Performance Evaluation and Quantitative Accuracy of Multipinhole NanoSPECT/CT Scanner for Theranostic Lu-177 Imaging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06-08

AUTHORS

Arun Gupta, Kyeong Yun Kim, Donghwi Hwang, Min Sun Lee, Dong Soo Lee, Jae Sung Lee

ABSTRACT

SPECT plays important role in peptide receptor targeted radionuclide therapy using theranostic radionuclides such as Lu-177 for the treatment of various cancers. However, SPECT studies must be quantitatively accurate because the reliable assessment of tumor uptake and tumor-to-normal tissue ratios can only be performed using quantitatively accurate images. Hence, it is important to evaluate performance parameters and quantitative accuracy of preclinical SPECT systems for therapeutic radioisotopes before conducting pre- and post-therapy SPECT imaging or dosimetry studies. In this study, we evaluated system performance and quantitative accuracy of NanoSPECT/CT scanner for Lu-177 imaging using point source and uniform phantom studies. We measured recovery coefficient, uniformity, spatial resolution, system sensitivity and calibration factor for mouse whole body standard aperture. We also performed the experiments using Tc-99m to compare the results with that of Lu-177. We found that the recovery coefficient of more than 70% for Lu-177 at the optimum noise level when nine iterations were used. The spatial resolutions of Lu-177 with and without adding uniform background was comparable to that of Tc-99m in axial, radial and tangential directions. System sensitivity measured for Lu-177 was almost three times less than that of Tc-99m. More... »

PAGES

1379-1386

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.3938/jkps.72.1379

DOI

http://dx.doi.org/10.3938/jkps.72.1379

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104489368


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