Cholinesterase Inhibitors and Adverse Pulmonary Events in Older People with Chronic Obstructive Pulmonary Disease and Concomitant Dementia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-03

AUTHORS

Anne Stephenson, Dallas P. Seitz, Hadas D. Fischer, Andrea Gruneir, Chaim M. Bell, Andrea S. Gershon, Longdi Fu, Geoff M. Anderson, Peter C. Austin, Paula A. Rochon, Sudeep S. Gill

ABSTRACT

BACKGROUND: Cholinesterase inhibitors (ChEIs) are a mainstay treatment for individuals with dementia. ChEIs may worsen airflow obstruction because of their pro-cholinergic properties. OBJECTIVE: The objective of this study was to evaluate the risk of serious pulmonary complications in the elderly with concomitant chronic obstructive pulmonary disease (COPD) and dementia who were receiving ChEIs. METHODS: This was a population-based, cohort study conducted between 2003 and 2010 in residents of Ontario, Canada. Subjects were over the age of 66 years and had concomitant dementia and COPD, identified using linked administrative databases. Exposure to ChEIs was determined using a drug benefits database. The primary outcome was an emergency room (ER) visit or hospitalization for COPD. The risk difference at 60 days and the relative risk (RR) for study outcomes were estimated in the propensity score-matched sample. RESULTS: Of 266,840 individuals with COPD, 45,503 had a concomitant diagnosis of dementia. A total of 7166 unexposed subjects were matched to subjects newly exposed to ChEIs. New users of ChEIs were not at significantly higher risk of ER visits or hospitalizations for COPD (RR 0.90; 95% CI 0.76, 1.07) or COPD exacerbations (RR 1.02; 95% CI 0.91, 1.15). Furthermore, ER visits for any respiratory diagnoses were not increased among new users of ChEIs (RR 1.02; 95% CI 0.87, 1.19) when compared with non-users. Sub-group analyses were consistent with the main analysis. CONCLUSIONS: In a large cohort of elderly individuals with COPD and dementia, new users of ChEIs had a similar risk for adverse pulmonary outcomes as those who were not receiving ChEIs. More... »

PAGES

213-223

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/11599480-000000000-00000

DOI

http://dx.doi.org/10.2165/11599480-000000000-00000

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020596242

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22332932


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2165/11599480-000000000-00000'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2165/11599480-000000000-00000'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2165/11599480-000000000-00000'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2165/11599480-000000000-00000'


 

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308 Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON, Canada
309 St Michael’s Hospital, 30 Bond Street, 6th Floor, M5B 1W8, Toronto, Ontario, Canada
310 Women’s College Research Institute, Women’s College Hospital, Toronto, ON, Canada
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.410356.5 schema:alternateName Queen's University
313 schema:name Department of Psychiatry, Queen’s University, Kingston, ON, Canada
314 St Mary’s of the Lake Hospital, Queen’s University, Kingston, ON, Canada
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.415502.7 schema:alternateName St. Michael's Hospital
317 schema:name St Michael’s Hospital, 30 Bond Street, 6th Floor, M5B 1W8, Toronto, Ontario, Canada
318 Women’s College Research Institute, Women’s College Hospital, Toronto, ON, Canada
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.418647.8 schema:alternateName Institute for Clinical Evaluative Sciences
321 schema:name Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
322 rdf:type schema:Organization
 




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