The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

I. I. Nikolskaya, O. V. Beznos, A. I. Eltsov, I. V. Gachok, N. B. Chesnokova, V. P. Varlamov, O. A. Kost

ABSTRACT

Chitosan-covered calcium phosphate nanoparticles with the mean dynamic radii of 30 to 130 nm and ζ-potential of +22 ± 4 mV containing timolol and lisinopril are prepared and characterized. These particles are formed by the amorphous phase represented by amorphous calcium phosphate Cax(PO4)y · zH2O and the crystalline phase represented by hydrated calcium hydrophoshate (brushite) CaHPO4 · 2H2O. The experiments in vivo demonstrated that the inclusion of timolol into calcium phosphate particles covered with chitosan substantially prolonged its effect on the intraocular pressure. More... »

PAGES

85-89

Identifiers

URI

http://scigraph.springernature.com/pub.10.3103/s0027131418020116

DOI

http://dx.doi.org/10.3103/s0027131418020116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104303522


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