A

ABSTRACT

In a consecutive series of 1,067 patients entered into the data base of the Melanoma Cooperative Group at New York University School of Medicine between 1972 and 1980, 120 men were of draft age (18-31 years) during World War II (1941-1945). Questionnaires were sent to these 120 individuals; 89 responded. Simultaneously, a control (nonmelanoma) population of 65 men of similar age was queried. Each subject in both groups was asked whether he had served in the armed forces during World War II and, if so, what were his theaters of operation. Based on the response, 83% (74 of 89) of the melanoma group compared with 76% (49 of 65) of the control group had served in the armed forces during World War II; however, a significantly (p = 0.0002) greater percent of the melanoma patients (34%) served in the tropics than did the control subjects (6%). Further, overrepresented in the melanoma group that served in the tropics (compared with the melanoma group who served in the armed forces in nontropical theaters) were malignant melanomas that had their origin in nevocytic nevi. The findings suggest that Caucasian individuals heavily exposed to sunlight in the tropics for several years during early life may be at higher risk to the subsequent development of cutaneous malignant melanoma. In some individuals this may be a two-step phenomenon, in which the first step is the solar induction of nevocytic nevi and the second is malignant transformation within them.

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    14 TRIPLES      14 PREDICATES      15 URIs      10 LITERALS

    Subject Predicate Object
    1 articles:dc3f7507b0fc12768a477d43d66c2ec4 sg:abstract In a consecutive series of 1,067 patients entered into the data base of the Melanoma Cooperative Group at New York University School of Medicine between 1972 and 1980, 120 men were of draft age (18-31 years) during World War II (1941-1945). Questionnaires were sent to these 120 individuals; 89 responded. Simultaneously, a control (nonmelanoma) population of 65 men of similar age was queried. Each subject in both groups was asked whether he had served in the armed forces during World War II and, if so, what were his theaters of operation. Based on the response, 83% (74 of 89) of the melanoma group compared with 76% (49 of 65) of the control group had served in the armed forces during World War II; however, a significantly (p = 0.0002) greater percent of the melanoma patients (34%) served in the tropics than did the control subjects (6%). Further, overrepresented in the melanoma group that served in the tropics (compared with the melanoma group who served in the armed forces in nontropical theaters) were malignant melanomas that had their origin in nevocytic nevi. The findings suggest that Caucasian individuals heavily exposed to sunlight in the tropics for several years during early life may be at higher risk to the subsequent development of cutaneous malignant melanoma. In some individuals this may be a two-step phenomenon, in which the first step is the solar induction of nevocytic nevi and the second is malignant transformation within them.
    2 sg:doi 10.1111/j.1365-4362.1984.tb01228.x
    3 sg:doiLink http://dx.doi.org/10.1111/j.1365-4362.1984.tb01228.x
    4 sg:isFundedPublicationOf grants:18f56d0cf354441802b814448291f556
    5 sg:issue 10
    6 sg:language English
    7 sg:license http://scigraph.springernature.com/explorer/license/
    8 sg:publicationYear 1984
    9 sg:publicationYearMonth 1984-12
    10 sg:scigraphId dc3f7507b0fc12768a477d43d66c2ec4
    11 sg:title Malignant melanoma in World War II veterans.
    12 sg:volume 23
    13 rdf:type sg:Article
    14 rdfs:label Article: Malignant melanoma in World War II veterans.
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