Off-Label Prescribing in Older Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06

AUTHORS

Stephen H. D. Jackson, Paul A. F. Jansen, Arduino A. Mangoni

ABSTRACT

The practice of off-label prescribing, i.e. prescribing drugs either for unregistered/unapproved therapeutic indications and age groups or using unregistered/unapproved doses or methods of administration, is common in older patients. This may be due to the poor representation of this group in pre-marketing clinical trials assessing therapeutic efficacy and safety of novel therapies or merely to the fact that trials in a particular indication have not been undertaken. Off-label prescribing should not be viewed as scientifically or ethically unsound when there are good clinical data to support a particular therapeutic indication. However, a number of steps should be followed in order to ensure therapeutic efficacy, reducing, at the same time, the risk of adverse drug reactions and/or medical litigation. This article discusses the current epidemiology and trends in off-label prescribing in older patients, the scientific and ethical justification of this practice, medico-legal implications, and proposed strategies for risk mitigation. More... »

PAGES

427-434

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/11633520-000000000-00000

DOI

http://dx.doi.org/10.2165/11633520-000000000-00000

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030402968

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22642777


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