Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011

AUTHORS

Gyung Ah Jung, Bong Shik Shin, Yeon Sue Jang, Jae Bum Sohn, Seon Rang Woo, Jung Eun Kim, Go Choi, Kyung-Mi Lee, Bon Hong Min, Kee-Ho Lee, Gil Hong Park

ABSTRACT

Protein arginine methylation is important for a variety of cellular processes including transcriptional regulation, mRNA splicing, DNA repair, nuclear/cytoplasmic shuttling and various signal transduction pathways. However, the role of arginine methylation in protein biosynthesis and the extracellular signals that control arginine methylation are not fully understood. Basic fibroblast growth factor (bFGF) has been identified as a potent stimulator of myofibroblast dedifferentiation into fibroblasts. We demonstrated that symmetric arginine dimethylation of eukaryotic elongation factor 2 (eEF2) is induced by bFGF without the change in the expression level of eEF2 in mouse embryo fibroblast NIH3T3 cells. The eEF2 methylation is preceded by ras-raf-mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK1/2)- p21Cip/WAF1 activation, and suppressed by the mitogenactivated protein kinase (MAPK) inhibitor PD98059 and p21Cip/WAF1 short interfering RNA (siRNA). We determined that protein arginine methyltransferase 7 (PRMT7) is responsible for the methylation, and that PRMT5 acts as a coordinator. Collectively, we demonstrated that eEF2, a key factor involved in protein translational elongation is symmetrically arginine-methylated in a reversible manner, being regulated by bFGF through MAPK signaling pathway. More... »

PAGES

emm201163

Identifiers

URI

http://scigraph.springernature.com/pub.10.3858/emm.2011.43.10.061

DOI

http://dx.doi.org/10.3858/emm.2011.43.10.061

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027970686

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21778808


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

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