Protective effect of tea polyphenols on the blood-brain barrier View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09

AUTHORS

Rongliang Xue, Jianrui Lv, Jing Gao, Rongguo Fu, Wei Li, Xiaoming Lei, Gang Wu, Li Xue, Zhenni Zhang

ABSTRACT

This study was to investigate the protective effects of tea polyphenols on the blood-brain barrier (BBB) of rats with global cerebral ischemia/reperfusion (GCIR) injury. Sprague Dawley rats underwent four-vessel occlusion to construct the model of GCIR. Half an hour before complete occlusion, they were treated with tea polyphenols (TP) (6.4%; 100 or 200 mg/kg) via tail intravenous injection. 24 h after reperfusion, BBB permeability was evaluated by measuring brain water content (BWC) and residual amount of Evan’s blue dye in cerebral tissue. In addition to this, MMP-9 and collagen IV protein expression in cerebral tissue were also detected using immunohistochemistry. ANOVA and SNK-q were used to do statistical analysis. Statistical significance was considered at P<0.05. Compared to the untreated, the TP-treated rats had significantly decreased BWC (P<0.05), decreased residual amount of Evan’s blue dye in cerebral tissue (P<0.05), down-regulated MMP-9 (P<0.05) and up-regulated collagen IV expression in brain tissue (P<0.05). It can be concluded from these findings that TP may reduce the MMP-9 mediated collagen IV degradation caused by GCIR to protect the BBB. More... »

PAGES

295-301

Identifiers

URI

http://scigraph.springernature.com/pub.10.2478/s13380-013-0133-2

DOI

http://dx.doi.org/10.2478/s13380-013-0133-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045098454


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi Province, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xue", 
        "givenName": "Rongliang", 
        "id": "sg:person.01004430066.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004430066.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi Province, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lv", 
        "givenName": "Jianrui", 
        "id": "sg:person.01277357166.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277357166.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi Province, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Jing", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Nephrology, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "Rongguo", 
        "id": "sg:person.0655662031.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655662031.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi Province, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Wei", 
        "id": "sg:person.01162024270.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162024270.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi Province, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lei", 
        "givenName": "Xiaoming", 
        "id": "sg:person.01345472366.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345472366.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi Province, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Gang", 
        "id": "sg:person.01057427742.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057427742.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi Province, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xue", 
        "givenName": "Li", 
        "id": "sg:person.01355053070.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355053070.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi Province, P.R. China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhenni", 
        "id": "sg:person.01231243766.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231243766.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00210-005-1076-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001386324", 
          "https://doi.org/10.1007/s00210-005-1076-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-005-1076-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001386324", 
          "https://doi.org/10.1007/s00210-005-1076-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(03)03088-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003119186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(03)03088-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003119186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-006-9248-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005414923", 
          "https://doi.org/10.1007/s11064-006-9248-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000061888.71524.df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007257809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000061888.71524.df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007257809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000061888.71524.df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007257809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0361-9230(03)00139-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007318196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0361-9230(03)00139-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007318196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00015.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007450220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10408690390826464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011223761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000083051.93319.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018697483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000083051.93319.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018697483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2008.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020029663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11886-003-0085-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021631140", 
          "https://doi.org/10.1007/s11886-003-0085-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199605000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022110693", 
          "https://doi.org/10.1097/00004647-199605000-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199605000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022110693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199605000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022110693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/0703-mr-72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024340075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/0703-mr-72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024340075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035752663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035752663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ncl.2005.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038479123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-8741(02)00217-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041699953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-8741(02)00217-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041699953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2004.06.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042287172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199906000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046284558", 
          "https://doi.org/10.1097/00004647-199906000-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199906000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046284558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199906000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046284558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hs0302.104542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047095766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000182238.08510.c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047853452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000182238.08510.c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047853452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/089771502753754082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059201532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/2004-00032.aneja", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068964897", 
          "https://doi.org/10.2119/2004-00032.aneja"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/2004-00032.aneja", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068964897", 
          "https://doi.org/10.2119/2004-00032.aneja"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/2004-00032.aneja", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068964897", 
          "https://doi.org/10.2119/2004-00032.aneja"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078357161", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-09", 
    "datePublishedReg": "2013-09-01", 
    "description": "This study was to investigate the protective effects of tea polyphenols on the blood-brain barrier (BBB) of rats with global cerebral ischemia/reperfusion (GCIR) injury. Sprague Dawley rats underwent four-vessel occlusion to construct the model of GCIR. Half an hour before complete occlusion, they were treated with tea polyphenols (TP) (6.4%; 100 or 200 mg/kg) via tail intravenous injection. 24 h after reperfusion, BBB permeability was evaluated by measuring brain water content (BWC) and residual amount of Evan\u2019s blue dye in cerebral tissue. In addition to this, MMP-9 and collagen IV protein expression in cerebral tissue were also detected using immunohistochemistry. ANOVA and SNK-q were used to do statistical analysis. Statistical significance was considered at P<0.05. Compared to the untreated, the TP-treated rats had significantly decreased BWC (P<0.05), decreased residual amount of Evan\u2019s blue dye in cerebral tissue (P<0.05), down-regulated MMP-9 (P<0.05) and up-regulated collagen IV expression in brain tissue (P<0.05). It can be concluded from these findings that TP may reduce the MMP-9 mediated collagen IV degradation caused by GCIR to protect the BBB.", 
    "genre": "research_article", 
    "id": "sg:pub.10.2478/s13380-013-0133-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1044565", 
        "issn": [
          "2081-3856", 
          "2081-6936"
        ], 
        "name": "Translational Neuroscience", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Protective effect of tea polyphenols on the blood-brain barrier", 
    "pagination": "295-301", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d6d17a8475e4d73397c2649edd02ffd02382abf4ce129d7df55b6caf3d64c9aa"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.2478/s13380-013-0133-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045098454"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.2478/s13380-013-0133-2", 
      "https://app.dimensions.ai/details/publication/pub.1045098454"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000507.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.2478/s13380-013-0133-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2478/s13380-013-0133-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2478/s13380-013-0133-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2478/s13380-013-0133-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2478/s13380-013-0133-2'


 

This table displays all metadata directly associated to this object as RDF triples.

194 TRIPLES      21 PREDICATES      51 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.2478/s13380-013-0133-2 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N0b724e091c3e46e0b4f1484ff3228f25
4 schema:citation sg:pub.10.1007/s00210-005-1076-0
5 sg:pub.10.1007/s11064-006-9248-y
6 sg:pub.10.1007/s11886-003-0085-1
7 sg:pub.10.1097/00004647-199605000-00002
8 sg:pub.10.1097/00004647-199906000-00005
9 sg:pub.10.2119/2004-00032.aneja
10 https://app.dimensions.ai/details/publication/pub.1078357161
11 https://doi.org/10.1016/j.nbd.2008.08.005
12 https://doi.org/10.1016/j.ncl.2005.10.004
13 https://doi.org/10.1016/j.neuroscience.2004.06.046
14 https://doi.org/10.1016/s0006-8993(03)03088-9
15 https://doi.org/10.1016/s0361-9230(03)00139-4
16 https://doi.org/10.1016/s0378-8741(02)00217-9
17 https://doi.org/10.1038/sj.jcbfm.9600048
18 https://doi.org/10.1080/10408690390826464
19 https://doi.org/10.1089/089771502753754082
20 https://doi.org/10.1097/00004647-199605000-00002
21 https://doi.org/10.1097/00004647-199906000-00005
22 https://doi.org/10.1152/physiol.00015.2009
23 https://doi.org/10.1161/01.str.0000061888.71524.df
24 https://doi.org/10.1161/01.str.0000083051.93319.28
25 https://doi.org/10.1161/01.str.0000182238.08510.c5
26 https://doi.org/10.1161/hs0302.104542
27 https://doi.org/10.3181/0703-mr-72
28 schema:datePublished 2013-09
29 schema:datePublishedReg 2013-09-01
30 schema:description This study was to investigate the protective effects of tea polyphenols on the blood-brain barrier (BBB) of rats with global cerebral ischemia/reperfusion (GCIR) injury. Sprague Dawley rats underwent four-vessel occlusion to construct the model of GCIR. Half an hour before complete occlusion, they were treated with tea polyphenols (TP) (6.4%; 100 or 200 mg/kg) via tail intravenous injection. 24 h after reperfusion, BBB permeability was evaluated by measuring brain water content (BWC) and residual amount of Evan’s blue dye in cerebral tissue. In addition to this, MMP-9 and collagen IV protein expression in cerebral tissue were also detected using immunohistochemistry. ANOVA and SNK-q were used to do statistical analysis. Statistical significance was considered at P<0.05. Compared to the untreated, the TP-treated rats had significantly decreased BWC (P<0.05), decreased residual amount of Evan’s blue dye in cerebral tissue (P<0.05), down-regulated MMP-9 (P<0.05) and up-regulated collagen IV expression in brain tissue (P<0.05). It can be concluded from these findings that TP may reduce the MMP-9 mediated collagen IV degradation caused by GCIR to protect the BBB.
31 schema:genre research_article
32 schema:inLanguage en
33 schema:isAccessibleForFree true
34 schema:isPartOf N024e183f3dfd4b499eac716117742a7f
35 N9a3205c2f4f248739b3ec289bc7cb96f
36 sg:journal.1044565
37 schema:name Protective effect of tea polyphenols on the blood-brain barrier
38 schema:pagination 295-301
39 schema:productId N0fcab2335a384c98a34763ddba1bf245
40 N90a21ee5e0504389b3cad70cc689c41e
41 Na72fc3b12d2b4e14be9599bf4355ea8e
42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045098454
43 https://doi.org/10.2478/s13380-013-0133-2
44 schema:sdDatePublished 2019-04-11T01:06
45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
46 schema:sdPublisher Nc96cb52def474885a08a43bf010b347a
47 schema:url http://link.springer.com/10.2478/s13380-013-0133-2
48 sgo:license sg:explorer/license/
49 sgo:sdDataset articles
50 rdf:type schema:ScholarlyArticle
51 N024e183f3dfd4b499eac716117742a7f schema:volumeNumber 4
52 rdf:type schema:PublicationVolume
53 N0b724e091c3e46e0b4f1484ff3228f25 rdf:first sg:person.01004430066.41
54 rdf:rest N8cf5bf0f0c5e4058b0aa73f807e05023
55 N0fcab2335a384c98a34763ddba1bf245 schema:name readcube_id
56 schema:value d6d17a8475e4d73397c2649edd02ffd02382abf4ce129d7df55b6caf3d64c9aa
57 rdf:type schema:PropertyValue
58 N1230259a24f24c5ca7e053768d07f82d rdf:first sg:person.01345472366.13
59 rdf:rest N715ccf214afd4514a5dc8ef6eec85583
60 N3937bbc2af08471882cbe2cf40bdb4a3 rdf:first sg:person.01231243766.51
61 rdf:rest rdf:nil
62 N5cfdb2a3cd894265bcc4bc6fddc0d254 rdf:first Ne6114e642eb74f9f9bf920a436553f52
63 rdf:rest Nb55c83dacf434700990290548ca7320d
64 N715ccf214afd4514a5dc8ef6eec85583 rdf:first sg:person.01057427742.09
65 rdf:rest Nd70ebe99d9e14f3f842d56ea47c8fcb4
66 N8cf5bf0f0c5e4058b0aa73f807e05023 rdf:first sg:person.01277357166.81
67 rdf:rest N5cfdb2a3cd894265bcc4bc6fddc0d254
68 N90a21ee5e0504389b3cad70cc689c41e schema:name dimensions_id
69 schema:value pub.1045098454
70 rdf:type schema:PropertyValue
71 N9a3205c2f4f248739b3ec289bc7cb96f schema:issueNumber 3
72 rdf:type schema:PublicationIssue
73 Na72fc3b12d2b4e14be9599bf4355ea8e schema:name doi
74 schema:value 10.2478/s13380-013-0133-2
75 rdf:type schema:PropertyValue
76 Nb55c83dacf434700990290548ca7320d rdf:first sg:person.0655662031.22
77 rdf:rest Necfa8cc825464f5eab0e243e05e5cdee
78 Nc96cb52def474885a08a43bf010b347a schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 Nd70ebe99d9e14f3f842d56ea47c8fcb4 rdf:first sg:person.01355053070.88
81 rdf:rest N3937bbc2af08471882cbe2cf40bdb4a3
82 Ne6114e642eb74f9f9bf920a436553f52 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
83 schema:familyName Gao
84 schema:givenName Jing
85 rdf:type schema:Person
86 Necfa8cc825464f5eab0e243e05e5cdee rdf:first sg:person.01162024270.12
87 rdf:rest N1230259a24f24c5ca7e053768d07f82d
88 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
89 schema:name Medical and Health Sciences
90 rdf:type schema:DefinedTerm
91 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
92 schema:name Neurosciences
93 rdf:type schema:DefinedTerm
94 sg:journal.1044565 schema:issn 2081-3856
95 2081-6936
96 schema:name Translational Neuroscience
97 rdf:type schema:Periodical
98 sg:person.01004430066.41 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
99 schema:familyName Xue
100 schema:givenName Rongliang
101 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004430066.41
102 rdf:type schema:Person
103 sg:person.01057427742.09 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
104 schema:familyName Wu
105 schema:givenName Gang
106 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057427742.09
107 rdf:type schema:Person
108 sg:person.01162024270.12 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
109 schema:familyName Li
110 schema:givenName Wei
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162024270.12
112 rdf:type schema:Person
113 sg:person.01231243766.51 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
114 schema:familyName Zhang
115 schema:givenName Zhenni
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231243766.51
117 rdf:type schema:Person
118 sg:person.01277357166.81 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
119 schema:familyName Lv
120 schema:givenName Jianrui
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277357166.81
122 rdf:type schema:Person
123 sg:person.01345472366.13 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
124 schema:familyName Lei
125 schema:givenName Xiaoming
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345472366.13
127 rdf:type schema:Person
128 sg:person.01355053070.88 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
129 schema:familyName Xue
130 schema:givenName Li
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355053070.88
132 rdf:type schema:Person
133 sg:person.0655662031.22 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
134 schema:familyName Fu
135 schema:givenName Rongguo
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655662031.22
137 rdf:type schema:Person
138 sg:pub.10.1007/s00210-005-1076-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001386324
139 https://doi.org/10.1007/s00210-005-1076-0
140 rdf:type schema:CreativeWork
141 sg:pub.10.1007/s11064-006-9248-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1005414923
142 https://doi.org/10.1007/s11064-006-9248-y
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/s11886-003-0085-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021631140
145 https://doi.org/10.1007/s11886-003-0085-1
146 rdf:type schema:CreativeWork
147 sg:pub.10.1097/00004647-199605000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022110693
148 https://doi.org/10.1097/00004647-199605000-00002
149 rdf:type schema:CreativeWork
150 sg:pub.10.1097/00004647-199906000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046284558
151 https://doi.org/10.1097/00004647-199906000-00005
152 rdf:type schema:CreativeWork
153 sg:pub.10.2119/2004-00032.aneja schema:sameAs https://app.dimensions.ai/details/publication/pub.1068964897
154 https://doi.org/10.2119/2004-00032.aneja
155 rdf:type schema:CreativeWork
156 https://app.dimensions.ai/details/publication/pub.1078357161 schema:CreativeWork
157 https://doi.org/10.1016/j.nbd.2008.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020029663
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.ncl.2005.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038479123
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.neuroscience.2004.06.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042287172
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/s0006-8993(03)03088-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003119186
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/s0361-9230(03)00139-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007318196
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/s0378-8741(02)00217-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041699953
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1038/sj.jcbfm.9600048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035752663
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1080/10408690390826464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011223761
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1089/089771502753754082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059201532
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1097/00004647-199605000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022110693
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1097/00004647-199906000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046284558
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1152/physiol.00015.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007450220
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1161/01.str.0000061888.71524.df schema:sameAs https://app.dimensions.ai/details/publication/pub.1007257809
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1161/01.str.0000083051.93319.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018697483
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1161/01.str.0000182238.08510.c5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047853452
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1161/hs0302.104542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047095766
188 rdf:type schema:CreativeWork
189 https://doi.org/10.3181/0703-mr-72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024340075
190 rdf:type schema:CreativeWork
191 https://www.grid.ac/institutes/grid.43169.39 schema:alternateName Xi'an Jiaotong University
192 schema:name Department of Anesthesia, Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, 710004, Xi’an, Shaanxi Province, P.R. China
193 Department of Nephrology, Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, 710004, Xi’an, P.R. China
194 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...