Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-10

AUTHORS

C. Pelosini, M. Maffei, G. Ceccarini, M. Marchi, A. Marsili, G. Galli, G. Scartabelli, A. Tamberi, F. Latrofa, P. Fierabracci, P. Vitti, A. Pinchera, F. Santini

ABSTRACT

BACKGROUND: GPR7, the endogenous coupled receptor for neuropeptide B and neuropeptide W, is expressed in several regions of the central nervous system, which are involved in the regulation of feeding behavior. GPR7 affects the regulation of energy balance through a mechanism independent of leptin and melanocortin pathways. AIM: Aim of this study was to investigate whether GPR7 gene mutations can be detected in human subjects and, in that event, if they are differently distributed among lean and obese subjects. SUBJECTS AND METHODS: The coding region of GPR7 were sequenced in 150 obese patients and 100 normal-weight unrelated controls. Functional studies of the allelic variants were performed. RESULTS: One genetic GPR7 variant was found (Tyr135Phe - rs33977775) in obese subjects (13.3%) and lean control (25%). Functional studies did not reveal significant differences between the wild type and the Tyr135Phe allelic variants in their NPW-mediated capacity to inhibit forskolin-induced cAMP production. CONCLUSIONS: Screening of GPR7 gene mutations among lean and obese subjects revealed a Tyr135Phe allelic variant that was fairly common in the study population. As indicated by in vitro and in silico studies, this variant is unlikely to cause a functional derangement of the receptor. More... »

PAGES

712-715

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.3275/8929

DOI

http://dx.doi.org/10.3275/8929

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1078713510

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23563248


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Substitution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "COS Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cercopithecus aethiops", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, G-Protein-Coupled", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Neuropeptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thinness", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pelosini", 
        "givenName": "C.", 
        "id": "sg:person.0661622357.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661622357.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy", 
            "Dulbecco Telethon Institute, Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy", 
            "IFC CNR, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maffei", 
        "givenName": "M.", 
        "id": "sg:person.0631021407.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631021407.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ceccarini", 
        "givenName": "G.", 
        "id": "sg:person.01171104613.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171104613.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy", 
            "Dulbecco Telethon Institute, Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchi", 
        "givenName": "M.", 
        "id": "sg:person.01277261021.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277261021.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marsili", 
        "givenName": "A.", 
        "id": "sg:person.0722053123.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722053123.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galli", 
        "givenName": "G.", 
        "id": "sg:person.01120107407.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120107407.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scartabelli", 
        "givenName": "G.", 
        "id": "sg:person.01260332426.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260332426.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamberi", 
        "givenName": "A.", 
        "id": "sg:person.0622461715.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622461715.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Latrofa", 
        "givenName": "F.", 
        "id": "sg:person.0660241732.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660241732.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fierabracci", 
        "givenName": "P.", 
        "id": "sg:person.01302451207.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302451207.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vitti", 
        "givenName": "P.", 
        "id": "sg:person.0777360014.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777360014.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinchera", 
        "givenName": "A.", 
        "id": "sg:person.01344402654.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344402654.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santini", 
        "givenName": "F.", 
        "id": "sg:person.01226525757.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226525757.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m206396200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000466060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1995.1109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004298436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0020188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016317418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-08-0734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023360961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10038-005-0238-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023389969", 
          "https://doi.org/10.1007/s10038-005-0238-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2423(09)48004-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024669948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0016972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026097230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m205337200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026976338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0837789100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031145550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn20041143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039932642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1334189100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042243432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkj518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042952078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddl215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049696141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2006-0040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064285877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2008-1595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064290899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2010-2515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.85.3.1001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064301280"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-10", 
    "datePublishedReg": "2013-10-01", 
    "description": "BACKGROUND: GPR7, the endogenous coupled receptor for neuropeptide B and neuropeptide W, is expressed in several regions of the central nervous system, which are involved in the regulation of feeding behavior. GPR7 affects the regulation of energy balance through a mechanism independent of leptin and melanocortin pathways.\nAIM: Aim of this study was to investigate whether GPR7 gene mutations can be detected in human subjects and, in that event, if they are differently distributed among lean and obese subjects.\nSUBJECTS AND METHODS: The coding region of GPR7 were sequenced in 150 obese patients and 100 normal-weight unrelated controls. Functional studies of the allelic variants were performed.\nRESULTS: One genetic GPR7 variant was found (Tyr135Phe - rs33977775) in obese subjects (13.3%) and lean control (25%). Functional studies did not reveal significant differences between the wild type and the Tyr135Phe allelic variants in their NPW-mediated capacity to inhibit forskolin-induced cAMP production.\nCONCLUSIONS: Screening of GPR7 gene mutations among lean and obese subjects revealed a Tyr135Phe allelic variant that was fairly common in the study population. As indicated by in vitro and in silico studies, this variant is unlikely to cause a functional derangement of the receptor.", 
    "genre": "research_article", 
    "id": "sg:pub.10.3275/8929", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5147138", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1088396", 
        "issn": [
          "0391-4097", 
          "1720-8386"
        ], 
        "name": "Journal of Endocrinological Investigation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects", 
    "pagination": "712-715", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cc410415d496eb0155e2cdd3f635688f4f128b80b3a774aebc19eadb3c8579ef"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23563248"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806594"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.3275/8929"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1078713510"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.3275/8929", 
      "https://app.dimensions.ai/details/publication/pub.1078713510"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000508.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.3275/8929"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.3275/8929'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.3275/8929'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.3275/8929'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.3275/8929'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      60 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.3275/8929 schema:about N014f5acac40f4a919e0fc1f12fc632d9
2 N062d02fdb67d48cc8573bc0f47ac8e14
3 N087a5d5c85034cf882fe93d012dc15a9
4 N1746b8df3f38485d85b7c7d4d44fb193
5 N1c51698db39b4ade9e77fd276d256712
6 N1d990b9abafd461984741f81e92c5786
7 N1fb6ee6a9c814be0aaa4cdd3d8244310
8 N2e64e3c7fa594ea696275d27cb60f6e0
9 N632666b149b049d6b77bf6b06968d688
10 N8b47eec982fd4039991f0de2939e6246
11 Nb2b57b9ba0914956ba6e534f1b04a051
12 Ndda38637954947ef80a6399c55ac8e4c
13 Ndf5f32c38c4e4f83acf6143659eacf22
14 Nf2f10053ddfc4b30b22a3cdeba338572
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author Nef9bd58d6db044e286fa178cb096caf7
18 schema:citation sg:pub.10.1007/s10038-005-0238-8
19 https://doi.org/10.1006/geno.1995.1109
20 https://doi.org/10.1016/s0065-2423(09)48004-1
21 https://doi.org/10.1073/pnas.0837789100
22 https://doi.org/10.1073/pnas.1334189100
23 https://doi.org/10.1074/jbc.m205337200
24 https://doi.org/10.1074/jbc.m206396200
25 https://doi.org/10.1079/bjn20041143
26 https://doi.org/10.1093/hmg/ddl215
27 https://doi.org/10.1093/nar/gkj518
28 https://doi.org/10.1210/er.2006-0040
29 https://doi.org/10.1210/jc.2008-1595
30 https://doi.org/10.1210/jc.2010-2515
31 https://doi.org/10.1210/jc.85.3.1001
32 https://doi.org/10.1371/journal.pgen.0020188
33 https://doi.org/10.1371/journal.pone.0016972
34 https://doi.org/10.1530/eje-08-0734
35 schema:datePublished 2013-10
36 schema:datePublishedReg 2013-10-01
37 schema:description BACKGROUND: GPR7, the endogenous coupled receptor for neuropeptide B and neuropeptide W, is expressed in several regions of the central nervous system, which are involved in the regulation of feeding behavior. GPR7 affects the regulation of energy balance through a mechanism independent of leptin and melanocortin pathways. AIM: Aim of this study was to investigate whether GPR7 gene mutations can be detected in human subjects and, in that event, if they are differently distributed among lean and obese subjects. SUBJECTS AND METHODS: The coding region of GPR7 were sequenced in 150 obese patients and 100 normal-weight unrelated controls. Functional studies of the allelic variants were performed. RESULTS: One genetic GPR7 variant was found (Tyr135Phe - rs33977775) in obese subjects (13.3%) and lean control (25%). Functional studies did not reveal significant differences between the wild type and the Tyr135Phe allelic variants in their NPW-mediated capacity to inhibit forskolin-induced cAMP production. CONCLUSIONS: Screening of GPR7 gene mutations among lean and obese subjects revealed a Tyr135Phe allelic variant that was fairly common in the study population. As indicated by in vitro and in silico studies, this variant is unlikely to cause a functional derangement of the receptor.
38 schema:genre research_article
39 schema:inLanguage en
40 schema:isAccessibleForFree false
41 schema:isPartOf N1be72a921a0a45a6b5a5a2f5db3245e7
42 N7e49bd95897a4124b00df8d8b4cec9f6
43 sg:journal.1088396
44 schema:name Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects
45 schema:pagination 712-715
46 schema:productId N02490b8f267246b182af6c097caa3f12
47 N36869b5ec43746a4842b9e70a79ee3e5
48 N3bb0bb56a52b42398fe5d54966421318
49 Nbaea01b796994b3da4615d02278faa57
50 Nfba2cded94ad49c482019453da8ef663
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078713510
52 https://doi.org/10.3275/8929
53 schema:sdDatePublished 2019-04-10T16:41
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher Nd8102a4cf2b145b48f0f1ee3cc995e0e
56 schema:url http://link.springer.com/10.3275/8929
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N014f5acac40f4a919e0fc1f12fc632d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Alleles
62 rdf:type schema:DefinedTerm
63 N019049a35c404c40981d572bf6f6e75a schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
64 rdf:type schema:Organization
65 N02490b8f267246b182af6c097caa3f12 schema:name doi
66 schema:value 10.3275/8929
67 rdf:type schema:PropertyValue
68 N0467a03db83345a38e4cacff53f8a08f rdf:first sg:person.0622461715.77
69 rdf:rest Ne2ee984afa2440789981bdfecd53d7a0
70 N062d02fdb67d48cc8573bc0f47ac8e14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Receptors, Neuropeptide
72 rdf:type schema:DefinedTerm
73 N087a5d5c85034cf882fe93d012dc15a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Cercopithecus aethiops
75 rdf:type schema:DefinedTerm
76 N154faf6de557449abaf1161874f25e20 schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
77 rdf:type schema:Organization
78 N1746b8df3f38485d85b7c7d4d44fb193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Middle Aged
80 rdf:type schema:DefinedTerm
81 N1be72a921a0a45a6b5a5a2f5db3245e7 schema:issueNumber 9
82 rdf:type schema:PublicationIssue
83 N1c51698db39b4ade9e77fd276d256712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name COS Cells
85 rdf:type schema:DefinedTerm
86 N1d990b9abafd461984741f81e92c5786 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Amino Acid Substitution
88 rdf:type schema:DefinedTerm
89 N1fb6ee6a9c814be0aaa4cdd3d8244310 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Thinness
91 rdf:type schema:DefinedTerm
92 N2092c52cd7b64909a43b69db6b7d8a8c schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
93 rdf:type schema:Organization
94 N2e64e3c7fa594ea696275d27cb60f6e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Adult
96 rdf:type schema:DefinedTerm
97 N2f9c8bcbabd94ce4ae788ea5084195aa schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
98 rdf:type schema:Organization
99 N3645c49e92a14a90b8231e1b04e069d8 rdf:first sg:person.0631021407.67
100 rdf:rest N4325ef723b0841928ce2af149a07b7bf
101 N36869b5ec43746a4842b9e70a79ee3e5 schema:name readcube_id
102 schema:value cc410415d496eb0155e2cdd3f635688f4f128b80b3a774aebc19eadb3c8579ef
103 rdf:type schema:PropertyValue
104 N383d1588bed947708c7f572a5c58dbb2 rdf:first sg:person.01344402654.02
105 rdf:rest N4072561d998d4b829d3004e9c596e937
106 N3bb0bb56a52b42398fe5d54966421318 schema:name nlm_unique_id
107 schema:value 7806594
108 rdf:type schema:PropertyValue
109 N4072561d998d4b829d3004e9c596e937 rdf:first sg:person.01226525757.06
110 rdf:rest rdf:nil
111 N4325ef723b0841928ce2af149a07b7bf rdf:first sg:person.01171104613.28
112 rdf:rest Nf088dfaca4f0411fbabd3985e86f97be
113 N4523cb996b8142dabfaf844970de7207 schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
114 rdf:type schema:Organization
115 N4a7423cc97374c25bfda4516d891f3a9 schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
116 rdf:type schema:Organization
117 N50042b6407564b72931aebdaf7791876 rdf:first sg:person.0722053123.04
118 rdf:rest N826b53fc2f1b4ec3bfbdf402936bc5b7
119 N632666b149b049d6b77bf6b06968d688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 N7da16b37e2f14ab7a1bc6fc69bfb6e75 schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
123 rdf:type schema:Organization
124 N7e49bd95897a4124b00df8d8b4cec9f6 schema:volumeNumber 36
125 rdf:type schema:PublicationVolume
126 N826b53fc2f1b4ec3bfbdf402936bc5b7 rdf:first sg:person.01120107407.92
127 rdf:rest Nb08bb781495a49e0896d42d2c05d3de5
128 N8b47eec982fd4039991f0de2939e6246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Animals
130 rdf:type schema:DefinedTerm
131 N942f7b9ae8104e4581e65fbdcc4293a4 schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
132 rdf:type schema:Organization
133 Nb08bb781495a49e0896d42d2c05d3de5 rdf:first sg:person.01260332426.27
134 rdf:rest N0467a03db83345a38e4cacff53f8a08f
135 Nb2b57b9ba0914956ba6e534f1b04a051 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Receptors, G-Protein-Coupled
137 rdf:type schema:DefinedTerm
138 Nb9728a15e91848678d3ca2de4895f12f rdf:first sg:person.0777360014.47
139 rdf:rest N383d1588bed947708c7f572a5c58dbb2
140 Nbaea01b796994b3da4615d02278faa57 schema:name pubmed_id
141 schema:value 23563248
142 rdf:type schema:PropertyValue
143 Nd8102a4cf2b145b48f0f1ee3cc995e0e schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 Ndc05e21ca3ff415cb80f78450f72391d schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
146 rdf:type schema:Organization
147 Ndda38637954947ef80a6399c55ac8e4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 Ndf5f32c38c4e4f83acf6143659eacf22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Male
152 rdf:type schema:DefinedTerm
153 Ne1797302e0a74772aeb024d1904e5aaf schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
154 rdf:type schema:Organization
155 Ne2ee984afa2440789981bdfecd53d7a0 rdf:first sg:person.0660241732.86
156 rdf:rest Nf884e045b62c4c3685b3af9d333abb67
157 Nee076f148246417e86e5dda7628dcb2d schema:name Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
158 rdf:type schema:Organization
159 Nef9bd58d6db044e286fa178cb096caf7 rdf:first sg:person.0661622357.30
160 rdf:rest N3645c49e92a14a90b8231e1b04e069d8
161 Nf088dfaca4f0411fbabd3985e86f97be rdf:first sg:person.01277261021.51
162 rdf:rest N50042b6407564b72931aebdaf7791876
163 Nf2f10053ddfc4b30b22a3cdeba338572 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Obesity
165 rdf:type schema:DefinedTerm
166 Nf884e045b62c4c3685b3af9d333abb67 rdf:first sg:person.01302451207.28
167 rdf:rest Nb9728a15e91848678d3ca2de4895f12f
168 Nfba2cded94ad49c482019453da8ef663 schema:name dimensions_id
169 schema:value pub.1078713510
170 rdf:type schema:PropertyValue
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
175 schema:name Neurosciences
176 rdf:type schema:DefinedTerm
177 sg:grant.5147138 http://pending.schema.org/fundedItem sg:pub.10.3275/8929
178 rdf:type schema:MonetaryGrant
179 sg:journal.1088396 schema:issn 0391-4097
180 1720-8386
181 schema:name Journal of Endocrinological Investigation
182 rdf:type schema:Periodical
183 sg:person.01120107407.92 schema:affiliation N2f9c8bcbabd94ce4ae788ea5084195aa
184 schema:familyName Galli
185 schema:givenName G.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120107407.92
187 rdf:type schema:Person
188 sg:person.01171104613.28 schema:affiliation Ndc05e21ca3ff415cb80f78450f72391d
189 schema:familyName Ceccarini
190 schema:givenName G.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171104613.28
192 rdf:type schema:Person
193 sg:person.01226525757.06 schema:affiliation N019049a35c404c40981d572bf6f6e75a
194 schema:familyName Santini
195 schema:givenName F.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226525757.06
197 rdf:type schema:Person
198 sg:person.01260332426.27 schema:affiliation N2092c52cd7b64909a43b69db6b7d8a8c
199 schema:familyName Scartabelli
200 schema:givenName G.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260332426.27
202 rdf:type schema:Person
203 sg:person.01277261021.51 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
204 schema:familyName Marchi
205 schema:givenName M.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277261021.51
207 rdf:type schema:Person
208 sg:person.01302451207.28 schema:affiliation N4523cb996b8142dabfaf844970de7207
209 schema:familyName Fierabracci
210 schema:givenName P.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302451207.28
212 rdf:type schema:Person
213 sg:person.01344402654.02 schema:affiliation N942f7b9ae8104e4581e65fbdcc4293a4
214 schema:familyName Pinchera
215 schema:givenName A.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344402654.02
217 rdf:type schema:Person
218 sg:person.0622461715.77 schema:affiliation Nee076f148246417e86e5dda7628dcb2d
219 schema:familyName Tamberi
220 schema:givenName A.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622461715.77
222 rdf:type schema:Person
223 sg:person.0631021407.67 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
224 schema:familyName Maffei
225 schema:givenName M.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631021407.67
227 rdf:type schema:Person
228 sg:person.0660241732.86 schema:affiliation N7da16b37e2f14ab7a1bc6fc69bfb6e75
229 schema:familyName Latrofa
230 schema:givenName F.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660241732.86
232 rdf:type schema:Person
233 sg:person.0661622357.30 schema:affiliation N4a7423cc97374c25bfda4516d891f3a9
234 schema:familyName Pelosini
235 schema:givenName C.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661622357.30
237 rdf:type schema:Person
238 sg:person.0722053123.04 schema:affiliation Ne1797302e0a74772aeb024d1904e5aaf
239 schema:familyName Marsili
240 schema:givenName A.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722053123.04
242 rdf:type schema:Person
243 sg:person.0777360014.47 schema:affiliation N154faf6de557449abaf1161874f25e20
244 schema:familyName Vitti
245 schema:givenName P.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777360014.47
247 rdf:type schema:Person
248 sg:pub.10.1007/s10038-005-0238-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023389969
249 https://doi.org/10.1007/s10038-005-0238-8
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1006/geno.1995.1109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004298436
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0065-2423(09)48004-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024669948
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1073/pnas.0837789100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031145550
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1073/pnas.1334189100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042243432
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1074/jbc.m205337200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026976338
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1074/jbc.m206396200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000466060
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1079/bjn20041143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039932642
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/hmg/ddl215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049696141
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/nar/gkj518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042952078
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1210/er.2006-0040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285877
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1210/jc.2008-1595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064290899
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1210/jc.2010-2515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292534
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1210/jc.85.3.1001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064301280
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1371/journal.pgen.0020188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016317418
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1371/journal.pone.0016972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026097230
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1530/eje-08-0734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023360961
282 rdf:type schema:CreativeWork
283 https://www.grid.ac/institutes/grid.144189.1 schema:alternateName Azienda Ospedaliera Universitaria Pisana
284 schema:name Dulbecco Telethon Institute, Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy
285 IFC CNR, Pisa, Italy
286 Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...