Ontology type: schema:ScholarlyArticle
2000-01
AUTHORS ABSTRACTWe investigated the role played by inflammation in acute encephalitis following infection with a neurotropic virus by comparing the disease caused by the CVS strain of rabies virus in C57BL/6 and mice deficient for the p55 Kd TNF-alpha receptor (p55TNFR-/-). Morbidity (weight loss and paralysis) and mortality of infected mice were associated with viral propagation, cytokine (IL-6, IL-10, TNF-alpha and IFN-gamma) production, induction of apoptosis and infiltration of inflammatory cells. Mortality occurred later in p55TNFR-/- (than in C57BL/6 mice. In contrast, morbidity and the number of cells undergoing apoptosis were similar in C57BL/6 and p55TNFR-/- mice.) This suggests that morbidity and mortality are independently regulated and that the death of the animal was not due to CNS apoptosis. Delayed mortality correlated with: a reduction in viral load on day 9 p.i., an increase in IFN-gamma and IL-10 concentrations and a reduction in inflammatory cell infiltration in the CNS. Thus, these data indicate that CVS infection elicits an inflammatory response within the CNS and suggest that cytokines signaling via the p55 Kd TNF-alpha receptor is deleterious for the survival of the host. These results strongly suggest that, the modulation of TNF-alpha and upregulation of IFN-gamma would be a powerful anti-virus strategy in cases of viral encephalitis. More... »
PAGES507-18
http://scigraph.springernature.com/pub.10.3109/13550280009091951
DOIhttp://dx.doi.org/10.3109/13550280009091951
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1070985838
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11175323
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antigens, CD",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Apoptosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytokines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Encephalitis, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fas Ligand Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interferon-gamma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Glycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Knockout",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Mutant Strains",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Paralysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rabies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rabies virus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Tumor Necrosis Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Tumor Necrosis Factor, Type I",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spinal Cord",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Necrosis Factor-alpha",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Virus Replication",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Weight Loss",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Unit\u00e9 de Neurovirologie et R\u00e9g\u00e9n\u00e9ration du Syst\u00e8me Nerveux, D\u00e9partement de Virologie, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.",
"id": "http://www.grid.ac/institutes/grid.428999.7",
"name": [
"Unit\u00e9 de Neurovirologie et R\u00e9g\u00e9n\u00e9ration du Syst\u00e8me Nerveux, D\u00e9partement de Virologie, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France."
],
"type": "Organization"
},
"familyName": "Camelo",
"givenName": "S",
"id": "sg:person.01337534012.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337534012.31"
],
"type": "Person"
},
{
"familyName": "Lafage",
"givenName": "M",
"id": "sg:person.0713260453.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713260453.81"
],
"type": "Person"
},
{
"familyName": "Lafon",
"givenName": "M",
"id": "sg:person.0761373653.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761373653.61"
],
"type": "Person"
}
],
"datePublished": "2000-01",
"datePublishedReg": "2000-01-01",
"description": "We investigated the role played by inflammation in acute encephalitis following infection with a neurotropic virus by comparing the disease caused by the CVS strain of rabies virus in C57BL/6 and mice deficient for the p55 Kd TNF-alpha receptor (p55TNFR-/-). Morbidity (weight loss and paralysis) and mortality of infected mice were associated with viral propagation, cytokine (IL-6, IL-10, TNF-alpha and IFN-gamma) production, induction of apoptosis and infiltration of inflammatory cells. Mortality occurred later in p55TNFR-/- (than in C57BL/6 mice. In contrast, morbidity and the number of cells undergoing apoptosis were similar in C57BL/6 and p55TNFR-/- mice.) This suggests that morbidity and mortality are independently regulated and that the death of the animal was not due to CNS apoptosis. Delayed mortality correlated with: a reduction in viral load on day 9 p.i., an increase in IFN-gamma and IL-10 concentrations and a reduction in inflammatory cell infiltration in the CNS. Thus, these data indicate that CVS infection elicits an inflammatory response within the CNS and suggest that cytokines signaling via the p55 Kd TNF-alpha receptor is deleterious for the survival of the host. These results strongly suggest that, the modulation of TNF-alpha and upregulation of IFN-gamma would be a powerful anti-virus strategy in cases of viral encephalitis.",
"genre": "article",
"id": "sg:pub.10.3109/13550280009091951",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1114176",
"issn": [
"1355-0284",
"1538-2443"
],
"name": "Journal of NeuroVirology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "6"
}
],
"keywords": [
"TNF-alpha receptors",
"IFN-gamma",
"IL-10 concentrations",
"inflammatory cell infiltration",
"day 9 p.",
"CV infection",
"acute encephalitis",
"viral load",
"viral encephalitis",
"infected mice",
"neurotropic viruses",
"cytokine production",
"inflammatory cells",
"cell infiltration",
"TNF-alpha",
"inflammatory response",
"CVS strain",
"CNS apoptosis",
"induction of apoptosis",
"mortality",
"rabies virus",
"receptors",
"morbidity",
"viral propagation",
"encephalitis",
"infection",
"mice",
"survival",
"infiltration",
"anti-virus strategies",
"virus",
"apoptosis",
"inflammation",
"cytokines",
"C57BL/6",
"disease",
"p55TNFR",
"upregulation",
"death",
"CN",
"rabies",
"induction",
"animals",
"reduction",
"cells",
"response",
"modulation",
"p.",
"absence",
"cases",
"role",
"increase",
"strains",
"host",
"concentration",
"data",
"strategies",
"production",
"results",
"load",
"propagation"
],
"name": "Absence of the p55 Kd TNF-alpha receptor promotes survival in rabies virus acute encephalitis.",
"pagination": "507-18",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1070985838"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.3109/13550280009091951"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"11175323"
]
}
],
"sameAs": [
"https://doi.org/10.3109/13550280009091951",
"https://app.dimensions.ai/details/publication/pub.1070985838"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T09:49",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_343.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.3109/13550280009091951"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.3109/13550280009091951'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.3109/13550280009091951'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.3109/13550280009091951'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.3109/13550280009091951'
This table displays all metadata directly associated to this object as RDF triples.
227 TRIPLES
21 PREDICATES
111 URIs
103 LITERALS
30 BLANK NODES