PUBLICATION DATE

2000-04

AUTHORS

Sergei F. Krasnyanski, Dennis E. Buetow, Mark D. Osadjan, Schuyler S. Korban, Leslie L. Domier, Jagdeep S. Sandhu

TITLE

Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response

ISSUE

2

VOLUME

9

ISSN (print)

0962-8819

ISSN (electronic)

1573-9368

ABSTRACT

Respiratory syncytial virus (RSV) is one of the most important pathogens of infancy and early childhood. Here a fruit-based edible subunit vaccine against RSV was developed by expressing the RSV fusion (F) protein gene in transgenic tomato plants. The F-gene was expressed in ripening tomato fruit under the control of the fruit-specific E8 promoter. Oral immunization of mice with ripe transgenic tomato fruits led to the induction of both serum and mucosal RSV-F specific antibodies. The ratio of immunoglobulin subclasses produced in response to immunization suggested that a type 1 T-helper cell immune response was preferentially induced. Serum antibodies showed an increased titer when the immunized mice were exposed to inactivated RSV antigen.

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1 articles:3503a72466a47c03b94dddf8b6383b79 sg:abstract Abstract Respiratory syncytial virus (RSV) is one of the most important pathogens of infancy and early childhood. Here a fruit-based edible subunit vaccine against RSV was developed by expressing the RSV fusion (F) protein gene in transgenic tomato plants. The F-gene was expressed in ripening tomato fruit under the control of the fruit-specific E8 promoter. Oral immunization of mice with ripe transgenic tomato fruits led to the induction of both serum and mucosal RSV-F specific antibodies. The ratio of immunoglobulin subclasses produced in response to immunization suggested that a type 1 T-helper cell immune response was preferentially induced. Serum antibodies showed an increased titer when the immunized mice were exposed to inactivated RSV antigen.
2 sg:articleType OriginalPaper
3 sg:coverYear 2000
4 sg:coverYearMonth 2000-04
5 sg:ddsId Art6
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7 sg:doi 10.1023/A:1008979525909
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22 sg:issnElectronic 1573-9368
23 sg:issnPrint 0962-8819
24 sg:issue 2
25 sg:language English
26 sg:license http://scigraph.springernature.com/explorer/license/
27 sg:pageEnd 135
28 sg:pageStart 127
29 sg:publicationYear 2000
30 sg:publicationYearMonth 2000-04
31 sg:scigraphId 3503a72466a47c03b94dddf8b6383b79
32 sg:title Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response
33 sg:volume 9
34 sg:webpage https://link.springer.com/10.1023/A:1008979525909
35 rdf:type sg:Article
36 rdfs:label Article: Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response
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