PUBLICATION DATE

2002

TITLE

Progressive aphasia with Lewy bodies.

ISSUE

2

VOLUME

14

ISSN (print)

N/A

ISSN (electronic)

N/A

ABSTRACT

Dementia with Lewy bodies (DLB) may include both Alzheimer and Lewy body pathology, but has never been reported to cause primary progressive aphasia. We report a 69-year-old woman who died 11 years after presenting with the syndrome of progressive aphasia. Six years after aphasia onset she developed visual hallucinations, and subsequently parkinsonism. Autopsy examination revealed Alzheimer's disease (AD), cortical Lewy bodies, and depigmentation and Lewy bodies in the substantia nigra and locus ceruleus. The aphasia most likely reflected the initial onset of AD, and the psychosis and parkinsonism most likely reflected the subsequent onset of Lewy body pathology. This first reported case of progressive aphasia occurring within the context of AD and Lewy body pathology uniquely illustrates the clinical and pathological nosological relationships between these two disease processes, and demonstrates a limitation of the general term, 'DLB'.

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JOURNAL BRAND

N/A (note: articles not published by Springer Nature have limited metadata)


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  • Arizona Alzheimer's Disease Core Center
  • Pet, Apoe &The Preclinical Course Of Alzheimer Disease
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    14 TRIPLES      13 PREDICATES      15 URIs      9 LITERALS

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    1 articles:c4b57a7f2d92999809f16aecd884f066 sg:abstract Dementia with Lewy bodies (DLB) may include both Alzheimer and Lewy body pathology, but has never been reported to cause primary progressive aphasia. We report a 69-year-old woman who died 11 years after presenting with the syndrome of progressive aphasia. Six years after aphasia onset she developed visual hallucinations, and subsequently parkinsonism. Autopsy examination revealed Alzheimer's disease (AD), cortical Lewy bodies, and depigmentation and Lewy bodies in the substantia nigra and locus ceruleus. The aphasia most likely reflected the initial onset of AD, and the psychosis and parkinsonism most likely reflected the subsequent onset of Lewy body pathology. This first reported case of progressive aphasia occurring within the context of AD and Lewy body pathology uniquely illustrates the clinical and pathological nosological relationships between these two disease processes, and demonstrates a limitation of the general term, 'DLB'.
    2 sg:doi 10.1159/000064925
    3 sg:doiLink http://dx.doi.org/10.1159/000064925
    4 sg:isFundedPublicationOf grants:ef9ab64d50f9fd67c5da2d438e7d4be1
    5 grants:f0ca2fef3f5a79f26a0de83e7028534b
    6 sg:issue 2
    7 sg:language English
    8 sg:license http://scigraph.springernature.com/explorer/license/
    9 sg:publicationYear 2002
    10 sg:scigraphId c4b57a7f2d92999809f16aecd884f066
    11 sg:title Progressive aphasia with Lewy bodies.
    12 sg:volume 14
    13 rdf:type sg:Article
    14 rdfs:label Article: Progressive aphasia with Lewy bodies.
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