PUBLICATION DATE

2013-11

TITLE

Identification of an atypical variant of logopenic progressive aphasia.

ISSUE

2

VOLUME

127

ISSN (print)

N/A

ISSN (electronic)

N/A

ABSTRACT

The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease duration. Cluster analysis identified three variants of lvPPA: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long disease duration (severe typical lvPPA). All three variants showed temporoparietal atrophy, with the mild atypical group showing the least atrophy despite the longest disease duration. The mild atypical group also showed mild neuropsychological impairment. The subjects with mild aphasia and neuropsychological impairment despite long disease duration may represent a slowly progressive variant of lvPPA.

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JOURNAL BRAND

N/A (note: articles not published by Springer Nature have limited metadata)


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    14 TRIPLES      14 PREDICATES      15 URIs      10 LITERALS

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    1 articles:ccaf8d832f1f9a541193785726f7aee0 sg:abstract The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease duration. Cluster analysis identified three variants of lvPPA: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long disease duration (severe typical lvPPA). All three variants showed temporoparietal atrophy, with the mild atypical group showing the least atrophy despite the longest disease duration. The mild atypical group also showed mild neuropsychological impairment. The subjects with mild aphasia and neuropsychological impairment despite long disease duration may represent a slowly progressive variant of lvPPA.
    2 sg:doi 10.1016/j.bandl.2013.02.007
    3 sg:doiLink http://dx.doi.org/10.1016/j.bandl.2013.02.007
    4 sg:isFundedPublicationOf grants:30c13dd7b841303d501f44fcbffbad34
    5 sg:issue 2
    6 sg:language English
    7 sg:license http://scigraph.springernature.com/explorer/license/
    8 sg:publicationYear 2013
    9 sg:publicationYearMonth 2013-11
    10 sg:scigraphId ccaf8d832f1f9a541193785726f7aee0
    11 sg:title Identification of an atypical variant of logopenic progressive aphasia.
    12 sg:volume 127
    13 rdf:type sg:Article
    14 rdfs:label Article: Identification of an atypical variant of logopenic progressive aphasia.
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