PUBLICATION DATE

2013-06

TITLE

Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study.

ISSUE

3

VOLUME

125

ISSN (print)

N/A

ISSN (electronic)

N/A

ABSTRACT

Progressive apraxia of speech (AOS) can result from neurodegenerative disease and can occur in isolation or in the presence of agrammatic aphasia. We aimed to determine the neuroanatomical and metabolic correlates of progressive AOS and aphasia. Thirty-six prospectively recruited subjects with progressive AOS or agrammatic aphasia, or both, underwent the Western Aphasia Battery (WAB) and Token Test to assess aphasia, an AOS rating scale (ASRS), 3T MRI and 18-F fluorodeoxyglucose (FDG) PET. Correlations between clinical measures and imaging were assessed. The only region that correlated to ASRS was left superior premotor volume. In contrast, WAB and Token Test correlated with hypometabolism and volume of a network of left hemisphere regions, including pars triangularis, pars opercularis, pars orbitalis, middle frontal gyrus, superior temporal gyrus, precentral gyrus and inferior parietal lobe. Progressive agrammatic aphasia and AOS have non-overlapping regional correlations, suggesting that these are dissociable clinical features that have different neuroanatomical underpinnings.

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JOURNAL BRAND

N/A (note: articles not published by Springer Nature have limited metadata)


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    14 TRIPLES      14 PREDICATES      15 URIs      10 LITERALS

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    1 articles:456833b4c5424e35b835a0dc3b75e0f7 sg:abstract Progressive apraxia of speech (AOS) can result from neurodegenerative disease and can occur in isolation or in the presence of agrammatic aphasia. We aimed to determine the neuroanatomical and metabolic correlates of progressive AOS and aphasia. Thirty-six prospectively recruited subjects with progressive AOS or agrammatic aphasia, or both, underwent the Western Aphasia Battery (WAB) and Token Test to assess aphasia, an AOS rating scale (ASRS), 3T MRI and 18-F fluorodeoxyglucose (FDG) PET. Correlations between clinical measures and imaging were assessed. The only region that correlated to ASRS was left superior premotor volume. In contrast, WAB and Token Test correlated with hypometabolism and volume of a network of left hemisphere regions, including pars triangularis, pars opercularis, pars orbitalis, middle frontal gyrus, superior temporal gyrus, precentral gyrus and inferior parietal lobe. Progressive agrammatic aphasia and AOS have non-overlapping regional correlations, suggesting that these are dissociable clinical features that have different neuroanatomical underpinnings.
    2 sg:doi 10.1016/j.bandl.2013.02.005
    3 sg:doiLink http://dx.doi.org/10.1016/j.bandl.2013.02.005
    4 sg:isFundedPublicationOf grants:30c13dd7b841303d501f44fcbffbad34
    5 sg:issue 3
    6 sg:language English
    7 sg:license http://scigraph.springernature.com/explorer/license/
    8 sg:publicationYear 2013
    9 sg:publicationYearMonth 2013-06
    10 sg:scigraphId 456833b4c5424e35b835a0dc3b75e0f7
    11 sg:title Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study.
    12 sg:volume 125
    13 rdf:type sg:Article
    14 rdfs:label Article: Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study.
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