Role of vitamin D-binding protein in isocyanate-induced occupational asthma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02-08

AUTHORS

Sung-Ho Kim, Gil-Soon Choi, Young-Hee Nam, Joo-Hee Kim, Gyu-Young Hur, Seung-Hyun Kim, Sang Myun Park, Hae-Sim Park

ABSTRACT

The development of a serological marker for early diagnosis of isocyanate-induced occupational asthma (isocyanate-OA) may improve clinical outcome. Our previous proteomic study found that expression of vitamin D-binding protein (VDBP) was upregulated in the patients with isocyanate-OA. In the present study, we evaluated the clinical relevance of VDBP as a serological marker in screening for isocyanate-OA among exposed workers and its role in the pathogenesis of isocyanate-OA. Three study groups including 61 patients with isocyanate-OA (group I), 180 asymptomatic exposed controls (AECs, group II), 58 unexposed healthy controls (NCs, group III) were enrolled in this study. The baseline serum VDBP level was significantly higher in group I compared with groups II and III. The sensitivity and specificity for predicting the phenotype of isocyanate-OA with VDBP were 69% and 81%, respectively. The group I subjects with high VDBP (≥ 311 µg/ml) had significantly lower PC20 methacholine levels than did subjects with low VDBP. The in vitro studies showed that TDI suppressed the uptake of VDBP into RLE-6TN cells, which was mediated by the downregulation of megalin, an endocytic receptor of the 25-hydroxycholecalciferol-VDBP complex. Furthermore, toluene diisocyanate (TDI) increased VEGF production and secretion from this epithelial cells by suppression of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] production. The findings of this study suggest that the serum VDBP level may be used as a serological marker for the detection of isocyanate-OA among workers exposed to isocyanate. The TDI-induced VEGF production/secretion was reversed by 1,25(OH)2D3 treatment, which may provide a potential therapeutic strategy for patients with isocyanate-OA. More... »

PAGES

319-329

References to SciGraph publications

  • 2009. Vitamin D Deficiency and Chronic Lung Disease in CANADIAN RESPIRATORY JOURNAL
  • 2000-06. MAP Kinases and Hypoxia in the Control of VEGF Expression in CANCER AND METASTASIS REVIEWS
  • 1995-07. Establishment of immortalized alveolar type II epithelial cell lines from adult rats in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.3858/emm.2012.44.5.036

    DOI

    http://dx.doi.org/10.3858/emm.2012.44.5.036

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014455430

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22314196


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