Fasciola hepatica — the pilot study of in vitro assessing immune response against native and recombinant antigens of the fluke View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Piotr Bąska, Anna Zawistowska-Deniziak, Anna M. Zdziarska, Katarzyna Wasyl, Marcin Wiśniewski, Anna Cywińska, Maciej Klockiewicz, Kamil Januszkiewicz, Halina Wędrychowicz

ABSTRACT

Fasciola hepatica is a liver fluke that infects 2.4 million of people and causes great economical loss in animal production. To date a 100% effective vaccine has not been developed and the disease is controlled by drug therapy. Great efforts are put into development of effective vaccine against parasite what is difficult since Fasciola spp. (like other helmints) during evolutionary process has developed sophisticated and efficient methods to evade immune response. During preliminary experiments it is convenient to use cell lines which are relatively cheap and allow for reproducible comparison of results between laboratories. We stimulated BOMA (bovine monocyte/macrophage cell line) and BOMAC (bovine macrophage cell line) with native or recombinant antigens of Fasciola hepatica and assessed IFN-γ, IL-4 and TNF-α level upon stimulation. We observed diminished secretion of proinflammatory TNF-α in LPS activated BOMA cells stimulated with Excretory/Secretory products of adult fluke (Fh-ES). We also observed greater changes in gene expression in LPS activated BOMA cells than in non activated BOMA cells upon stimulation using Fh-ES. The results show possibility of using cell lines for in vitro research of bovine immune response against liver fluke, although this model still requires validation and further characterization. More... »

PAGES

453-462

Identifiers

URI

http://scigraph.springernature.com/pub.10.2478/s11686-013-0163-5

DOI

http://dx.doi.org/10.2478/s11686-013-0163-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049634297

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24338305


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2478/s11686-013-0163-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2478/s11686-013-0163-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2478/s11686-013-0163-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2478/s11686-013-0163-5'


 

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