Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010

AUTHORS

Jung Min Hong, Tae-Ho Kim, Hyun-Ju Kim, Eui-Kyun Park, Eun-Kyoung Yang, Shin-Yoon Kim

ABSTRACT

Multiple factors have been implicated in the development of osteonecrosis of the femoral head (ONFH). In particular, non-traumatic ONFH is directly or indirectly related to injury of the vascular supply to the femoral head. Thus, hypoxia in the femoral head caused by impaired blood flow may be an important risk factor for ONFH. In this study, we investigated whether genetic variations of angiogenesis- and hypoxia-related genes contribute to an increased risk for the development of ONFH. Candidate genes were selected based on known hypoxia and angiogenesis pathways. An association study was performed using an Affymetrix Targeted Genotyping 3K Chip array with 460 ONFH patients and 300 control subjects. We showed that single nucleotide polymorphisms (SNPs) in the genes TF, VEGFC, IGFBP3, and ACE were associated with an increased risk of ONFH. On the other hand, SNPs in the KDR and NRP1 genes were associated with protection against ONFH. The most important finding was that one SNP (rs2453839) in the IGFBP3 gene was significantly associated with a higher risk of ONFH (P=0.0061, OR 7.74). In subgroup analysis, most candidate gene variations that were associated with ONFH occurred in the idiopathic subgroup. Among other SNPs, ACE SNPs were associated with steroid-induced ONFH (P=0.0018-0.0037, OR>3). Collectively, our findings suggest that genetic variations in angiogenesis- and hypoxia-related genes may help to identify susceptibility factors for the development of ONFH in the Korean population. More... »

PAGES

376

Identifiers

URI

http://scigraph.springernature.com/pub.10.3858/emm.2010.42.5.039

DOI

http://dx.doi.org/10.3858/emm.2010.42.5.039

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039296689

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20215856


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asian Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Femur Head", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Femur Head Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoxia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Korea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteonecrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kyungpook National University", 
          "id": "https://www.grid.ac/institutes/grid.258803.4", 
          "name": [
            "Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea.", 
            "Department of Physiology, Kyungpook National University School of Medicine, Daegu 700-412, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Jung Min", 
        "id": "sg:person.0717632703.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717632703.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyungpook National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411235.0", 
          "name": [
            "Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Tae-Ho", 
        "id": "sg:person.015306603540.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015306603540.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyungpook National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411235.0", 
          "name": [
            "Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyun-Ju", 
        "id": "sg:person.0755412600.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755412600.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyungpook National University", 
          "id": "https://www.grid.ac/institutes/grid.258803.4", 
          "name": [
            "Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea.", 
            "Department of Pathology and Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Eui-Kyun", 
        "id": "sg:person.01035531073.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035531073.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyungpook National University", 
          "id": "https://www.grid.ac/institutes/grid.258803.4", 
          "name": [
            "Department of Physiology, Kyungpook National University School of Medicine, Daegu 700-412, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Eun-Kyoung", 
        "id": "sg:person.01100216367.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100216367.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyungpook National University", 
          "id": "https://www.grid.ac/institutes/grid.258803.4", 
          "name": [
            "Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea.", 
            "Department of Orthopedic Surgery, Kyungpook National University School of Medicine, Daegu 700-712, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Shin-Yoon", 
        "id": "sg:person.01272532313.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272532313.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.joca.2007.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000230536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.050301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001020420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2004.020834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001899822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2003.12.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001963688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2007.04.074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004822459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005974316", 
          "https://doi.org/10.1038/sj.leu.2402534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005974316", 
          "https://doi.org/10.1038/sj.leu.2402534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006081874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m403715200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009179026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001665-200305000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011859310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001665-200305000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011859310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/344207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011986879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/344207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011986879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.136.6.1375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012721161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.061207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018156247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2006.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018510289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006416-200507000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019820178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006416-200507000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019820178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200262070-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020116346", 
          "https://doi.org/10.2165/00003495-200262070-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200262070-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020116346", 
          "https://doi.org/10.2165/00003495-200262070-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-2197.2006.03872.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022483745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m412953200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025419917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4914(01)02090-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026165981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-007-9046-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026844997", 
          "https://doi.org/10.1007/s00223-007-9046-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-007-9046-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026844997", 
          "https://doi.org/10.1007/s00223-007-9046-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028380261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.20441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029739222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/micr.10190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030524713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/9460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030979399", 
          "https://doi.org/10.1038/9460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/9460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030979399", 
          "https://doi.org/10.1038/9460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0070-2153(06)76007-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032399905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2005.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032860318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.18.6.3112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034063303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10623320600904211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035000349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.24.14389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035264605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2003.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036577638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.20097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037172092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004390050667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037552930", 
          "https://doi.org/10.1007/s004390050667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004390050667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037552930", 
          "https://doi.org/10.1007/s004390050667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(01)00663-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044173645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2004.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044253682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joca.2006.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044488100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2007.02431.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045593287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2007.02431.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045593287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.10321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047999564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-006-9265-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052050307", 
          "https://doi.org/10.1007/s10549-006-9265-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-006-9265-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052050307", 
          "https://doi.org/10.1007/s10549-006-9265-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.orthres.2004.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052167418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjhyper.2007.01.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054728185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199810001-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060167504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199810001-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060167504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199810001-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060167504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200105000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200105000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200105000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200408000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060169812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200408000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060169812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200408000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060169812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv-16-1-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.16.1.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064285655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v9.i2.262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071375542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074266799", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.66.6.889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074568777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074687338", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-002-0671-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075240294", 
          "https://doi.org/10.1007/s00441-002-0671-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075336500", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079885663", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010", 
    "datePublishedReg": "2010-01-01", 
    "description": "Multiple factors have been implicated in the development of osteonecrosis of the femoral head (ONFH). In particular, non-traumatic ONFH is directly or indirectly related to injury of the vascular supply to the femoral head. Thus, hypoxia in the femoral head caused by impaired blood flow may be an important risk factor for ONFH. In this study, we investigated whether genetic variations of angiogenesis- and hypoxia-related genes contribute to an increased risk for the development of ONFH. Candidate genes were selected based on known hypoxia and angiogenesis pathways. An association study was performed using an Affymetrix Targeted Genotyping 3K Chip array with 460 ONFH patients and 300 control subjects. We showed that single nucleotide polymorphisms (SNPs) in the genes TF, VEGFC, IGFBP3, and ACE were associated with an increased risk of ONFH. On the other hand, SNPs in the KDR and NRP1 genes were associated with protection against ONFH. The most important finding was that one SNP (rs2453839) in the IGFBP3 gene was significantly associated with a higher risk of ONFH (P=0.0061, OR 7.74). In subgroup analysis, most candidate gene variations that were associated with ONFH occurred in the idiopathic subgroup. Among other SNPs, ACE SNPs were associated with steroid-induced ONFH (P=0.0018-0.0037, OR>3). Collectively, our findings suggest that genetic variations in angiogenesis- and hypoxia-related genes may help to identify susceptibility factors for the development of ONFH in the Korean population.", 
    "genre": "research_article", 
    "id": "sg:pub.10.3858/emm.2010.42.5.039", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1085098", 
        "issn": [
          "1226-3613", 
          "2092-6413"
        ], 
        "name": "Experimental & Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head", 
    "pagination": "376", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bb3043fc1283f2a8d9059b37a1a4feb4d2190dd0e1f020f71d8afeb3abc62f67"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20215856"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9607880"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.3858/emm.2010.42.5.039"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039296689"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.3858/emm.2010.42.5.039", 
      "https://app.dimensions.ai/details/publication/pub.1039296689"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113673_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/emm201039"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.3858/emm.2010.42.5.039'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.3858/emm.2010.42.5.039'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.3858/emm.2010.42.5.039'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.3858/emm.2010.42.5.039'


 

This table displays all metadata directly associated to this object as RDF triples.

326 TRIPLES      21 PREDICATES      95 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.3858/emm.2010.42.5.039 schema:about N21648ded05204b66a0c7c5e25bf92697
2 N235ad49c51c0453ea3ccea19a0c26d02
3 N25f4f3af8dda490a82929f97517690c3
4 N4fa718925c7f4de1b2a476b4591cb8e7
5 N63414c29a76d4e8985fcc9ad6133290e
6 N78eab327eaab4f308676f7ca3cdda61c
7 N840f40a2819947fe865d839cadf40e74
8 N8a7e66b0af9b4450b32da9e354c78c8b
9 N8b7d312353664c9e8831832a4bac386a
10 Na894a710f9d0431189b7572c737ef9c2
11 Nc0b5ca79f399492c9f6a98d15f045124
12 Nc68bc1b3e7964e29adf22dba4046d69c
13 Ne8402f20a5a84e00ad64e4abbe035468
14 Neba8d685349a4a48af8f0cc627de2637
15 Nfba1d65a8e2b4dd7936c0338ce1e25aa
16 anzsrc-for:06
17 anzsrc-for:0604
18 schema:author N35f8eefad3334a46817c40e22c7bd132
19 schema:citation sg:pub.10.1007/s00223-007-9046-9
20 sg:pub.10.1007/s004390050667
21 sg:pub.10.1007/s00441-002-0671-3
22 sg:pub.10.1007/s10549-006-9265-1
23 sg:pub.10.1038/9460
24 sg:pub.10.1038/sj.leu.2402534
25 sg:pub.10.2165/00003495-200262070-00001
26 https://app.dimensions.ai/details/publication/pub.1074266799
27 https://app.dimensions.ai/details/publication/pub.1074687338
28 https://app.dimensions.ai/details/publication/pub.1075336500
29 https://app.dimensions.ai/details/publication/pub.1079885663
30 https://doi.org/10.1002/art.20441
31 https://doi.org/10.1002/jcp.10321
32 https://doi.org/10.1002/jlb.66.6.889
33 https://doi.org/10.1002/jor.20097
34 https://doi.org/10.1002/micr.10190
35 https://doi.org/10.1002/pros.20589
36 https://doi.org/10.1016/j.amjhyper.2007.01.018
37 https://doi.org/10.1016/j.atherosclerosis.2004.11.010
38 https://doi.org/10.1016/j.atherosclerosis.2006.09.014
39 https://doi.org/10.1016/j.bone.2003.06.002
40 https://doi.org/10.1016/j.bone.2003.12.024
41 https://doi.org/10.1016/j.bone.2005.02.003
42 https://doi.org/10.1016/j.jacc.2007.04.074
43 https://doi.org/10.1016/j.joca.2006.12.007
44 https://doi.org/10.1016/j.joca.2007.06.017
45 https://doi.org/10.1016/j.orthres.2004.03.002
46 https://doi.org/10.1016/s0070-2153(06)76007-0
47 https://doi.org/10.1016/s1471-4914(01)02090-1
48 https://doi.org/10.1016/s8756-3282(01)00663-9
49 https://doi.org/10.1073/pnas.95.24.14389
50 https://doi.org/10.1074/jbc.m403715200
51 https://doi.org/10.1074/jbc.m412953200
52 https://doi.org/10.1080/10623320600904211
53 https://doi.org/10.1083/jcb.136.6.1375
54 https://doi.org/10.1086/344207
55 https://doi.org/10.1097/00001665-200305000-00013
56 https://doi.org/10.1097/00003086-199810001-00010
57 https://doi.org/10.1097/00003086-200105000-00004
58 https://doi.org/10.1097/00003086-200408000-00023
59 https://doi.org/10.1097/00006416-200507000-00012
60 https://doi.org/10.1111/j.1445-2197.2006.03872.x
61 https://doi.org/10.1111/j.1538-7836.2007.02431.x
62 https://doi.org/10.1128/mcb.18.6.3112
63 https://doi.org/10.1136/ard.2004.020834
64 https://doi.org/10.1210/edrv-16-1-3
65 https://doi.org/10.1210/er.16.1.3
66 https://doi.org/10.1242/dev.00559
67 https://doi.org/10.1359/jbmr.050301
68 https://doi.org/10.1359/jbmr.061207
69 https://doi.org/10.3748/wjg.v9.i2.262
70 schema:datePublished 2010
71 schema:datePublishedReg 2010-01-01
72 schema:description Multiple factors have been implicated in the development of osteonecrosis of the femoral head (ONFH). In particular, non-traumatic ONFH is directly or indirectly related to injury of the vascular supply to the femoral head. Thus, hypoxia in the femoral head caused by impaired blood flow may be an important risk factor for ONFH. In this study, we investigated whether genetic variations of angiogenesis- and hypoxia-related genes contribute to an increased risk for the development of ONFH. Candidate genes were selected based on known hypoxia and angiogenesis pathways. An association study was performed using an Affymetrix Targeted Genotyping 3K Chip array with 460 ONFH patients and 300 control subjects. We showed that single nucleotide polymorphisms (SNPs) in the genes TF, VEGFC, IGFBP3, and ACE were associated with an increased risk of ONFH. On the other hand, SNPs in the KDR and NRP1 genes were associated with protection against ONFH. The most important finding was that one SNP (rs2453839) in the IGFBP3 gene was significantly associated with a higher risk of ONFH (P=0.0061, OR 7.74). In subgroup analysis, most candidate gene variations that were associated with ONFH occurred in the idiopathic subgroup. Among other SNPs, ACE SNPs were associated with steroid-induced ONFH (P=0.0018-0.0037, OR>3). Collectively, our findings suggest that genetic variations in angiogenesis- and hypoxia-related genes may help to identify susceptibility factors for the development of ONFH in the Korean population.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf Nc3b4dfe0a3604b64ad555abed6ad7d63
77 Nd935c37a0207437ab5e152e7d232c531
78 sg:journal.1085098
79 schema:name Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head
80 schema:pagination 376
81 schema:productId N0cbc159e23144847952002027112577e
82 N140ef19bcfe04bcbbab2b74fa5e52e27
83 N344aa73ebae042db99ab42b7ac6ec8c1
84 N6c626e45ff564f80a46b5ff27f115284
85 Ne29815ff62c5409da4418cbc717ba1f9
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039296689
87 https://doi.org/10.3858/emm.2010.42.5.039
88 schema:sdDatePublished 2019-04-11T10:36
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N0343172274f74ca68da3aaaaa2651ece
91 schema:url https://www.nature.com/articles/emm201039
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N0343172274f74ca68da3aaaaa2651ece schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N0cbc159e23144847952002027112577e schema:name readcube_id
98 schema:value bb3043fc1283f2a8d9059b37a1a4feb4d2190dd0e1f020f71d8afeb3abc62f67
99 rdf:type schema:PropertyValue
100 N140ef19bcfe04bcbbab2b74fa5e52e27 schema:name dimensions_id
101 schema:value pub.1039296689
102 rdf:type schema:PropertyValue
103 N21648ded05204b66a0c7c5e25bf92697 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Female
105 rdf:type schema:DefinedTerm
106 N235ad49c51c0453ea3ccea19a0c26d02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Humans
108 rdf:type schema:DefinedTerm
109 N25f4f3af8dda490a82929f97517690c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Genetic Predisposition to Disease
111 rdf:type schema:DefinedTerm
112 N2d604294fc784ef9a52b0443ce24170b rdf:first sg:person.01035531073.06
113 rdf:rest Nea94985cc3bf4adaa42f3adb7a166f73
114 N344aa73ebae042db99ab42b7ac6ec8c1 schema:name pubmed_id
115 schema:value 20215856
116 rdf:type schema:PropertyValue
117 N35f8eefad3334a46817c40e22c7bd132 rdf:first sg:person.0717632703.81
118 rdf:rest Na844c2fea840439a9188d569877dd6be
119 N4fa718925c7f4de1b2a476b4591cb8e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Middle Aged
121 rdf:type schema:DefinedTerm
122 N63414c29a76d4e8985fcc9ad6133290e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Osteonecrosis
124 rdf:type schema:DefinedTerm
125 N6c626e45ff564f80a46b5ff27f115284 schema:name doi
126 schema:value 10.3858/emm.2010.42.5.039
127 rdf:type schema:PropertyValue
128 N78eab327eaab4f308676f7ca3cdda61c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Asian Continental Ancestry Group
130 rdf:type schema:DefinedTerm
131 N79aee947bb054c5bb47f2645b0075b92 rdf:first sg:person.01272532313.18
132 rdf:rest rdf:nil
133 N840f40a2819947fe865d839cadf40e74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Femur Head Necrosis
135 rdf:type schema:DefinedTerm
136 N8a7e66b0af9b4450b32da9e354c78c8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Hypoxia
138 rdf:type schema:DefinedTerm
139 N8b7d312353664c9e8831832a4bac386a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Adult
141 rdf:type schema:DefinedTerm
142 N9fbf906aca9b4ce0ad69f9bc751b2db2 rdf:first sg:person.0755412600.29
143 rdf:rest N2d604294fc784ef9a52b0443ce24170b
144 Na844c2fea840439a9188d569877dd6be rdf:first sg:person.015306603540.00
145 rdf:rest N9fbf906aca9b4ce0ad69f9bc751b2db2
146 Na894a710f9d0431189b7572c737ef9c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Polymorphism, Single Nucleotide
148 rdf:type schema:DefinedTerm
149 Nc0b5ca79f399492c9f6a98d15f045124 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Male
151 rdf:type schema:DefinedTerm
152 Nc3b4dfe0a3604b64ad555abed6ad7d63 schema:issueNumber 5
153 rdf:type schema:PublicationIssue
154 Nc68bc1b3e7964e29adf22dba4046d69c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Femur Head
156 rdf:type schema:DefinedTerm
157 Nd935c37a0207437ab5e152e7d232c531 schema:volumeNumber 42
158 rdf:type schema:PublicationVolume
159 Ne29815ff62c5409da4418cbc717ba1f9 schema:name nlm_unique_id
160 schema:value 9607880
161 rdf:type schema:PropertyValue
162 Ne8402f20a5a84e00ad64e4abbe035468 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Gene Expression Profiling
164 rdf:type schema:DefinedTerm
165 Nea94985cc3bf4adaa42f3adb7a166f73 rdf:first sg:person.01100216367.82
166 rdf:rest N79aee947bb054c5bb47f2645b0075b92
167 Neba8d685349a4a48af8f0cc627de2637 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Oligonucleotide Array Sequence Analysis
169 rdf:type schema:DefinedTerm
170 Nfba1d65a8e2b4dd7936c0338ce1e25aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Korea
172 rdf:type schema:DefinedTerm
173 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
174 schema:name Biological Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
177 schema:name Genetics
178 rdf:type schema:DefinedTerm
179 sg:journal.1085098 schema:issn 1226-3613
180 2092-6413
181 schema:name Experimental & Molecular Medicine
182 rdf:type schema:Periodical
183 sg:person.01035531073.06 schema:affiliation https://www.grid.ac/institutes/grid.258803.4
184 schema:familyName Park
185 schema:givenName Eui-Kyun
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035531073.06
187 rdf:type schema:Person
188 sg:person.01100216367.82 schema:affiliation https://www.grid.ac/institutes/grid.258803.4
189 schema:familyName Yang
190 schema:givenName Eun-Kyoung
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100216367.82
192 rdf:type schema:Person
193 sg:person.01272532313.18 schema:affiliation https://www.grid.ac/institutes/grid.258803.4
194 schema:familyName Kim
195 schema:givenName Shin-Yoon
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272532313.18
197 rdf:type schema:Person
198 sg:person.015306603540.00 schema:affiliation https://www.grid.ac/institutes/grid.411235.0
199 schema:familyName Kim
200 schema:givenName Tae-Ho
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015306603540.00
202 rdf:type schema:Person
203 sg:person.0717632703.81 schema:affiliation https://www.grid.ac/institutes/grid.258803.4
204 schema:familyName Hong
205 schema:givenName Jung Min
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717632703.81
207 rdf:type schema:Person
208 sg:person.0755412600.29 schema:affiliation https://www.grid.ac/institutes/grid.411235.0
209 schema:familyName Kim
210 schema:givenName Hyun-Ju
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755412600.29
212 rdf:type schema:Person
213 sg:pub.10.1007/s00223-007-9046-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026844997
214 https://doi.org/10.1007/s00223-007-9046-9
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s004390050667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037552930
217 https://doi.org/10.1007/s004390050667
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s00441-002-0671-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075240294
220 https://doi.org/10.1007/s00441-002-0671-3
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s10549-006-9265-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052050307
223 https://doi.org/10.1007/s10549-006-9265-1
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/9460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030979399
226 https://doi.org/10.1038/9460
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/sj.leu.2402534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005974316
229 https://doi.org/10.1038/sj.leu.2402534
230 rdf:type schema:CreativeWork
231 sg:pub.10.2165/00003495-200262070-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020116346
232 https://doi.org/10.2165/00003495-200262070-00001
233 rdf:type schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1074266799 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1074687338 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1075336500 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1079885663 schema:CreativeWork
238 https://doi.org/10.1002/art.20441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029739222
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/jcp.10321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047999564
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/jlb.66.6.889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074568777
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/jor.20097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037172092
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/micr.10190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030524713
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/pros.20589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028380261
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.amjhyper.2007.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054728185
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.atherosclerosis.2004.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044253682
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.atherosclerosis.2006.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018510289
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.bone.2003.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036577638
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.bone.2003.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001963688
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.bone.2005.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032860318
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.jacc.2007.04.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004822459
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.joca.2006.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044488100
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.joca.2007.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000230536
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.orthres.2004.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052167418
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0070-2153(06)76007-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032399905
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s1471-4914(01)02090-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026165981
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s8756-3282(01)00663-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044173645
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1073/pnas.95.24.14389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035264605
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1074/jbc.m403715200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009179026
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1074/jbc.m412953200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025419917
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1080/10623320600904211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035000349
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1083/jcb.136.6.1375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012721161
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1086/344207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011986879
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1097/00001665-200305000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011859310
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1097/00003086-199810001-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060167504
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/00003086-200105000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060168691
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/00003086-200408000-00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060169812
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/00006416-200507000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019820178
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1111/j.1445-2197.2006.03872.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022483745
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1111/j.1538-7836.2007.02431.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045593287
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1128/mcb.18.6.3112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034063303
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1136/ard.2004.020834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001899822
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1210/edrv-16-1-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238097
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1210/er.16.1.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285655
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1242/dev.00559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006081874
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1359/jbmr.050301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001020420
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1359/jbmr.061207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018156247
315 rdf:type schema:CreativeWork
316 https://doi.org/10.3748/wjg.v9.i2.262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071375542
317 rdf:type schema:CreativeWork
318 https://www.grid.ac/institutes/grid.258803.4 schema:alternateName Kyungpook National University
319 schema:name Department of Orthopedic Surgery, Kyungpook National University School of Medicine, Daegu 700-712, Korea.
320 Department of Pathology and Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea.
321 Department of Physiology, Kyungpook National University School of Medicine, Daegu 700-412, Korea.
322 Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea.
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.411235.0 schema:alternateName Kyungpook National University Hospital
325 schema:name Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700-412, Korea.
326 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...