Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09

AUTHORS

Ned Sacktor, Richard L Skolasky, Christopher Cox, Ola Selnes, James T Becker, Bruce Cohen, Eileen Martin, Eric N Miller, Multicenter AIDS Cohort Study (MACS)

ABSTRACT

Older human immunodeficiency virus-seropositive (HIV+) individuals (greater than age 50 years) are twice as likely to develop HIV dementia compared to younger HIV+ individuals. The objective of this study was to examine the impact of both age and serostatus on longitudinal changes in psychomotor speed/executive functioning performance among HIV+ and HIV− individuals. Four hundred and seventy-seven HIV+ and 799 HIV− individuals from the Multicenter AIDS Cohort Study (MACS) were subdivided into three age groups: (1) <40 years, (2) 40-50 years, and (3) >50 years. Psychomotor speed/executive functioning test performance was measured by the Symbol Digit Modalities Test (SDMT) and the Trail Making (TM) Test Parts A and B. Changes in performance were compared among the three age groups for both HIV+ and HIV− individuals. Among HIV+ individuals, on the TM Test Part B the younger group demonstrated improvement in performance over time (P = .007). The older and middle age groups demonstrated decline in performance over time (P = .041 and .030). The older group had a significantly different trajectory relative to the younger group (P = .046). Among the HIV− individuals, there was no effect of age on longitudinal performance. In conclusion, older HIV+ individuals show greater decline over time than younger HIV+ individuals on the TM Test Part B. Our results suggest that both HIV serostatus and age together may impact longitudinal performance on this test. Mild neurocognitive changes over time among older HIV+ individuals are likely to reflect age associated pathophysiological mechanisms including cerebrovascular risk factors. More... »

PAGES

335-341

Identifiers

URI

http://scigraph.springernature.com/pub.10.3109/13550284.2010.504249

DOI

http://dx.doi.org/10.3109/13550284.2010.504249

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017353783

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20726699


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AIDS Dementia Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-HIV Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiretroviral Therapy, Highly Active", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Seronegativity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Seropositivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multicenter Studies as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Psychomotor Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Task Performance and Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Bayview Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411940.9", 
          "name": [
            "Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, B Building, Room 123, 21224, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sacktor", 
        "givenName": "Ned", 
        "id": "sg:person.01064501570.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064501570.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Skolasky", 
        "givenName": "Richard L", 
        "id": "sg:person.014771636437.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014771636437.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cox", 
        "givenName": "Christopher", 
        "id": "sg:person.01064572446.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064572446.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Bayview Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411940.9", 
          "name": [
            "Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, B Building, Room 123, 21224, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selnes", 
        "givenName": "Ola", 
        "id": "sg:person.01052374040.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052374040.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412689.0", 
          "name": [
            "Departments of Psychiatry and Neurology and Psychology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Becker", 
        "givenName": "James T", 
        "id": "sg:person.013325351152.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013325351152.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwestern University", 
          "id": "https://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Neurology, Northwestern University, Chicago, Illinois, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cohen", 
        "givenName": "Bruce", 
        "id": "sg:person.012004063162.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012004063162.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Illinois at Chicago", 
          "id": "https://www.grid.ac/institutes/grid.185648.6", 
          "name": [
            "Department of Psychiatry, University of Illinois, Chicago, Illinois, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martin", 
        "givenName": "Eileen", 
        "id": "sg:person.01066336116.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066336116.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "The Semel Institute for Neuroscience, University of California, Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miller", 
        "givenName": "Eric N", 
        "id": "sg:person.014757252032.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014757252032.04"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Multicenter AIDS Cohort Study (MACS)", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1146/annurev.ps.46.020195.001553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014748892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1993.00540030016007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018839577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199907090-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021717061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199907090-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021717061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0033-295x.103.3.403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024912728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-4356(01)00445-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025014109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/13550280701258423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026305606", 
          "https://doi.org/10.1080/13550280701258423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1207/s15324826an1002_03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035915097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awh553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041835815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awh553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041835815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/126.2.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059380798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.162.8.1461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063496797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000134665.58343.8d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000134665.58343.8d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000134665.58343.8d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000149641.55751.2e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000149641.55751.2e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000149641.55751.2e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000158283.28251.3c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000158283.28251.3c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000158283.28251.3c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000277520.94788.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000277520.94788.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000277520.94788.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000287431.88658.8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000287431.88658.8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000287431.88658.8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181bd10e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181bd10e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181bd10e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181bd10e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.3109/13550289609146906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070985957", 
          "https://doi.org/10.3109/13550289609146906"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-09", 
    "datePublishedReg": "2010-09-01", 
    "description": "Older human immunodeficiency virus-seropositive (HIV+) individuals (greater than age 50 years) are twice as likely to develop HIV dementia compared to younger HIV+ individuals. The objective of this study was to examine the impact of both age and serostatus on longitudinal changes in psychomotor speed/executive functioning performance among HIV+ and HIV\u2212 individuals. Four hundred and seventy-seven HIV+ and 799 HIV\u2212 individuals from the Multicenter AIDS Cohort Study (MACS) were subdivided into three age groups: (1) <40 years, (2) 40-50 years, and (3) >50 years. Psychomotor speed/executive functioning test performance was measured by the Symbol Digit Modalities Test (SDMT) and the Trail Making (TM) Test Parts A and B. Changes in performance were compared among the three age groups for both HIV+ and HIV\u2212 individuals. Among HIV+ individuals, on the TM Test Part B the younger group demonstrated improvement in performance over time (P = .007). The older and middle age groups demonstrated decline in performance over time (P = .041 and .030). The older group had a significantly different trajectory relative to the younger group (P = .046). Among the HIV\u2212 individuals, there was no effect of age on longitudinal performance. In conclusion, older HIV+ individuals show greater decline over time than younger HIV+ individuals on the TM Test Part B. Our results suggest that both HIV serostatus and age together may impact longitudinal performance on this test. Mild neurocognitive changes over time among older HIV+ individuals are likely to reflect age associated pathophysiological mechanisms including cerebrovascular risk factors.", 
    "genre": "research_article", 
    "id": "sg:pub.10.3109/13550284.2010.504249", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2687333", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2687335", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2424013", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2687337", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2687334", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2687336", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2550746", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2551491", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437332", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2423971", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1114176", 
        "issn": [
          "1355-0284", 
          "1538-2443"
        ], 
        "name": "Journal of NeuroVirology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus", 
    "pagination": "335-341", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "52ae3a20c64aabb36336713be8edb6e03c855a7d712d6ad3dbb5eb0acdf25c51"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20726699"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9508123"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.3109/13550284.2010.504249"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017353783"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.3109/13550284.2010.504249", 
      "https://app.dimensions.ai/details/publication/pub.1017353783"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.3109/13550284.2010.504249"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.3109/13550284.2010.504249'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.3109/13550284.2010.504249'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.3109/13550284.2010.504249'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.3109/13550284.2010.504249'


 

This table displays all metadata directly associated to this object as RDF triples.

271 TRIPLES      21 PREDICATES      61 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.3109/13550284.2010.504249 schema:about N00291b829d8841b29381bc0bf019f2e0
2 N09f533061a0140e483f55a4cf88b47d5
3 N43f70084f750482b978fc5187f244e56
4 N5a4b8d44f6e34e3d8840b0d1f43dc8aa
5 N6af88d0878d14a8385e495b51c77c9b4
6 N838a85cd61d248cf922643fb45194bd7
7 N8508d8a0190c42ccb6a6543e83531999
8 N964bd25f16fa4693b7230e0adb231b20
9 Na11d870c0dde4d7e83fdfde2a0971f41
10 Na855b75dc8c94614b76c11f811268ef0
11 Nc10f1c49fad64fcc8c1850f4b1b41587
12 Nd2d143364fdb4366a8261d0d57d0a211
13 Nd8b9ae7ad96d4602b0def17219c43fdc
14 Nda299856b08d41b396d40c07d0193b28
15 Nf163733bfe2c40249e5fb6c1dbd8c77f
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N5248d799f8f6448bab2aeaf92008d32c
19 schema:citation sg:pub.10.1080/13550280701258423
20 sg:pub.10.3109/13550289609146906
21 https://doi.org/10.1001/archneur.1993.00540030016007
22 https://doi.org/10.1016/s0895-4356(01)00445-0
23 https://doi.org/10.1037/0033-295x.103.3.403
24 https://doi.org/10.1093/aje/126.2.310
25 https://doi.org/10.1093/brain/awh553
26 https://doi.org/10.1097/00002030-199907090-00015
27 https://doi.org/10.1146/annurev.ps.46.020195.001553
28 https://doi.org/10.1176/appi.ajp.162.8.1461
29 https://doi.org/10.1207/s15324826an1002_03
30 https://doi.org/10.1212/01.wnl.0000134665.58343.8d
31 https://doi.org/10.1212/01.wnl.0000149641.55751.2e
32 https://doi.org/10.1212/01.wnl.0000158283.28251.3c
33 https://doi.org/10.1212/01.wnl.0000277520.94788.82
34 https://doi.org/10.1212/01.wnl.0000287431.88658.8b
35 https://doi.org/10.1212/wnl.0b013e3181bd10e7
36 schema:datePublished 2010-09
37 schema:datePublishedReg 2010-09-01
38 schema:description Older human immunodeficiency virus-seropositive (HIV+) individuals (greater than age 50 years) are twice as likely to develop HIV dementia compared to younger HIV+ individuals. The objective of this study was to examine the impact of both age and serostatus on longitudinal changes in psychomotor speed/executive functioning performance among HIV+ and HIV− individuals. Four hundred and seventy-seven HIV+ and 799 HIV− individuals from the Multicenter AIDS Cohort Study (MACS) were subdivided into three age groups: (1) <40 years, (2) 40-50 years, and (3) >50 years. Psychomotor speed/executive functioning test performance was measured by the Symbol Digit Modalities Test (SDMT) and the Trail Making (TM) Test Parts A and B. Changes in performance were compared among the three age groups for both HIV+ and HIV− individuals. Among HIV+ individuals, on the TM Test Part B the younger group demonstrated improvement in performance over time (P = .007). The older and middle age groups demonstrated decline in performance over time (P = .041 and .030). The older group had a significantly different trajectory relative to the younger group (P = .046). Among the HIV− individuals, there was no effect of age on longitudinal performance. In conclusion, older HIV+ individuals show greater decline over time than younger HIV+ individuals on the TM Test Part B. Our results suggest that both HIV serostatus and age together may impact longitudinal performance on this test. Mild neurocognitive changes over time among older HIV+ individuals are likely to reflect age associated pathophysiological mechanisms including cerebrovascular risk factors.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N70e2c8fc64b64a979e0dfb6bdf606413
43 Nb71c8308c2af4a01b0d1729a92055352
44 sg:journal.1114176
45 schema:name Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus
46 schema:pagination 335-341
47 schema:productId N40c6fce2a4104f1d90f22e563e5b1fc5
48 N4c57f6d039224627a37f16bfd411959e
49 N5fc37ac60b764b139fd55d44ea83d2a3
50 N64fd116f37444c43b0a9cc1534158116
51 N797e6d96366844bbb7b30823c1bb8570
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017353783
53 https://doi.org/10.3109/13550284.2010.504249
54 schema:sdDatePublished 2019-04-10T18:18
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher N064188b5e2854ecba27b9847f4014426
57 schema:url http://link.springer.com/10.3109/13550284.2010.504249
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N00291b829d8841b29381bc0bf019f2e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Cohort Studies
63 rdf:type schema:DefinedTerm
64 N064188b5e2854ecba27b9847f4014426 schema:name Springer Nature - SN SciGraph project
65 rdf:type schema:Organization
66 N09f533061a0140e483f55a4cf88b47d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Anti-HIV Agents
68 rdf:type schema:DefinedTerm
69 N17d58645717447cb85ffe71432ed5bb3 rdf:first sg:person.014757252032.04
70 rdf:rest Nba265e365e5a462db43da8f0b0c2d1b1
71 N40c6fce2a4104f1d90f22e563e5b1fc5 schema:name dimensions_id
72 schema:value pub.1017353783
73 rdf:type schema:PropertyValue
74 N43f70084f750482b978fc5187f244e56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Multicenter Studies as Topic
76 rdf:type schema:DefinedTerm
77 N463859418acc47c2af8e4c052171c93c rdf:first sg:person.01064572446.45
78 rdf:rest Na7cc45eaa7ec493dab1645ccd0369bb8
79 N4c57f6d039224627a37f16bfd411959e schema:name doi
80 schema:value 10.3109/13550284.2010.504249
81 rdf:type schema:PropertyValue
82 N5248d799f8f6448bab2aeaf92008d32c rdf:first sg:person.01064501570.98
83 rdf:rest N6e1835c88fff4843a3e28d28fade1624
84 N5a4b8d44f6e34e3d8840b0d1f43dc8aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Psychomotor Disorders
86 rdf:type schema:DefinedTerm
87 N5fc37ac60b764b139fd55d44ea83d2a3 schema:name pubmed_id
88 schema:value 20726699
89 rdf:type schema:PropertyValue
90 N630447ca5e4e4831a3b41a98ab503b41 rdf:first sg:person.012004063162.55
91 rdf:rest Nf4be60855db74b34b508807793d3d5e9
92 N64fd116f37444c43b0a9cc1534158116 schema:name readcube_id
93 schema:value 52ae3a20c64aabb36336713be8edb6e03c855a7d712d6ad3dbb5eb0acdf25c51
94 rdf:type schema:PropertyValue
95 N6af88d0878d14a8385e495b51c77c9b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name HIV Seronegativity
97 rdf:type schema:DefinedTerm
98 N6e1835c88fff4843a3e28d28fade1624 rdf:first sg:person.014771636437.98
99 rdf:rest N463859418acc47c2af8e4c052171c93c
100 N70e2c8fc64b64a979e0dfb6bdf606413 schema:volumeNumber 16
101 rdf:type schema:PublicationVolume
102 N797e6d96366844bbb7b30823c1bb8570 schema:name nlm_unique_id
103 schema:value 9508123
104 rdf:type schema:PropertyValue
105 N838a85cd61d248cf922643fb45194bd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Middle Aged
107 rdf:type schema:DefinedTerm
108 N8508d8a0190c42ccb6a6543e83531999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Age Factors
110 rdf:type schema:DefinedTerm
111 N964bd25f16fa4693b7230e0adb231b20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Risk Factors
113 rdf:type schema:DefinedTerm
114 Na11d870c0dde4d7e83fdfde2a0971f41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name United States
116 rdf:type schema:DefinedTerm
117 Na7cc45eaa7ec493dab1645ccd0369bb8 rdf:first sg:person.01052374040.09
118 rdf:rest Nf5e2dd1a79ca4fe5a694c083c5bd9855
119 Na855b75dc8c94614b76c11f811268ef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Adult
121 rdf:type schema:DefinedTerm
122 Nb71c8308c2af4a01b0d1729a92055352 schema:issueNumber 5
123 rdf:type schema:PublicationIssue
124 Nba265e365e5a462db43da8f0b0c2d1b1 rdf:first Nf63ba6ff547843dca8b7a1c476881c92
125 rdf:rest rdf:nil
126 Nc10f1c49fad64fcc8c1850f4b1b41587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name AIDS Dementia Complex
128 rdf:type schema:DefinedTerm
129 Nd2d143364fdb4366a8261d0d57d0a211 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Humans
131 rdf:type schema:DefinedTerm
132 Nd8b9ae7ad96d4602b0def17219c43fdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Antiretroviral Therapy, Highly Active
134 rdf:type schema:DefinedTerm
135 Nda299856b08d41b396d40c07d0193b28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name HIV Seropositivity
137 rdf:type schema:DefinedTerm
138 Nf163733bfe2c40249e5fb6c1dbd8c77f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Task Performance and Analysis
140 rdf:type schema:DefinedTerm
141 Nf4be60855db74b34b508807793d3d5e9 rdf:first sg:person.01066336116.91
142 rdf:rest N17d58645717447cb85ffe71432ed5bb3
143 Nf5e2dd1a79ca4fe5a694c083c5bd9855 rdf:first sg:person.013325351152.78
144 rdf:rest N630447ca5e4e4831a3b41a98ab503b41
145 Nf63ba6ff547843dca8b7a1c476881c92 schema:familyName Multicenter AIDS Cohort Study (MACS)
146 rdf:type schema:Person
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
151 schema:name Clinical Sciences
152 rdf:type schema:DefinedTerm
153 sg:grant.2423971 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
154 rdf:type schema:MonetaryGrant
155 sg:grant.2424013 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
156 rdf:type schema:MonetaryGrant
157 sg:grant.2437332 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
158 rdf:type schema:MonetaryGrant
159 sg:grant.2550746 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
160 rdf:type schema:MonetaryGrant
161 sg:grant.2551491 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
162 rdf:type schema:MonetaryGrant
163 sg:grant.2687333 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
164 rdf:type schema:MonetaryGrant
165 sg:grant.2687334 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
166 rdf:type schema:MonetaryGrant
167 sg:grant.2687335 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
168 rdf:type schema:MonetaryGrant
169 sg:grant.2687336 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
170 rdf:type schema:MonetaryGrant
171 sg:grant.2687337 http://pending.schema.org/fundedItem sg:pub.10.3109/13550284.2010.504249
172 rdf:type schema:MonetaryGrant
173 sg:journal.1114176 schema:issn 1355-0284
174 1538-2443
175 schema:name Journal of NeuroVirology
176 rdf:type schema:Periodical
177 sg:person.01052374040.09 schema:affiliation https://www.grid.ac/institutes/grid.411940.9
178 schema:familyName Selnes
179 schema:givenName Ola
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052374040.09
181 rdf:type schema:Person
182 sg:person.01064501570.98 schema:affiliation https://www.grid.ac/institutes/grid.411940.9
183 schema:familyName Sacktor
184 schema:givenName Ned
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064501570.98
186 rdf:type schema:Person
187 sg:person.01064572446.45 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
188 schema:familyName Cox
189 schema:givenName Christopher
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064572446.45
191 rdf:type schema:Person
192 sg:person.01066336116.91 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
193 schema:familyName Martin
194 schema:givenName Eileen
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066336116.91
196 rdf:type schema:Person
197 sg:person.012004063162.55 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
198 schema:familyName Cohen
199 schema:givenName Bruce
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012004063162.55
201 rdf:type schema:Person
202 sg:person.013325351152.78 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
203 schema:familyName Becker
204 schema:givenName James T
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013325351152.78
206 rdf:type schema:Person
207 sg:person.014757252032.04 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
208 schema:familyName Miller
209 schema:givenName Eric N
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014757252032.04
211 rdf:type schema:Person
212 sg:person.014771636437.98 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
213 schema:familyName Skolasky
214 schema:givenName Richard L
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014771636437.98
216 rdf:type schema:Person
217 sg:pub.10.1080/13550280701258423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026305606
218 https://doi.org/10.1080/13550280701258423
219 rdf:type schema:CreativeWork
220 sg:pub.10.3109/13550289609146906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070985957
221 https://doi.org/10.3109/13550289609146906
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1001/archneur.1993.00540030016007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018839577
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0895-4356(01)00445-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025014109
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1037/0033-295x.103.3.403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024912728
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/aje/126.2.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059380798
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/brain/awh553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041835815
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1097/00002030-199907090-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021717061
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1146/annurev.ps.46.020195.001553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014748892
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1176/appi.ajp.162.8.1461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063496797
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1207/s15324826an1002_03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035915097
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1212/01.wnl.0000134665.58343.8d schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346253
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1212/01.wnl.0000149641.55751.2e schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346736
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1212/01.wnl.0000158283.28251.3c schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346984
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1212/01.wnl.0000277520.94788.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347214
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1212/01.wnl.0000287431.88658.8b schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347220
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1212/wnl.0b013e3181bd10e7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354685
252 rdf:type schema:CreativeWork
253 https://www.grid.ac/institutes/grid.16753.36 schema:alternateName Northwestern University
254 schema:name Department of Neurology, Northwestern University, Chicago, Illinois, USA
255 rdf:type schema:Organization
256 https://www.grid.ac/institutes/grid.185648.6 schema:alternateName University of Illinois at Chicago
257 schema:name Department of Psychiatry, University of Illinois, Chicago, Illinois, USA
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
260 schema:name The Semel Institute for Neuroscience, University of California, Los Angeles, California, USA
261 rdf:type schema:Organization
262 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
263 schema:name Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
264 Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, USA
265 rdf:type schema:Organization
266 https://www.grid.ac/institutes/grid.411940.9 schema:alternateName Johns Hopkins Bayview Medical Center
267 schema:name Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, B Building, Room 123, 21224, Baltimore, MD, USA
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.412689.0 schema:alternateName University of Pittsburgh Medical Center
270 schema:name Departments of Psychiatry and Neurology and Psychology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
271 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...