Evidence for developmental dopaminergic alterations in the human immunodeficiency virus-1 transgenic rat View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-03

AUTHORS

Katy M. Webb, Michael Y. Aksenov, Charles F. Mactutus, Rosemarie M. Booze

ABSTRACT

Neurologic impairments associated with human immunodeficiency virus (HIV) infection in pediatric patients may affect quality of life, and can develop despite antiretroviral therapy (ART). Behavioral changes observed in clinical studies of HIV-infected children suggest alterations in dopaminergic neurotransmission. Findings from our model of choice, the HIV-1 transgenic rat, reveal a significant increase in phosphorylated tyrosine hydroxylase protein expression and a decrease in dopamine transporter mRNA, without changes in tyrosine hydroxylase (TH) or dopamine transporter (DAT) protein or in more general markers of protein and gene expression levels in the HIV-1 transgenic rat midbrain. Thus these findings suggest selective vulnerability of the dopamine system in developing brains to HIV-1 infection. More... »

PAGES

168-173

Identifiers

URI

http://scigraph.springernature.com/pub.10.3109/13550281003690177

DOI

http://dx.doi.org/10.3109/13550281003690177

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1070985848

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20337512


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