Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

A. S. Solomatin, R. Y. Yakovlev, N. B. Leonidov, G. A. Badun, M. G. Chernysheva, I. I. Kulakova, A. N. Stavrianidi, O. A. Shlyakhtin, G. V. Lisichkin

ABSTRACT

The effect of the chemical nature of the surface of detonation nanodiamond on the adsorption of an antibiotic is revealed with the help of tritium-labeled amikacin. It is found that nanodiamonds with a carboxylated surface (Ssp = 283 ± 5 m2/g) chemisorbed twice as much amikacin as nanodiamonds with a hydrogenated surface (Ssp = 289 ± 5 m2/g): 48 and 22 mg/g, respectively. Maintaining nanodiamonds with immobilized amikacin in the form of hydrosol for 1 month results in a release of up to 9.6 and 6.4 mg/g of the antibiotic, respectively. The results demonstrate the possibility of creating an amikacin delivery system based on nanodiamonds. More... »

PAGES

91-98

Identifiers

URI

http://scigraph.springernature.com/pub.10.3103/s0027131418030082

DOI

http://dx.doi.org/10.3103/s0027131418030082

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105980041


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