PUBLICATION DATE

2004

TITLE

Test-retest reliability of fMRI during nonverbal semantic decisions in moderate-severe nonfluent aphasia patients.

ISSUE

3-4

VOLUME

15

ISSN (print)

N/A

ISSN (electronic)

N/A

ABSTRACT

Cortical reorganization in poststroke aphasia is not well understood. Few studies have investigated neural mechanisms underlying language recovery in severe aphasia patients, who are typically viewed as having a poor prognosis for language recovery. Although test-retest reliability is routinely demonstrated during collection of language data in single-subject aphasia research, this is rarely examined in fMRI studies investigating the underlying neural mechanisms in aphasia recovery. The purpose of this study was to acquire fMRI test-retest data examining semantic decisions both within and between two aphasia patients. Functional MRI was utilized to image individuals with chronic, moderate-severe nonfluent aphasia during nonverbal, yes/no button-box semantic judgments of iconic sentences presented in the Computer-assisted Visual Communication (C-ViC) program. We investigated the critical issue of intra-subject reliability by exploring similarities and differences in regions of activation during participants' performance of identical tasks twice on the same day. Each participant demonstrated high intra-subject reliability, with response decrements typical of task familiarity. Differences between participants included greater left hemisphere perilesional activation in the individual with better response to C-ViC training. This study provides fMRI reliability in chronic nonfluent aphasia, and adds to evidence supporting differences in individual cortical reorganization in aphasia recovery.

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JOURNAL BRAND

N/A (note: articles not published by Springer Nature have limited metadata)


FROM GRANT

  • Transcranial Magnetic Stimulation To Improve Speech
  • Boston University Aphasia Research Core Center
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    14 TRIPLES      13 PREDICATES      15 URIs      9 LITERALS

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    1 articles:c439c13c60b5f0d5f95abd519feb71d1 sg:abstract Cortical reorganization in poststroke aphasia is not well understood. Few studies have investigated neural mechanisms underlying language recovery in severe aphasia patients, who are typically viewed as having a poor prognosis for language recovery. Although test-retest reliability is routinely demonstrated during collection of language data in single-subject aphasia research, this is rarely examined in fMRI studies investigating the underlying neural mechanisms in aphasia recovery. The purpose of this study was to acquire fMRI test-retest data examining semantic decisions both within and between two aphasia patients. Functional MRI was utilized to image individuals with chronic, moderate-severe nonfluent aphasia during nonverbal, yes/no button-box semantic judgments of iconic sentences presented in the Computer-assisted Visual Communication (C-ViC) program. We investigated the critical issue of intra-subject reliability by exploring similarities and differences in regions of activation during participants' performance of identical tasks twice on the same day. Each participant demonstrated high intra-subject reliability, with response decrements typical of task familiarity. Differences between participants included greater left hemisphere perilesional activation in the individual with better response to C-ViC training. This study provides fMRI reliability in chronic nonfluent aphasia, and adds to evidence supporting differences in individual cortical reorganization in aphasia recovery.
    2 sg:doi 10.1155/2004/974094
    3 sg:doiLink http://dx.doi.org/10.1155/2004/974094
    4 sg:isFundedPublicationOf grants:9c8e80cee74f4ecf90c1fbb7d7b3529a
    5 grants:f8d9ce37351c6b69b1eed5c55e78545f
    6 sg:issue 3-4
    7 sg:language English
    8 sg:license http://scigraph.springernature.com/explorer/license/
    9 sg:publicationYear 2004
    10 sg:scigraphId c439c13c60b5f0d5f95abd519feb71d1
    11 sg:title Test-retest reliability of fMRI during nonverbal semantic decisions in moderate-severe nonfluent aphasia patients.
    12 sg:volume 15
    13 rdf:type sg:Article
    14 rdfs:label Article: Test-retest reliability of fMRI during nonverbal semantic decisions in moderate-severe nonfluent aphasia patients.
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