Detection of JC virus DNA in peripheral blood cell subpopulations of HIV-1-infected individuals. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-01

AUTHORS

I J Koralnik, J E Schmitz, M A Lifton, M A Forman, N L Letvin

ABSTRACT

While it has been suggested that JC virus (JCV) migrates in B-lymphocytes from the kidney to the central nervous system where it initiates demyelination, this phase of JCV pathogenesis has not been systematically explored. To determine the peripheral blood cell subpopulation(s) infected with JCV, monocytes, granulocytes, and T and B lymphocytes from HIV-1-infected individuals and uninfected controls were purified by flow cytometry. JCV DNA could be detected by PCR amplification in all of these cell subpopulations. This finding suggests that JCV lacks specificity in its interaction with leukocytes. More... »

PAGES

430-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.3109/13550289909029484

DOI

http://dx.doi.org/10.3109/13550289909029484

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1070986140

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10463865


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