Detection and annotation of common post-translational modifications in mass spectrometry data View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Julien Mariethoz , Oliver Horlacher , Frederic Nikitin , Matthew P. Campbell , Nicolle H. Packer , Markus Muller , Frederique Lisacek

ABSTRACT

Glycosylation is probably the most important post-translational modification in terms of the number of proteins modified and the diversity generated. In spite of such a central role in biological processes, the study of glycans remains isolated, protein-carbohydrate interactions are rarely reported in bioinformatics databases and glycomics is lagging behind other -omics. Recent progress in method development for characterising the branched structures of complex carbohydrates has now enabled higher throughput technology. Automation then calls for software development. Adding meaning to large data collections requires corresponding bioinformatics methods and tools. Current glycobioinformatics resources do cover information on the structure and function of glycans, their interaction with proteins or their enzymatic synthesis. However, this information is partial, scattered and often difficult to get to for non-glycobiologists. More... »

PAGES

21-22

Identifiers

URI

http://scigraph.springernature.com/pub.10.3920/978-90-8686-776-9_2

DOI

http://dx.doi.org/10.3920/978-90-8686-776-9_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023444552


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