Particular Features of Diphtheria Toxin Internalization by Resistant and Sensitive Mammalian Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

K. Y. Manoilov, A. Ju. Labyntsev, N. V. Korotkevych, I. S. Maksymovych, D. V. Kolybo, S. V. Komisarenko

ABSTRACT

Several mammalian species are resistant to diphtheria toxin (DT). The DT receptor, proHB-EGF in resistant and sensitive species, has a different primary structure due to the amino acid substitutions; however, there is no definite opinion regarding how the difference in primary receptor structure alters the process of DT internalization by resistant cells compared to sensitive. The aim of the present study was to evaluate the role of DT internalization in the development of DT resistance of mammalian cells. It was shown that L929 cells resistant to toxin and derived from the C3H mouse strain absorb the recombinant fluorescent subunit B of DT with the value of binding constant Kb that was close to that of African green monkey Vero cells highly sensitive to toxin (0.269 and 0.372 μM, respectively). Endocytosis dynamics analysis by confocal microscopy indicated that the amount of subunit B internalized by Vero varied from nearly equal (at early stages of the process) to approximately 2‒5 times bigger (after 30 min) compared to L929 cells. The obtained results suggest that, at the initial stages, DT is internalized by resistant cells as rapidly as by sensitive cells. Nevertheless, at further stages of uptake, toxin amount in cells sufficiently varies depending on the receptor expression level and physiological features of the cell culture. It was concluded that the internalization and, therefore, the resistance of cells to the DT depends insufficiently on receptor structure in resistant and sensitive species but may be dependent on subsequent endosomal transport and accumulation of DT molecules in cells at late stages of internalization. More... »

PAGES

353-359

References to SciGraph publications

  • 2014-07. Recombinant fluorescent models for studying the diphtheria toxin in RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
  • 2012-07. Fiji: an open-source platform for biological-image analysis in NATURE METHODS
  • 2011-10. Refolding of proteins from inclusion bodies: rational design and recipes in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.3103/s0095452718050080

    DOI

    http://dx.doi.org/10.3103/s0095452718050080

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107497288


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Palladin Institute of Biochemistry", 
              "id": "https://www.grid.ac/institutes/grid.419966.5", 
              "name": [
                "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 01601, Kyiv, Ukraine"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manoilov", 
            "givenName": "K. Y.", 
            "id": "sg:person.012235766737.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012235766737.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Palladin Institute of Biochemistry", 
              "id": "https://www.grid.ac/institutes/grid.419966.5", 
              "name": [
                "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 01601, Kyiv, Ukraine"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Labyntsev", 
            "givenName": "A. Ju.", 
            "id": "sg:person.011610460077.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011610460077.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Palladin Institute of Biochemistry", 
              "id": "https://www.grid.ac/institutes/grid.419966.5", 
              "name": [
                "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 01601, Kyiv, Ukraine"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korotkevych", 
            "givenName": "N. V.", 
            "id": "sg:person.0621151726.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621151726.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Palladin Institute of Biochemistry", 
              "id": "https://www.grid.ac/institutes/grid.419966.5", 
              "name": [
                "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 01601, Kyiv, Ukraine"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maksymovych", 
            "givenName": "I. S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Palladin Institute of Biochemistry", 
              "id": "https://www.grid.ac/institutes/grid.419966.5", 
              "name": [
                "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 01601, Kyiv, Ukraine"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kolybo", 
            "givenName": "D. V.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Palladin Institute of Biochemistry", 
              "id": "https://www.grid.ac/institutes/grid.419966.5", 
              "name": [
                "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 01601, Kyiv, Ukraine"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Komisarenko", 
            "givenName": "S. V.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1006/bbrc.1993.1020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000567715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.5560030912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000652557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90623-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008564675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.43.27084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015730753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2008.06326.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017841856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-011-3513-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017919827", 
              "https://doi.org/10.1007/s00253-011-3513-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.123.4.723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020324124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biologicals.2005.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023781420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026706357", 
              "https://doi.org/10.1038/nmeth.2019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.1041350307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029959847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1134/s1068162014040086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035909180", 
              "https://doi.org/10.1134/s1068162014040086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.3.1015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037081400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.3.7.1283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041070182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1997.3921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041733745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075271593", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077176197", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/9.3.229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077543674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077978328", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078430701", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.1989.257.2.c182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078898777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081876084", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082276787", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.10.1.8566547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082861802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083196846", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-09", 
        "datePublishedReg": "2018-09-01", 
        "description": "Several mammalian species are resistant to diphtheria toxin (DT). The DT receptor, proHB-EGF in resistant and sensitive species, has a different primary structure due to the amino acid substitutions; however, there is no definite opinion regarding how the difference in primary receptor structure alters the process of DT internalization by resistant cells compared to sensitive. The aim of the present study was to evaluate the role of DT internalization in the development of DT resistance of mammalian cells. It was shown that L929 cells resistant to toxin and derived from the C3H mouse strain absorb the recombinant fluorescent subunit B of DT with the value of binding constant Kb that was close to that of African green monkey Vero cells highly sensitive to toxin (0.269 and 0.372 \u03bcM, respectively). Endocytosis dynamics analysis by confocal microscopy indicated that the amount of subunit B internalized by Vero varied from nearly equal (at early stages of the process) to approximately 2\u20125 times bigger (after 30 min) compared to L929 cells. The obtained results suggest that, at the initial stages, DT is internalized by resistant cells as rapidly as by sensitive cells. Nevertheless, at further stages of uptake, toxin amount in cells sufficiently varies depending on the receptor expression level and physiological features of the cell culture. It was concluded that the internalization and, therefore, the resistance of cells to the DT depends insufficiently on receptor structure in resistant and sensitive species but may be dependent on subsequent endosomal transport and accumulation of DT molecules in cells at late stages of internalization.", 
        "genre": "research_article", 
        "id": "sg:pub.10.3103/s0095452718050080", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1007409", 
            "issn": [
              "0095-4527", 
              "1934-9440"
            ], 
            "name": "Cytology and Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "52"
          }
        ], 
        "name": "Particular Features of Diphtheria Toxin Internalization by Resistant and Sensitive Mammalian Cells", 
        "pagination": "353-359", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8dc93fc116c57b3e597ca5df27c89c75587d090d8a4f35d25db6e479e5dffa6b"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.3103/s0095452718050080"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1107497288"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.3103/s0095452718050080", 
          "https://app.dimensions.ai/details/publication/pub.1107497288"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000609.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.3103%2FS0095452718050080"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.3103/s0095452718050080'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.3103/s0095452718050080'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.3103/s0095452718050080'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.3103/s0095452718050080'


     

    This table displays all metadata directly associated to this object as RDF triples.

    161 TRIPLES      21 PREDICATES      51 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.3103/s0095452718050080 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Nc4569e053b8445e6b10dd96e2dbfba4c
    4 schema:citation sg:pub.10.1007/s00253-011-3513-y
    5 sg:pub.10.1038/nmeth.2019
    6 sg:pub.10.1134/s1068162014040086
    7 https://app.dimensions.ai/details/publication/pub.1075271593
    8 https://app.dimensions.ai/details/publication/pub.1077176197
    9 https://app.dimensions.ai/details/publication/pub.1077978328
    10 https://app.dimensions.ai/details/publication/pub.1078430701
    11 https://app.dimensions.ai/details/publication/pub.1081876084
    12 https://app.dimensions.ai/details/publication/pub.1082276787
    13 https://app.dimensions.ai/details/publication/pub.1083196846
    14 https://doi.org/10.1002/jcp.1041350307
    15 https://doi.org/10.1002/pro.5560030912
    16 https://doi.org/10.1006/bbrc.1993.1020
    17 https://doi.org/10.1006/excr.1997.3921
    18 https://doi.org/10.1016/0092-8674(92)90623-k
    19 https://doi.org/10.1016/j.biologicals.2005.03.002
    20 https://doi.org/10.1074/jbc.270.3.1015
    21 https://doi.org/10.1074/jbc.272.43.27084
    22 https://doi.org/10.1084/jem.123.4.723
    23 https://doi.org/10.1093/jnci/9.3.229
    24 https://doi.org/10.1096/fasebj.10.1.8566547
    25 https://doi.org/10.1111/j.1742-4658.2008.06326.x
    26 https://doi.org/10.1128/mcb.3.7.1283
    27 https://doi.org/10.1152/ajpcell.1989.257.2.c182
    28 schema:datePublished 2018-09
    29 schema:datePublishedReg 2018-09-01
    30 schema:description Several mammalian species are resistant to diphtheria toxin (DT). The DT receptor, proHB-EGF in resistant and sensitive species, has a different primary structure due to the amino acid substitutions; however, there is no definite opinion regarding how the difference in primary receptor structure alters the process of DT internalization by resistant cells compared to sensitive. The aim of the present study was to evaluate the role of DT internalization in the development of DT resistance of mammalian cells. It was shown that L929 cells resistant to toxin and derived from the C3H mouse strain absorb the recombinant fluorescent subunit B of DT with the value of binding constant Kb that was close to that of African green monkey Vero cells highly sensitive to toxin (0.269 and 0.372 μM, respectively). Endocytosis dynamics analysis by confocal microscopy indicated that the amount of subunit B internalized by Vero varied from nearly equal (at early stages of the process) to approximately 2‒5 times bigger (after 30 min) compared to L929 cells. The obtained results suggest that, at the initial stages, DT is internalized by resistant cells as rapidly as by sensitive cells. Nevertheless, at further stages of uptake, toxin amount in cells sufficiently varies depending on the receptor expression level and physiological features of the cell culture. It was concluded that the internalization and, therefore, the resistance of cells to the DT depends insufficiently on receptor structure in resistant and sensitive species but may be dependent on subsequent endosomal transport and accumulation of DT molecules in cells at late stages of internalization.
    31 schema:genre research_article
    32 schema:inLanguage en
    33 schema:isAccessibleForFree false
    34 schema:isPartOf N79bd780d4ceb4856bd2a2a243e301dd8
    35 Ne68854901fda4cf7aecd21b809f970d4
    36 sg:journal.1007409
    37 schema:name Particular Features of Diphtheria Toxin Internalization by Resistant and Sensitive Mammalian Cells
    38 schema:pagination 353-359
    39 schema:productId N35e190e45a9c43988118d62f797224e0
    40 Nac9f2e6e37da44ff8e1e7f1e32d3f14f
    41 Nf876b32453ce4b7988ddaab3ee236650
    42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107497288
    43 https://doi.org/10.3103/s0095452718050080
    44 schema:sdDatePublished 2019-04-10T16:56
    45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    46 schema:sdPublisher N80f699773e6f4680b5b2473cfcf4b637
    47 schema:url https://link.springer.com/10.3103%2FS0095452718050080
    48 sgo:license sg:explorer/license/
    49 sgo:sdDataset articles
    50 rdf:type schema:ScholarlyArticle
    51 N23653b5090ca4b3da133bea1f60d5c7b schema:affiliation https://www.grid.ac/institutes/grid.419966.5
    52 schema:familyName Kolybo
    53 schema:givenName D. V.
    54 rdf:type schema:Person
    55 N35e190e45a9c43988118d62f797224e0 schema:name doi
    56 schema:value 10.3103/s0095452718050080
    57 rdf:type schema:PropertyValue
    58 N4cddbb7920d9438b87e25e5bc06861b2 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
    59 schema:familyName Komisarenko
    60 schema:givenName S. V.
    61 rdf:type schema:Person
    62 N5877066969f64c8c974b7b0ad83ec60f rdf:first N6a3d96b58395481a809a1ef8261d9c0e
    63 rdf:rest N8eb56309c95e42498bcf2b9992380e42
    64 N6a3d96b58395481a809a1ef8261d9c0e schema:affiliation https://www.grid.ac/institutes/grid.419966.5
    65 schema:familyName Maksymovych
    66 schema:givenName I. S.
    67 rdf:type schema:Person
    68 N6d5ce5b310f84e8c99d5d3099afc7c83 rdf:first sg:person.011610460077.42
    69 rdf:rest N73e61809ee7e4a2b830a6ff4f5f9a7cd
    70 N73e61809ee7e4a2b830a6ff4f5f9a7cd rdf:first sg:person.0621151726.96
    71 rdf:rest N5877066969f64c8c974b7b0ad83ec60f
    72 N79bd780d4ceb4856bd2a2a243e301dd8 schema:volumeNumber 52
    73 rdf:type schema:PublicationVolume
    74 N80f699773e6f4680b5b2473cfcf4b637 schema:name Springer Nature - SN SciGraph project
    75 rdf:type schema:Organization
    76 N8eb56309c95e42498bcf2b9992380e42 rdf:first N23653b5090ca4b3da133bea1f60d5c7b
    77 rdf:rest Ndec9c2727ccf4074a3be7cff202b1b5b
    78 Nac9f2e6e37da44ff8e1e7f1e32d3f14f schema:name dimensions_id
    79 schema:value pub.1107497288
    80 rdf:type schema:PropertyValue
    81 Nc4569e053b8445e6b10dd96e2dbfba4c rdf:first sg:person.012235766737.71
    82 rdf:rest N6d5ce5b310f84e8c99d5d3099afc7c83
    83 Ndec9c2727ccf4074a3be7cff202b1b5b rdf:first N4cddbb7920d9438b87e25e5bc06861b2
    84 rdf:rest rdf:nil
    85 Ne68854901fda4cf7aecd21b809f970d4 schema:issueNumber 5
    86 rdf:type schema:PublicationIssue
    87 Nf876b32453ce4b7988ddaab3ee236650 schema:name readcube_id
    88 schema:value 8dc93fc116c57b3e597ca5df27c89c75587d090d8a4f35d25db6e479e5dffa6b
    89 rdf:type schema:PropertyValue
    90 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    91 schema:name Biological Sciences
    92 rdf:type schema:DefinedTerm
    93 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    94 schema:name Biochemistry and Cell Biology
    95 rdf:type schema:DefinedTerm
    96 sg:journal.1007409 schema:issn 0095-4527
    97 1934-9440
    98 schema:name Cytology and Genetics
    99 rdf:type schema:Periodical
    100 sg:person.011610460077.42 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
    101 schema:familyName Labyntsev
    102 schema:givenName A. Ju.
    103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011610460077.42
    104 rdf:type schema:Person
    105 sg:person.012235766737.71 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
    106 schema:familyName Manoilov
    107 schema:givenName K. Y.
    108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012235766737.71
    109 rdf:type schema:Person
    110 sg:person.0621151726.96 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
    111 schema:familyName Korotkevych
    112 schema:givenName N. V.
    113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621151726.96
    114 rdf:type schema:Person
    115 sg:pub.10.1007/s00253-011-3513-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1017919827
    116 https://doi.org/10.1007/s00253-011-3513-y
    117 rdf:type schema:CreativeWork
    118 sg:pub.10.1038/nmeth.2019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706357
    119 https://doi.org/10.1038/nmeth.2019
    120 rdf:type schema:CreativeWork
    121 sg:pub.10.1134/s1068162014040086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035909180
    122 https://doi.org/10.1134/s1068162014040086
    123 rdf:type schema:CreativeWork
    124 https://app.dimensions.ai/details/publication/pub.1075271593 schema:CreativeWork
    125 https://app.dimensions.ai/details/publication/pub.1077176197 schema:CreativeWork
    126 https://app.dimensions.ai/details/publication/pub.1077978328 schema:CreativeWork
    127 https://app.dimensions.ai/details/publication/pub.1078430701 schema:CreativeWork
    128 https://app.dimensions.ai/details/publication/pub.1081876084 schema:CreativeWork
    129 https://app.dimensions.ai/details/publication/pub.1082276787 schema:CreativeWork
    130 https://app.dimensions.ai/details/publication/pub.1083196846 schema:CreativeWork
    131 https://doi.org/10.1002/jcp.1041350307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029959847
    132 rdf:type schema:CreativeWork
    133 https://doi.org/10.1002/pro.5560030912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000652557
    134 rdf:type schema:CreativeWork
    135 https://doi.org/10.1006/bbrc.1993.1020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000567715
    136 rdf:type schema:CreativeWork
    137 https://doi.org/10.1006/excr.1997.3921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041733745
    138 rdf:type schema:CreativeWork
    139 https://doi.org/10.1016/0092-8674(92)90623-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1008564675
    140 rdf:type schema:CreativeWork
    141 https://doi.org/10.1016/j.biologicals.2005.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023781420
    142 rdf:type schema:CreativeWork
    143 https://doi.org/10.1074/jbc.270.3.1015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037081400
    144 rdf:type schema:CreativeWork
    145 https://doi.org/10.1074/jbc.272.43.27084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015730753
    146 rdf:type schema:CreativeWork
    147 https://doi.org/10.1084/jem.123.4.723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020324124
    148 rdf:type schema:CreativeWork
    149 https://doi.org/10.1093/jnci/9.3.229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077543674
    150 rdf:type schema:CreativeWork
    151 https://doi.org/10.1096/fasebj.10.1.8566547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082861802
    152 rdf:type schema:CreativeWork
    153 https://doi.org/10.1111/j.1742-4658.2008.06326.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017841856
    154 rdf:type schema:CreativeWork
    155 https://doi.org/10.1128/mcb.3.7.1283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041070182
    156 rdf:type schema:CreativeWork
    157 https://doi.org/10.1152/ajpcell.1989.257.2.c182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078898777
    158 rdf:type schema:CreativeWork
    159 https://www.grid.ac/institutes/grid.419966.5 schema:alternateName Palladin Institute of Biochemistry
    160 schema:name Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 01601, Kyiv, Ukraine
    161 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...