Long-Term Treatment of Severe SAPHO Syndrome with Adalimumab View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02

AUTHORS

Simone Garcovich, Rosanna Amelia, Nicola Magarelli, Venanzio Valenza, Pierluigi Amerio

ABSTRACT

SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome defines an association of inflammatory cutaneous disorders with osteoarticular manifestations and represents a clinical and therapeutic challenge. We report a case of severe SAPHO syndrome with acne conglobata and a diffuse involvement of the anterior chest wall and sacroiliac joints that required treatment with isotretinoin and adalimumab, a new fully human anti-tumor necrosis factor (TNF)-α monoclonal antibody. Combination treatment determined a complete clinical remission of cutaneous and osteoarticular manifestations after 48 weeks. Despite maintenance of clinical remission, follow-up imaging studies after 24 months of adalimumab monotherapy revealed osteoarticular disease progression, with features of inflammatory osteitis. TNFα antagonists have been used as third-line therapy for SAPHO syndrome in single case reports or case series, but these lack consistent long-term follow-up. SAPHO syndrome can present an intermittent-favorable course in the majority of cases as well as a chronic-progressive course, the latter requiring aggressive combination treatment with TNFα antagonists and conventional systemic agents. More... »

PAGES

55-59

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/11593250-000000000-00000

DOI

http://dx.doi.org/10.2165/11593250-000000000-00000

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049077034

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22007948


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