Alterations of epinephrine-induced gluconeogenesis in aging View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-05-29

AUTHORS

Kyungtae Kim, Sung Chun Cho, Anthony Cova, Ik Soon Jang, Sang Chul Park

ABSTRACT

The effects of glucagon and epinephrine on gluconeogenesis in young (4 month) and old (24 month) Fisher 344 rat hepatocytes were compared. In contrast to glucagon, which had a similar effect on gluconeogenesis in both young and old cells, epinephrine caused a smaller increase in gluconeogenesis in old rat hepatocytes than in young hepatocytes. β2 adrenergic receptor (β2-AR) expression slightly decreased in aged rat liver, and there were differences between young and old hepatocytes in their patterns of G protein coupled receptor kinases, which are involved in the activation of β2-AR receptor signal desensitization. The major isoform of the kinase changed from GRK2 to GRK3 and the expression of β-arrestin, which is recruited by the phosphorylated β2-AR for internalization and degradation, increased in aged rat liver. GRK3 overexpression also decreased the glucose output from young rat hepatocytes. We conclude that an age-associated reduction in epinephrine-induced gluconeogenesis occurs through the epinephrine receptor desensitizing system. More... »

PAGES

334-340

Identifiers

URI

http://scigraph.springernature.com/pub.10.3858/emm.2009.41.5.037

DOI

http://dx.doi.org/10.3858/emm.2009.41.5.037

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014689205

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19307753


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