PUBLICATION DATE

2015

TITLE

Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study.

ISSUE

N/A

VOLUME

145-146

ISSN (print)

N/A

ISSN (electronic)

N/A

ABSTRACT

Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials.

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JOURNAL BRAND

N/A (note: articles not published by Springer Nature have limited metadata)


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    12 TRIPLES      12 PREDICATES      13 URIs      8 LITERALS

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    1 articles:036a703917bea0843494050b450e6257 sg:abstract Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials.
    2 sg:doi 10.1016/j.bandl.2015.04.003
    3 sg:doiLink http://dx.doi.org/10.1016/j.bandl.2015.04.003
    4 sg:isFundedPublicationOf grants:2250b8d774ef088e7482e7acc5fed8d7
    5 sg:language English
    6 sg:license http://scigraph.springernature.com/explorer/license/
    7 sg:publicationYear 2015
    8 sg:scigraphId 036a703917bea0843494050b450e6257
    9 sg:title Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study.
    10 sg:volume 145-146
    11 rdf:type sg:Article
    12 rdfs:label Article: Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study.
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