Hypothesis on the Origin of Viruses from Transposons View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10

AUTHORS

R. N. Mustafin

ABSTRACT

In this review, the role of transposons in the origin of viruses, losing the traits of their evolutionary precursors due to their high mutability, is considered. However, there are a number of common properties of viruses and transposons suggesting their phylogenetic relationship, including the ability to integrate into the host genome, specific activation in certain tissues, high degree of mutability, the existence of virophages propagating only in the presence of another virus (which is similar to non-autonomous transposons, for which the expression products of autonomous ones are required). Ideas about the emergence of viruses from transposons in evolution are discussed. The genomic elements exhibiting a dual nature of existence as mobile genetic elements and viruses are found: polintons, Tlr elements, and PLV viruses. It is assumed that a horizontal transfer (HT) of transposons, during the natural selection of which the elements possessing the virulence properties are preserved (while the genes required for the integration can mutate), is a key event required for turning into viruses. The horizontal transposon transfer, which is common in all representatives of living organisms, is accompanied by their variability required for the acquisition of new adaptive traits. In the course of evolution, the mechanisms of protection against viruses and transposons, including RNA interference, DNA methylation, and histone modification, began to be used to control the operation of the genomes, providing intercellular interactions; this explains the emergence of multicellular organisms. In the evolution of eukaryotes, the transposons have been used successfully for transformations of regulatory gene networks, as well as possible sources of new genes encoding both proteins and non-coding RNA, the fragmentary translation of which can produce short functional peptides. Thus, the products of transposon transcription and translation are the most important sources of evolutionary transformations; these mechanisms could be the basis for the evolution of viruses and the emergence of the fundamental properties of living organisms when they appear. More... »

PAGES

223-232

References to SciGraph publications

  • 2013-12. A mobile genetic element with unknown function found in distantly related viruses in VIROLOGY JOURNAL
  • 2015-12. ITIS, a bioinformatics tool for accurate identification of transposon insertion sites using next-generation sequencing data in BMC BIOINFORMATICS
  • 2009-12. Network dynamics of eukaryotic LTR retroelements beyond phylogenetic trees in BIOLOGY DIRECT
  • 2007-12. A unified classification system for eukaryotic transposable elements in NATURE REVIEWS GENETICS
  • 2014-01. Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes in GENOME BIOLOGY
  • 2015-12. DNA transposons have colonized the genome of the giant virus Pandoravirus salinus in BMC BIOLOGY
  • 2013-12. Human Cytomegalovirus (HCMV) induces Human Endogenous Retrovirus (HERV) transcription in RETROVIROLOGY
  • 2015-02. Polintons: a hotbed of eukaryotic virus, transposon and plasmid evolution in NATURE REVIEWS MICROBIOLOGY
  • 2014-03. Emerging evidence for functional peptides encoded by short open reading frames in NATURE REVIEWS GENETICS
  • 2015-08. terMITEs: miniature inverted-repeat transposable elements (MITEs) in the termite genome (Blattodea: Termitoidae) in MOLECULAR GENETICS AND GENOMICS
  • 2012-08. Functional characterization of an active Rag-like transposase in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2015-12. A novel group of diverse Polinton-like viruses discovered by metagenome analysis in BMC BIOLOGY
  • 2011-04. Transfer of a chromosomal Maverick to endogenous bracovirus in a parasitoid wasp in GENETICA
  • 2013-12. Horizontal transfer of OC1 transposons in the Tasmanian devil in BMC GENOMICS
  • 2008-05. Transposable elements and the evolution of regulatory networks in NATURE REVIEWS GENETICS
  • 2015-12. A family of transposable elements co-opted into developmental enhancers in the mouse neocortex in NATURE COMMUNICATIONS
  • 2017-11-15. The functions and unique features of long intergenic non-coding RNA in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-12. Conservation of major and minor jelly-roll capsid proteins in Polinton (Maverick) transposons suggests that they are bona fide viruses in BIOLOGY DIRECT
  • 2017-02. Regulatory activities of transposable elements: from conflicts to benefits in NATURE REVIEWS GENETICS
  • 2014. Determination of the Transforming Activities of Adenovirus Oncogenes in ADENOVIRUS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.3103/s0891416818040067

    DOI

    http://dx.doi.org/10.3103/s0891416818040067

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112469731


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Bashkir State University", 
              "id": "https://www.grid.ac/institutes/grid.77269.3d", 
              "name": [
                "Bashkir State Medical University, 450008, Ufa, Russia", 
                "Bashkir State University, 450076, Ufa, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mustafin", 
            "givenName": "R. N.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/978-1-62703-679-5_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000067141", 
              "https://doi.org/10.1007/978-1-62703-679-5_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/gbe/evu140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001892697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/gbe/evu112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002634126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0509720103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003606007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1116168109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004076082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/v7031238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006187831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2015.02.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006379629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00438-015-1010-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006964518", 
              "https://doi.org/10.1007/s00438-015-1010-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro3389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007677483", 
              "https://doi.org/10.1038/nrmicro3389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0114083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008499122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0114083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008499122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/gbe/evv049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010661404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.044560.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013276175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0806548105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013703484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1745-6150-9-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015316770", 
              "https://doi.org/10.1186/1745-6150-9-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-14-134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016802646", 
              "https://doi.org/10.1186/1471-2164-14-134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fpls.2016.01436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017405615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12915-015-0145-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018199349", 
              "https://doi.org/10.1186/s12915-015-0145-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12915-015-0145-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018199349", 
              "https://doi.org/10.1186/s12915-015-0145-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018653093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018701184", 
              "https://doi.org/10.1038/nrg3520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019708754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019935618", 
              "https://doi.org/10.1038/nsmb.2338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12915-015-0207-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021268326", 
              "https://doi.org/10.1186/s12915-015-0207-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/database/bav004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021384128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad4076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021434601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5808/gi.2014.12.4.261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022676779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0600833103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023435534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mib.2016.01.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026153362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.03523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028980661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.smim.2009.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031471979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7644", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032261677", 
              "https://doi.org/10.1038/ncomms7644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10709-011-9569-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032502601", 
              "https://doi.org/10.1007/s10709-011-9569-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.107.084491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033940524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.107.084491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033940524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg.2016.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034466564", 
              "https://doi.org/10.1038/nrg.2016.139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2222/jsv.61.25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034547987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1745-6150-4-41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034655595", 
              "https://doi.org/10.1186/1745-6150-4-41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.10565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034880122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.03653-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035317846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036005113", 
              "https://doi.org/10.1038/nrg2337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.8.2531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036087388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ympev.2014.05.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036373036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gki236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036540062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.18.9454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039283292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/embj.201488411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041744407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042102077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-4690-10-132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042422235", 
              "https://doi.org/10.1186/1742-4690-10-132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1743-422x-10-132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043037167", 
              "https://doi.org/10.1186/1743-422x-10-132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12859-015-0507-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044238183", 
              "https://doi.org/10.1186/s12859-015-0507-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12859-015-0507-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044238183", 
              "https://doi.org/10.1186/s12859-015-0507-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12859-015-0507-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044238183", 
              "https://doi.org/10.1186/s12859-015-0507-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1005279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046884688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2014-15-1-r6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047079213", 
              "https://doi.org/10.1186/gb-2014-15-1-r6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2015.01.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047892845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/nyas.12728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048533705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msv042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048917678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0509809103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049171285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btv132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049547692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1317811111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052895568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053647019", 
              "https://doi.org/10.1038/nrg2165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15476286.2015.1094601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058403040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.15.00920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060842238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1199412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062463045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v20.i33.11630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071371352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07536.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077299052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078393047", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.2001536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083840025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/gbe/evx122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090336650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090650952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/sciadv.aao2110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091975604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msx275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092359497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2017.104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092689395", 
              "https://doi.org/10.1038/nrm.2017.104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dci.2017.11.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092957265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/database/bax102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099890057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.12.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100318359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/thno.24677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103654410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/thno.24677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103654410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/9781555819217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109532691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/9781555819217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109532691"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-10", 
        "datePublishedReg": "2018-10-01", 
        "description": "In this review, the role of transposons in the origin of viruses, losing the traits of their evolutionary precursors due to their high mutability, is considered. However, there are a number of common properties of viruses and transposons suggesting their phylogenetic relationship, including the ability to integrate into the host genome, specific activation in certain tissues, high degree of mutability, the existence of virophages propagating only in the presence of another virus (which is similar to non-autonomous transposons, for which the expression products of autonomous ones are required). Ideas about the emergence of viruses from transposons in evolution are discussed. The genomic elements exhibiting a dual nature of existence as mobile genetic elements and viruses are found: polintons, Tlr elements, and PLV viruses. It is assumed that a horizontal transfer (HT) of transposons, during the natural selection of which the elements possessing the virulence properties are preserved (while the genes required for the integration can mutate), is a key event required for turning into viruses. The horizontal transposon transfer, which is common in all representatives of living organisms, is accompanied by their variability required for the acquisition of new adaptive traits. In the course of evolution, the mechanisms of protection against viruses and transposons, including RNA interference, DNA methylation, and histone modification, began to be used to control the operation of the genomes, providing intercellular interactions; this explains the emergence of multicellular organisms. In the evolution of eukaryotes, the transposons have been used successfully for transformations of regulatory gene networks, as well as possible sources of new genes encoding both proteins and non-coding RNA, the fragmentary translation of which can produce short functional peptides. Thus, the products of transposon transcription and translation are the most important sources of evolutionary transformations; these mechanisms could be the basis for the evolution of viruses and the emergence of the fundamental properties of living organisms when they appear.", 
        "genre": "research_article", 
        "id": "sg:pub.10.3103/s0891416818040067", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1097703", 
            "issn": [
              "0891-4168", 
              "1934-841X"
            ], 
            "name": "Molecular Genetics, Microbiology and Virology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "33"
          }
        ], 
        "name": "Hypothesis on the Origin of Viruses from Transposons", 
        "pagination": "223-232", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5f0d8ea60f9dc08a2208448c2ed982795a339a6446cfa863ceb7ef9028e316d7"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.3103/s0891416818040067"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112469731"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.3103/s0891416818040067", 
          "https://app.dimensions.ai/details/publication/pub.1112469731"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113644_00000005.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.3103%2FS0891416818040067"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.3103/s0891416818040067'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.3103/s0891416818040067'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.3103/s0891416818040067'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.3103/s0891416818040067'


     

    This table displays all metadata directly associated to this object as RDF triples.

    299 TRIPLES      21 PREDICATES      100 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.3103/s0891416818040067 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N3ea413a69d8a4742a7a48749ff6003f7
    4 schema:citation sg:pub.10.1007/978-1-62703-679-5_8
    5 sg:pub.10.1007/s00438-015-1010-1
    6 sg:pub.10.1007/s10709-011-9569-x
    7 sg:pub.10.1038/ncomms7644
    8 sg:pub.10.1038/nrg.2016.139
    9 sg:pub.10.1038/nrg2165
    10 sg:pub.10.1038/nrg2337
    11 sg:pub.10.1038/nrg3520
    12 sg:pub.10.1038/nrm.2017.104
    13 sg:pub.10.1038/nrmicro3389
    14 sg:pub.10.1038/nsmb.2338
    15 sg:pub.10.1186/1471-2164-14-134
    16 sg:pub.10.1186/1742-4690-10-132
    17 sg:pub.10.1186/1743-422x-10-132
    18 sg:pub.10.1186/1745-6150-4-41
    19 sg:pub.10.1186/1745-6150-9-6
    20 sg:pub.10.1186/gb-2014-15-1-r6
    21 sg:pub.10.1186/s12859-015-0507-2
    22 sg:pub.10.1186/s12915-015-0145-1
    23 sg:pub.10.1186/s12915-015-0207-4
    24 https://app.dimensions.ai/details/publication/pub.1078393047
    25 https://doi.org/10.1002/embj.201488411
    26 https://doi.org/10.1002/j.1460-2075.1990.tb07536.x
    27 https://doi.org/10.1016/j.cell.2011.10.002
    28 https://doi.org/10.1016/j.cell.2015.01.009
    29 https://doi.org/10.1016/j.cell.2017.12.024
    30 https://doi.org/10.1016/j.dci.2017.11.013
    31 https://doi.org/10.1016/j.gene.2015.01.039
    32 https://doi.org/10.1016/j.mib.2016.01.006
    33 https://doi.org/10.1016/j.smim.2009.11.004
    34 https://doi.org/10.1016/j.virol.2015.02.039
    35 https://doi.org/10.1016/j.ympev.2014.05.024
    36 https://doi.org/10.1073/pnas.0509720103
    37 https://doi.org/10.1073/pnas.0509809103
    38 https://doi.org/10.1073/pnas.0600833103
    39 https://doi.org/10.1073/pnas.0806548105
    40 https://doi.org/10.1073/pnas.1116168109
    41 https://doi.org/10.1073/pnas.1317811111
    42 https://doi.org/10.1073/pnas.83.8.2531
    43 https://doi.org/10.1073/pnas.93.18.9454
    44 https://doi.org/10.1080/15476286.2015.1094601
    45 https://doi.org/10.1093/bioinformatics/btv132
    46 https://doi.org/10.1093/database/bav004
    47 https://doi.org/10.1093/database/bax102
    48 https://doi.org/10.1093/gbe/evu112
    49 https://doi.org/10.1093/gbe/evu140
    50 https://doi.org/10.1093/gbe/evv049
    51 https://doi.org/10.1093/gbe/evx122
    52 https://doi.org/10.1093/molbev/msv042
    53 https://doi.org/10.1093/molbev/msx275
    54 https://doi.org/10.1093/nar/gki236
    55 https://doi.org/10.1105/tpc.15.00920
    56 https://doi.org/10.1111/nyas.12728
    57 https://doi.org/10.1126/sciadv.aao2110
    58 https://doi.org/10.1126/science.1199412
    59 https://doi.org/10.1126/science.aad4076
    60 https://doi.org/10.1128/9781555819217
    61 https://doi.org/10.1128/jvi.03653-14
    62 https://doi.org/10.1261/rna.044560.114
    63 https://doi.org/10.1371/journal.pbio.2001536
    64 https://doi.org/10.1371/journal.pgen.1002942
    65 https://doi.org/10.1371/journal.pgen.1006883
    66 https://doi.org/10.1371/journal.pone.0114083
    67 https://doi.org/10.1371/journal.ppat.1005279
    68 https://doi.org/10.1534/genetics.107.084491
    69 https://doi.org/10.2222/jsv.61.25
    70 https://doi.org/10.3389/fpls.2016.01436
    71 https://doi.org/10.3390/v7031238
    72 https://doi.org/10.3748/wjg.v20.i33.11630
    73 https://doi.org/10.5808/gi.2014.12.4.261
    74 https://doi.org/10.7150/thno.24677
    75 https://doi.org/10.7554/elife.03523
    76 https://doi.org/10.7554/elife.10565
    77 schema:datePublished 2018-10
    78 schema:datePublishedReg 2018-10-01
    79 schema:description In this review, the role of transposons in the origin of viruses, losing the traits of their evolutionary precursors due to their high mutability, is considered. However, there are a number of common properties of viruses and transposons suggesting their phylogenetic relationship, including the ability to integrate into the host genome, specific activation in certain tissues, high degree of mutability, the existence of virophages propagating only in the presence of another virus (which is similar to non-autonomous transposons, for which the expression products of autonomous ones are required). Ideas about the emergence of viruses from transposons in evolution are discussed. The genomic elements exhibiting a dual nature of existence as mobile genetic elements and viruses are found: polintons, Tlr elements, and PLV viruses. It is assumed that a horizontal transfer (HT) of transposons, during the natural selection of which the elements possessing the virulence properties are preserved (while the genes required for the integration can mutate), is a key event required for turning into viruses. The horizontal transposon transfer, which is common in all representatives of living organisms, is accompanied by their variability required for the acquisition of new adaptive traits. In the course of evolution, the mechanisms of protection against viruses and transposons, including RNA interference, DNA methylation, and histone modification, began to be used to control the operation of the genomes, providing intercellular interactions; this explains the emergence of multicellular organisms. In the evolution of eukaryotes, the transposons have been used successfully for transformations of regulatory gene networks, as well as possible sources of new genes encoding both proteins and non-coding RNA, the fragmentary translation of which can produce short functional peptides. Thus, the products of transposon transcription and translation are the most important sources of evolutionary transformations; these mechanisms could be the basis for the evolution of viruses and the emergence of the fundamental properties of living organisms when they appear.
    80 schema:genre research_article
    81 schema:inLanguage en
    82 schema:isAccessibleForFree false
    83 schema:isPartOf N8521f87e632c4f4eafac1accc37d1334
    84 Nc7bc88811efd432a88d5711616e9cbad
    85 sg:journal.1097703
    86 schema:name Hypothesis on the Origin of Viruses from Transposons
    87 schema:pagination 223-232
    88 schema:productId N7fb55a7b448843b095a8518ebbae4ade
    89 N8a85c44cdf5148a1aa9023c707c70033
    90 N947ac04bf22247e4a383d5192026ba46
    91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112469731
    92 https://doi.org/10.3103/s0891416818040067
    93 schema:sdDatePublished 2019-04-11T10:30
    94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    95 schema:sdPublisher Ne4a8874117c04080b388c19946022db7
    96 schema:url https://link.springer.com/10.3103%2FS0891416818040067
    97 sgo:license sg:explorer/license/
    98 sgo:sdDataset articles
    99 rdf:type schema:ScholarlyArticle
    100 N0bca8533e37347c68e4f4fdbea351fd8 schema:affiliation https://www.grid.ac/institutes/grid.77269.3d
    101 schema:familyName Mustafin
    102 schema:givenName R. N.
    103 rdf:type schema:Person
    104 N3ea413a69d8a4742a7a48749ff6003f7 rdf:first N0bca8533e37347c68e4f4fdbea351fd8
    105 rdf:rest rdf:nil
    106 N7fb55a7b448843b095a8518ebbae4ade schema:name doi
    107 schema:value 10.3103/s0891416818040067
    108 rdf:type schema:PropertyValue
    109 N8521f87e632c4f4eafac1accc37d1334 schema:volumeNumber 33
    110 rdf:type schema:PublicationVolume
    111 N8a85c44cdf5148a1aa9023c707c70033 schema:name dimensions_id
    112 schema:value pub.1112469731
    113 rdf:type schema:PropertyValue
    114 N947ac04bf22247e4a383d5192026ba46 schema:name readcube_id
    115 schema:value 5f0d8ea60f9dc08a2208448c2ed982795a339a6446cfa863ceb7ef9028e316d7
    116 rdf:type schema:PropertyValue
    117 Nc7bc88811efd432a88d5711616e9cbad schema:issueNumber 4
    118 rdf:type schema:PublicationIssue
    119 Ne4a8874117c04080b388c19946022db7 schema:name Springer Nature - SN SciGraph project
    120 rdf:type schema:Organization
    121 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    122 schema:name Biological Sciences
    123 rdf:type schema:DefinedTerm
    124 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    125 schema:name Genetics
    126 rdf:type schema:DefinedTerm
    127 sg:journal.1097703 schema:issn 0891-4168
    128 1934-841X
    129 schema:name Molecular Genetics, Microbiology and Virology
    130 rdf:type schema:Periodical
    131 sg:pub.10.1007/978-1-62703-679-5_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000067141
    132 https://doi.org/10.1007/978-1-62703-679-5_8
    133 rdf:type schema:CreativeWork
    134 sg:pub.10.1007/s00438-015-1010-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006964518
    135 https://doi.org/10.1007/s00438-015-1010-1
    136 rdf:type schema:CreativeWork
    137 sg:pub.10.1007/s10709-011-9569-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032502601
    138 https://doi.org/10.1007/s10709-011-9569-x
    139 rdf:type schema:CreativeWork
    140 sg:pub.10.1038/ncomms7644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032261677
    141 https://doi.org/10.1038/ncomms7644
    142 rdf:type schema:CreativeWork
    143 sg:pub.10.1038/nrg.2016.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034466564
    144 https://doi.org/10.1038/nrg.2016.139
    145 rdf:type schema:CreativeWork
    146 sg:pub.10.1038/nrg2165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053647019
    147 https://doi.org/10.1038/nrg2165
    148 rdf:type schema:CreativeWork
    149 sg:pub.10.1038/nrg2337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036005113
    150 https://doi.org/10.1038/nrg2337
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1038/nrg3520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018701184
    153 https://doi.org/10.1038/nrg3520
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1038/nrm.2017.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092689395
    156 https://doi.org/10.1038/nrm.2017.104
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1038/nrmicro3389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007677483
    159 https://doi.org/10.1038/nrmicro3389
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1038/nsmb.2338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019935618
    162 https://doi.org/10.1038/nsmb.2338
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1186/1471-2164-14-134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016802646
    165 https://doi.org/10.1186/1471-2164-14-134
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1186/1742-4690-10-132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042422235
    168 https://doi.org/10.1186/1742-4690-10-132
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1186/1743-422x-10-132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043037167
    171 https://doi.org/10.1186/1743-422x-10-132
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1186/1745-6150-4-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034655595
    174 https://doi.org/10.1186/1745-6150-4-41
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1186/1745-6150-9-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015316770
    177 https://doi.org/10.1186/1745-6150-9-6
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1186/gb-2014-15-1-r6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047079213
    180 https://doi.org/10.1186/gb-2014-15-1-r6
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1186/s12859-015-0507-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044238183
    183 https://doi.org/10.1186/s12859-015-0507-2
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1186/s12915-015-0145-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018199349
    186 https://doi.org/10.1186/s12915-015-0145-1
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1186/s12915-015-0207-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021268326
    189 https://doi.org/10.1186/s12915-015-0207-4
    190 rdf:type schema:CreativeWork
    191 https://app.dimensions.ai/details/publication/pub.1078393047 schema:CreativeWork
    192 https://doi.org/10.1002/embj.201488411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041744407
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1002/j.1460-2075.1990.tb07536.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077299052
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1016/j.cell.2011.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042102077
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1016/j.cell.2015.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018653093
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/j.cell.2017.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100318359
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1016/j.dci.2017.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092957265
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.gene.2015.01.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047892845
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.mib.2016.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026153362
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.smim.2009.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031471979
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.virol.2015.02.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006379629
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.ympev.2014.05.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036373036
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1073/pnas.0509720103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003606007
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1073/pnas.0509809103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049171285
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1073/pnas.0600833103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023435534
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1073/pnas.0806548105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013703484
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1073/pnas.1116168109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004076082
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1073/pnas.1317811111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052895568
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1073/pnas.83.8.2531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036087388
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1073/pnas.93.18.9454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039283292
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1080/15476286.2015.1094601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058403040
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1093/bioinformatics/btv132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049547692
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1093/database/bav004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021384128
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1093/database/bax102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099890057
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1093/gbe/evu112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002634126
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1093/gbe/evu140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001892697
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1093/gbe/evv049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010661404
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1093/gbe/evx122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090336650
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1093/molbev/msv042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048917678
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1093/molbev/msx275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092359497
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1093/nar/gki236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036540062
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1105/tpc.15.00920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060842238
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1111/nyas.12728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048533705
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1126/sciadv.aao2110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091975604
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1126/science.1199412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062463045
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1126/science.aad4076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021434601
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1128/9781555819217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109532691
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1128/jvi.03653-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035317846
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1261/rna.044560.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013276175
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1371/journal.pbio.2001536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083840025
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1371/journal.pgen.1002942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019708754
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1371/journal.pgen.1006883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090650952
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1371/journal.pone.0114083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008499122
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1371/journal.ppat.1005279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046884688
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1534/genetics.107.084491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033940524
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.2222/jsv.61.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034547987
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.3389/fpls.2016.01436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017405615
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.3390/v7031238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006187831
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.3748/wjg.v20.i33.11630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071371352
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.5808/gi.2014.12.4.261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022676779
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.7150/thno.24677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103654410
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.7554/elife.03523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028980661
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.7554/elife.10565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034880122
    295 rdf:type schema:CreativeWork
    296 https://www.grid.ac/institutes/grid.77269.3d schema:alternateName Bashkir State University
    297 schema:name Bashkir State Medical University, 450008, Ufa, Russia
    298 Bashkir State University, 450076, Ufa, Russia
    299 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...