Antiproliferative activity of lichen extracts on murine myeloma cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-01-30

AUTHORS

Doriana Triggiani, Donatella Ceccarelli, Antonio Tiezzi, Tommaso Pisani, Silvana Munzi, Carlo Gaggi, Stefano Loppi

ABSTRACT

In the present study we report some preliminary results concerning the evaluation of antiproliferative activity on murine myeloma cells (P3X63-Ag8.653) of crude extracts of two common lichen species, Evernia prunastri and Xanthoria parietina. The results were evaluated by means of the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test, which is commonly used to assess the activity of living cells through mitochondrial dehydrogenases. They indicated that extracts of E. prunastri had no effect, while those of X. parietina significantly affected murine myeloma cell proliferation, with a reduction down to 75% for methanolic extracts. This opens perspectives for deeper investigations extended also to other mammalian cell lines. More... »

PAGES

59-62

References to SciGraph publications

  • 1997-09. Antimitotic effects of usnic acid on different biological systems in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2001-07. Pharmaceutically relevant metabolites from lichens in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1975-06. l-Usnic acid: Tumor inhibitor isolated from lichens in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2002-04. A review on usnic acid, an interesting natural compound in THE SCIENCE OF NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.2478/s11756-009-0005-y

    DOI

    http://dx.doi.org/10.2478/s11756-009-0005-y

    DIMENSIONS

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