Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion View Full Text


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Article Info

DATE

2017-09

AUTHORS

K. V. Storozhenko, V. M. Shkarupa

ABSTRACT

The molecular-genetic testing of the polymorphic rs2981579 (C>T) locus of the FGFR2 gene as the marker of increased predisposition to the development of mesial occlusion was carried out in 110 patients with mesial occlusion and 103 general-population control subjects from Ukraine. It was shown that polymorphism rs2981579 in gene FGFR2 is associated with mesial occlusion (OR = 1.67, 95% CI = 1.14–2.45, p = 0.009). Compared to CC carriers, TT+CT carriers had a 3.21-fold higher risk of mesial occlusion (95% CI = 1.57–6.57, p = 0.001). We found the protective effect of the homozygous allele C on mesial occlusion development (OR = 0.31, p = 0.001). This is the first published data on FGFR2 polymorphisms rs2981579 (C>T) in patients with mesial occlusion. More... »

PAGES

361-364

References to SciGraph publications

  • 1990. Fibroblast Growth Factors in PEPTIDE GROWTH FACTORS AND THEIR RECEPTORS I
  • 2012-12. Three novel functional polymorphisms in the promoter of FGFR2 gene and breast cancer risk: a HuGE review and meta-analysis in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-03. The FGF family: biology, pathophysiology and therapy in NATURE REVIEWS DRUG DISCOVERY
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