Involvement of βPIX in angiotensin II-induced migration of vascular smooth muscle cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009

AUTHORS

Eun-Young Shin, Chan-Soo Lee, Mee-Hee Park, Duk-Joong Kim, Sahng-June Kwak, Eung-Gook Kim

ABSTRACT

Angiotensin II (Ang II) stimulates migration of vascular smooth muscle cell (VSMC) in addition to its contribution to contraction and hypertrophy. It is well established that Rho GTPases regulate cellular contractility and migration by reorganizing the actin cytoskeleton. Ang II activates Rac1 GTPase, but its upstream guanine nucleotide exchange factor (GEF) remains elusive. Here, we show that Ang II-induced VSMC migration occurs in a betaPIX GEF-dependent manner. betaPIX-specific siRNA treatment significantly inhibited Ang II-induced VSMC migration. Ang II activated the catalytic activity of betaPIX towards Rac1 in dose- and time-dependent manners. Activity reached a peak at 10 min and declined close to a basal level by 30 min following stimulation. Pharmacological inhibition with specific kinase inhibitors revealed the participation of protein kinase C, Src family kinase, and phosphatidylinositol 3-kinase (PI3-K) upstream of betaPIX. Both p21-activated kinase and reactive oxygen species played key roles in cytoskeletal reorganization downstream of betaPIX-Rac1. Taken together, our results suggest that betaPIX is involved in Ang II-induced VSMC migration. More... »

PAGES

387

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.3858/emm.2009.41.6.044

DOI

http://dx.doi.org/10.3858/emm.2009.41.6.044

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003008484

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19322025


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guanine Nucleotide Exchange Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocytes, Smooth Muscle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NADPH Oxidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rho Guanine Nucleotide Exchange Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "p21-Activated Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "rac1 GTP-Binding Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src-Family Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chungbuk National University", 
          "id": "https://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "Department of Biochemistry and Signaling Disorder Research Center, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Eun-Young", 
        "id": "sg:person.010546405112.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010546405112.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungbuk National University", 
          "id": "https://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "Department of Biochemistry and Signaling Disorder Research Center, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Chan-Soo", 
        "id": "sg:person.01224452425.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224452425.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungbuk National University", 
          "id": "https://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "Department of Biochemistry and Signaling Disorder Research Center, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Mee-Hee", 
        "id": "sg:person.01030166337.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030166337.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungbuk National University", 
          "id": "https://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "Department of Biochemistry and Signaling Disorder Research Center, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Duk-Joong", 
        "id": "sg:person.0731400240.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731400240.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "Department of Biochemistry College of Medicine, Dankook University, Cheonan 330-714, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwak", 
        "givenName": "Sahng-June", 
        "id": "sg:person.0771422613.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771422613.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungbuk National University", 
          "id": "https://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "Department of Biochemistry and Signaling Disorder Research Center, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Eung-Gook", 
        "id": "sg:person.01266456772.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266456772.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.atv.0000175295.09607.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001015897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000175295.09607.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001015897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.104.010637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001164397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000059987.90200.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001920141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000059987.90200.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001920141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20060342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002966525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20060342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002966525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e06-03-0207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006172168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m102450200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011681978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddn248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015085950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.2006.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018217203", 
          "https://doi.org/10.1038/emm.2006.60"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.2006.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018217203", 
          "https://doi.org/10.1038/emm.2006.60"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m602399200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018363513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200509096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021067581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00287.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023776104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20051655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024454349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20051655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024454349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000142313.68389.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024528380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000142313.68389.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024528380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.46.32565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024562006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2006.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025372113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.6.2160-2174.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025991487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m512751200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028586641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000132400.25045.2a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028772181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000132400.25045.2a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028772181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0510444103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030196909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m307330200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030980991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejcb.2005.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032940895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033615963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034463855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000175749.41799.9b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036226120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000175749.41799.9b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036226120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m203754200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040676123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80019-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041310235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.9.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041827950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m302960200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042080889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00004.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043470190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m708034200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045882556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046102387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.10.4384-4394.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046744424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m212892200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046921037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5350.509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047090124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000126848.54740.4a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048395521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000126848.54740.4a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048395521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000033523.08033.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048627973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m513665200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050188586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0307512101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050728633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00448.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052245282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00448.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052245282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.2845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053699693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1092571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062449202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1979.59.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074658947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082757913", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009", 
    "datePublishedReg": "2009-01-01", 
    "description": "Angiotensin II (Ang II) stimulates migration of vascular smooth muscle cell (VSMC) in addition to its contribution to contraction and hypertrophy. It is well established that Rho GTPases regulate cellular contractility and migration by reorganizing the actin cytoskeleton. Ang II activates Rac1 GTPase, but its upstream guanine nucleotide exchange factor (GEF) remains elusive. Here, we show that Ang II-induced VSMC migration occurs in a betaPIX GEF-dependent manner. betaPIX-specific siRNA treatment significantly inhibited Ang II-induced VSMC migration. Ang II activated the catalytic activity of betaPIX towards Rac1 in dose- and time-dependent manners. Activity reached a peak at 10 min and declined close to a basal level by 30 min following stimulation. Pharmacological inhibition with specific kinase inhibitors revealed the participation of protein kinase C, Src family kinase, and phosphatidylinositol 3-kinase (PI3-K) upstream of betaPIX. Both p21-activated kinase and reactive oxygen species played key roles in cytoskeletal reorganization downstream of betaPIX-Rac1. Taken together, our results suggest that betaPIX is involved in Ang II-induced VSMC migration.", 
    "genre": "research_article", 
    "id": "sg:pub.10.3858/emm.2009.41.6.044", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1085098", 
        "issn": [
          "1226-3613", 
          "2092-6413"
        ], 
        "name": "Experimental & Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "name": "Involvement of \u03b2PIX in angiotensin II-induced migration of vascular smooth muscle cells", 
    "pagination": "387", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0e53ff9c9cfd7d08aad3016ac0204788ec44794b80e2a9f819a210216934c25b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19322025"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9607880"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.3858/emm.2009.41.6.044"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003008484"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.3858/emm.2009.41.6.044", 
      "https://app.dimensions.ai/details/publication/pub.1003008484"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000345_0000000345/records_64091_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/emm200946"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.3858/emm.2009.41.6.044'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.3858/emm.2009.41.6.044'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.3858/emm.2009.41.6.044'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.3858/emm.2009.41.6.044'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      21 PREDICATES      89 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.3858/emm.2009.41.6.044 schema:about N053744c98874475fa8f25b123ff627ca
2 N38bf1bd4a9114b2fa181208a3c0a6578
3 N423adcab56144931927e072953678981
4 N5cae421f05be46a686af9a8d495a31d3
5 N62ec5353ae56495d989a5b90c4c900ea
6 N770e809f49b84e589654b474c89c2244
7 N7828e22785d041969d1d9279de92c57e
8 Na05a5fd359b1422681d65988e4d2366a
9 Na93c239a7b9144b9a636c1aac07d3988
10 Nad580fb6a3644c70a48ec91ee1c350c4
11 Nc109890b832c496fb7720d7f78ada794
12 Nc8a679508e794b478c2e63827655cb47
13 Nc9be006136944be2ac7369e662e54102
14 Ndd48b97786ae4c4e918d50ad0e287a26
15 Ne1250bfd219649bbbb089d1b8f809c8a
16 Ne78d42692c964df282266706f7ab25cc
17 Nf7a5fd9717404874a68e0006e4bf1c1a
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N583394a2cc4f455ba3b01481836993af
21 schema:citation sg:pub.10.1038/emm.2006.60
22 https://app.dimensions.ai/details/publication/pub.1082757913
23 https://doi.org/10.1006/bbrc.2000.2845
24 https://doi.org/10.1016/j.ejcb.2005.10.007
25 https://doi.org/10.1016/j.tcb.2006.08.006
26 https://doi.org/10.1016/s1097-2765(00)80019-2
27 https://doi.org/10.1042/bj20051655
28 https://doi.org/10.1042/cs20060342
29 https://doi.org/10.1073/pnas.0307512101
30 https://doi.org/10.1073/pnas.0510444103
31 https://doi.org/10.1074/jbc.274.46.32565
32 https://doi.org/10.1074/jbc.m102450200
33 https://doi.org/10.1074/jbc.m203754200
34 https://doi.org/10.1074/jbc.m212892200
35 https://doi.org/10.1074/jbc.m302960200
36 https://doi.org/10.1074/jbc.m307330200
37 https://doi.org/10.1074/jbc.m512751200
38 https://doi.org/10.1074/jbc.m513665200
39 https://doi.org/10.1074/jbc.m602399200
40 https://doi.org/10.1074/jbc.m708034200
41 https://doi.org/10.1083/jcb.200509096
42 https://doi.org/10.1091/mbc.e06-03-0207
43 https://doi.org/10.1093/emboj/19.9.2008
44 https://doi.org/10.1093/hmg/ddn248
45 https://doi.org/10.1124/mol.104.010637
46 https://doi.org/10.1126/science.1092571
47 https://doi.org/10.1126/science.279.5350.509
48 https://doi.org/10.1128/mcb.24.10.4384-4394.2004
49 https://doi.org/10.1128/mcb.26.6.2160-2174.2006
50 https://doi.org/10.1152/ajpcell.00287.2006
51 https://doi.org/10.1152/ajpcell.00448.2004
52 https://doi.org/10.1152/physiol.00004.2006
53 https://doi.org/10.1152/physrev.1979.59.1.1
54 https://doi.org/10.1161/01.atv.0000132400.25045.2a
55 https://doi.org/10.1161/01.atv.0000175295.09607.18
56 https://doi.org/10.1161/01.atv.0000175749.41799.9b
57 https://doi.org/10.1161/01.res.0000033523.08033.16
58 https://doi.org/10.1161/01.res.0000059987.90200.44
59 https://doi.org/10.1161/01.res.0000126848.54740.4a
60 https://doi.org/10.1161/01.res.0000142313.68389.92
61 https://doi.org/10.1242/jcs.02385
62 https://doi.org/10.1242/jcs.02996
63 https://doi.org/10.1371/journal.pgen.1000269
64 schema:datePublished 2009
65 schema:datePublishedReg 2009-01-01
66 schema:description Angiotensin II (Ang II) stimulates migration of vascular smooth muscle cell (VSMC) in addition to its contribution to contraction and hypertrophy. It is well established that Rho GTPases regulate cellular contractility and migration by reorganizing the actin cytoskeleton. Ang II activates Rac1 GTPase, but its upstream guanine nucleotide exchange factor (GEF) remains elusive. Here, we show that Ang II-induced VSMC migration occurs in a betaPIX GEF-dependent manner. betaPIX-specific siRNA treatment significantly inhibited Ang II-induced VSMC migration. Ang II activated the catalytic activity of betaPIX towards Rac1 in dose- and time-dependent manners. Activity reached a peak at 10 min and declined close to a basal level by 30 min following stimulation. Pharmacological inhibition with specific kinase inhibitors revealed the participation of protein kinase C, Src family kinase, and phosphatidylinositol 3-kinase (PI3-K) upstream of betaPIX. Both p21-activated kinase and reactive oxygen species played key roles in cytoskeletal reorganization downstream of betaPIX-Rac1. Taken together, our results suggest that betaPIX is involved in Ang II-induced VSMC migration.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N011183ef0b0b45eea1c571666afff528
71 N903d13b805664e4995468198a8f9d05c
72 sg:journal.1085098
73 schema:name Involvement of βPIX in angiotensin II-induced migration of vascular smooth muscle cells
74 schema:pagination 387
75 schema:productId N0317ac208e2540ee834d6ae08c4f21a7
76 N13a67d0ebf554f08a70cb1ee035e3558
77 N30f66f3f5ff5449b8fa84e24d8755708
78 Nc9e4a3d4f2ad454eabd0b36298636038
79 Ne18771d4750949e5803bdcd119b6d14e
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003008484
81 https://doi.org/10.3858/emm.2009.41.6.044
82 schema:sdDatePublished 2019-04-11T09:23
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Ncffdfe58d4954114a6550305ce88a768
85 schema:url https://www.nature.com/articles/emm200946
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N011183ef0b0b45eea1c571666afff528 schema:volumeNumber 41
90 rdf:type schema:PublicationVolume
91 N0317ac208e2540ee834d6ae08c4f21a7 schema:name readcube_id
92 schema:value 0e53ff9c9cfd7d08aad3016ac0204788ec44794b80e2a9f819a210216934c25b
93 rdf:type schema:PropertyValue
94 N053744c98874475fa8f25b123ff627ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Rats
96 rdf:type schema:DefinedTerm
97 N13a67d0ebf554f08a70cb1ee035e3558 schema:name dimensions_id
98 schema:value pub.1003008484
99 rdf:type schema:PropertyValue
100 N30f66f3f5ff5449b8fa84e24d8755708 schema:name doi
101 schema:value 10.3858/emm.2009.41.6.044
102 rdf:type schema:PropertyValue
103 N38bf1bd4a9114b2fa181208a3c0a6578 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Cells, Cultured
105 rdf:type schema:DefinedTerm
106 N423adcab56144931927e072953678981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cell Movement
108 rdf:type schema:DefinedTerm
109 N583394a2cc4f455ba3b01481836993af rdf:first sg:person.010546405112.63
110 rdf:rest N5dcac98e381b4c4c8469239585f5e7d6
111 N5cae421f05be46a686af9a8d495a31d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Animals
113 rdf:type schema:DefinedTerm
114 N5dcac98e381b4c4c8469239585f5e7d6 rdf:first sg:person.01224452425.68
115 rdf:rest Nfa716099274e47399ab5219e36ec6a66
116 N62ec5353ae56495d989a5b90c4c900ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Muscle, Smooth, Vascular
118 rdf:type schema:DefinedTerm
119 N770e809f49b84e589654b474c89c2244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Phosphatidylinositol 3-Kinases
121 rdf:type schema:DefinedTerm
122 N7828e22785d041969d1d9279de92c57e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name p21-Activated Kinases
124 rdf:type schema:DefinedTerm
125 N865d430511774a42963feb957354406e rdf:first sg:person.01266456772.16
126 rdf:rest rdf:nil
127 N903d13b805664e4995468198a8f9d05c schema:issueNumber 6
128 rdf:type schema:PublicationIssue
129 Na05a5fd359b1422681d65988e4d2366a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name rac1 GTP-Binding Protein
131 rdf:type schema:DefinedTerm
132 Na93c239a7b9144b9a636c1aac07d3988 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name RNA, Small Interfering
134 rdf:type schema:DefinedTerm
135 Nad580fb6a3644c70a48ec91ee1c350c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Guanine Nucleotide Exchange Factors
137 rdf:type schema:DefinedTerm
138 Nc109890b832c496fb7720d7f78ada794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name NADPH Oxidases
140 rdf:type schema:DefinedTerm
141 Nc8a679508e794b478c2e63827655cb47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Angiotensin II
143 rdf:type schema:DefinedTerm
144 Nc9be006136944be2ac7369e662e54102 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Rats, Sprague-Dawley
146 rdf:type schema:DefinedTerm
147 Nc9e4a3d4f2ad454eabd0b36298636038 schema:name nlm_unique_id
148 schema:value 9607880
149 rdf:type schema:PropertyValue
150 Ncffdfe58d4954114a6550305ce88a768 schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 Ndd48b97786ae4c4e918d50ad0e287a26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name src-Family Kinases
154 rdf:type schema:DefinedTerm
155 Ne1250bfd219649bbbb089d1b8f809c8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Protein Kinase C
157 rdf:type schema:DefinedTerm
158 Ne18771d4750949e5803bdcd119b6d14e schema:name pubmed_id
159 schema:value 19322025
160 rdf:type schema:PropertyValue
161 Ne78d42692c964df282266706f7ab25cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Myocytes, Smooth Muscle
163 rdf:type schema:DefinedTerm
164 Nef68ff415af3425c92bdbcadd7043d1a rdf:first sg:person.0771422613.08
165 rdf:rest N865d430511774a42963feb957354406e
166 Nf7a5fd9717404874a68e0006e4bf1c1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Rho Guanine Nucleotide Exchange Factors
168 rdf:type schema:DefinedTerm
169 Nfa716099274e47399ab5219e36ec6a66 rdf:first sg:person.01030166337.48
170 rdf:rest Nfc93b70b789d494f9051882c2596789c
171 Nfc93b70b789d494f9051882c2596789c rdf:first sg:person.0731400240.24
172 rdf:rest Nef68ff415af3425c92bdbcadd7043d1a
173 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
174 schema:name Biological Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biochemistry and Cell Biology
178 rdf:type schema:DefinedTerm
179 sg:journal.1085098 schema:issn 1226-3613
180 2092-6413
181 schema:name Experimental & Molecular Medicine
182 rdf:type schema:Periodical
183 sg:person.01030166337.48 schema:affiliation https://www.grid.ac/institutes/grid.254229.a
184 schema:familyName Park
185 schema:givenName Mee-Hee
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030166337.48
187 rdf:type schema:Person
188 sg:person.010546405112.63 schema:affiliation https://www.grid.ac/institutes/grid.254229.a
189 schema:familyName Shin
190 schema:givenName Eun-Young
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010546405112.63
192 rdf:type schema:Person
193 sg:person.01224452425.68 schema:affiliation https://www.grid.ac/institutes/grid.254229.a
194 schema:familyName Lee
195 schema:givenName Chan-Soo
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224452425.68
197 rdf:type schema:Person
198 sg:person.01266456772.16 schema:affiliation https://www.grid.ac/institutes/grid.254229.a
199 schema:familyName Kim
200 schema:givenName Eung-Gook
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266456772.16
202 rdf:type schema:Person
203 sg:person.0731400240.24 schema:affiliation https://www.grid.ac/institutes/grid.254229.a
204 schema:familyName Kim
205 schema:givenName Duk-Joong
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731400240.24
207 rdf:type schema:Person
208 sg:person.0771422613.08 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
209 schema:familyName Kwak
210 schema:givenName Sahng-June
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771422613.08
212 rdf:type schema:Person
213 sg:pub.10.1038/emm.2006.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018217203
214 https://doi.org/10.1038/emm.2006.60
215 rdf:type schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1082757913 schema:CreativeWork
217 https://doi.org/10.1006/bbrc.2000.2845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053699693
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.ejcb.2005.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032940895
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.tcb.2006.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025372113
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s1097-2765(00)80019-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041310235
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1042/bj20051655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024454349
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1042/cs20060342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002966525
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1073/pnas.0307512101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050728633
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1073/pnas.0510444103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030196909
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1074/jbc.274.46.32565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024562006
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1074/jbc.m102450200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011681978
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1074/jbc.m203754200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040676123
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1074/jbc.m212892200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046921037
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.m302960200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042080889
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1074/jbc.m307330200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030980991
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1074/jbc.m512751200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028586641
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1074/jbc.m513665200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050188586
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1074/jbc.m602399200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018363513
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1074/jbc.m708034200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045882556
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1083/jcb.200509096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021067581
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1091/mbc.e06-03-0207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006172168
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/emboj/19.9.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041827950
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/hmg/ddn248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015085950
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1124/mol.104.010637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001164397
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1126/science.1092571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449202
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1126/science.279.5350.509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047090124
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1128/mcb.24.10.4384-4394.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046744424
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1128/mcb.26.6.2160-2174.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025991487
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1152/ajpcell.00287.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023776104
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1152/ajpcell.00448.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052245282
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1152/physiol.00004.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043470190
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1152/physrev.1979.59.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074658947
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1161/01.atv.0000132400.25045.2a schema:sameAs https://app.dimensions.ai/details/publication/pub.1028772181
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1161/01.atv.0000175295.09607.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001015897
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1161/01.atv.0000175749.41799.9b schema:sameAs https://app.dimensions.ai/details/publication/pub.1036226120
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1161/01.res.0000033523.08033.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048627973
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1161/01.res.0000059987.90200.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001920141
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1161/01.res.0000126848.54740.4a schema:sameAs https://app.dimensions.ai/details/publication/pub.1048395521
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1161/01.res.0000142313.68389.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024528380
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1242/jcs.02385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034463855
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1242/jcs.02996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033615963
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1371/journal.pgen.1000269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046102387
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.254229.a schema:alternateName Chungbuk National University
300 schema:name Department of Biochemistry and Signaling Disorder Research Center, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea.
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.411982.7 schema:alternateName Dankook University
303 schema:name Department of Biochemistry College of Medicine, Dankook University, Cheonan 330-714, Korea.
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...