Flow Cytometry Analysis of G0/G1 Diploid Cell Fraction in Ovarian Cancer Tissue View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

T. A. Bogush, I. A. Mamichev, Iu. P. Borisenko, E. A. Bogush, N. O. Vichljantseva, V. Ju. Kirsanov

ABSTRACT

The proportion of diploid cells in the G0/G1 cell cycle phases was estimated by flow cytometry in 60 samples of stage III serous ovarian cancer tissue. The tumor tissue shows considerable heterogeneity with regard to the content of this tissue fraction, which ranged from 27 to 95% with a median of 73%. Statistically significant differences in the size of this fraction were identified by comparing tumor subgroups sensitive and resistant to first-line platinum-taxane chemotherapy. Predictive significance of the G0/G1 fraction was concluded and quantitative evaluation of this fraction is recommended for clinical use. More... »

PAGES

244-247

Identifiers

URI

http://scigraph.springernature.com/pub.10.3103/s0027131418050024

DOI

http://dx.doi.org/10.3103/s0027131418050024

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110180420


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