Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11

AUTHORS

Simone van Kralingen, Jeroen Diepstraten, Mariska Y. M. Peeters, Vera H. M. Deneer, Bert van Ramshorst, René J. Wiezer, Eric P. A. van Dongen, Meindert Danhof, Catherijne A. J. Knibbe

ABSTRACT

BACKGROUND AND OBJECTIVES: In view of the increasing prevalence of morbidly obese patients, the influence of excessive total bodyweight (TBW) on the pharmacokinetics and pharmacodynamics of propofol was characterized in this study using bispectral index (BIS) values as a pharmacodynamic endpoint. METHODS: A population pharmacokinetic and pharmacodynamic model was developed with the nonlinear mixed-effects modelling software NONMEM VI, on the basis of 491 blood samples from 20 morbidly obese patients (TBW range 98-167 kg) and 725 blood samples from 44 lean patients (TBW range 55-98 kg) from previously published studies. In addition, 2246 BIS values from the 20 morbidly obese patients were available for pharmacodynamic analysis. RESULTS: In a three-compartment pharmacokinetic model, TBW proved to be the most predictive covariate for clearance from the central compartment (CL) in the 20 morbidly obese patients (CL 2.33 L/min × [TBW/70]^[0.72]). Similar results were obtained when the morbidly obese patients and the 44 lean patients were analysed together (CL 2.22 L/min × [TBW/70]^[0.67]). No covariates were identified for other pharmacokinetic parameters. The depth of anaesthesia in the morbidly obese patients was adequately described by a two-compartment biophase-distribution model with a sigmoid maximum possible effect (E(max)) pharmacodynamic model (concentration at half-maximum effect [EC(50)] 2.12 mg/L) without covariates. CONCLUSION: We developed a pharmacokinetic and pharmacodynamic model of propofol in morbidly obese patients, in which TBW proved to be the major determinant of clearance, using an allometric function with an exponent of 0.72. For the other pharmacokinetic and pharmacodynamic parameters, no covariates could be identified. Trial registration number (clinicaltrials.gov): NCT00395681. More... »

PAGES

739-750

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/11592890-000000000-00000

DOI

http://dx.doi.org/10.2165/11592890-000000000-00000

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016217630

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21973271


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anesthetics, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Mass Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Consciousness Monitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity, Morbid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propofol", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Anesthesiology and Intensive Care, St Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Kralingen", 
        "givenName": "Simone", 
        "id": "sg:person.01321143171.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321143171.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diepstraten", 
        "givenName": "Jeroen", 
        "id": "sg:person.01204714571.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204714571.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peeters", 
        "givenName": "Mariska Y. M.", 
        "id": "sg:person.016133044542.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016133044542.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deneer", 
        "givenName": "Vera H. M.", 
        "id": "sg:person.0610517174.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610517174.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St Antonius Hospital, Nieuwegein, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Ramshorst", 
        "givenName": "Bert", 
        "id": "sg:person.0756446730.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756446730.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St Antonius Hospital, Nieuwegein, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiezer", 
        "givenName": "Ren\u00e9 J.", 
        "id": "sg:person.01155275674.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155275674.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Anesthesiology and Intensive Care, St Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Dongen", 
        "givenName": "Eric P. A.", 
        "id": "sg:person.01236550053.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236550053.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University", 
          "id": "https://www.grid.ac/institutes/grid.5132.5", 
          "name": [
            "Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Danhof", 
        "givenName": "Meindert", 
        "id": "sg:person.01361402042.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361402042.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University", 
          "id": "https://www.grid.ac/institutes/grid.5132.5", 
          "name": [
            "Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, the Netherlands", 
            "Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knibbe", 
        "givenName": "Catherijne A. J.", 
        "id": "sg:person.012736105417.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012736105417.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1067/mcp.2002.129500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001291627", 
          "https://doi.org/10.1067/mcp.2002.129500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2009.311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003683276", 
          "https://doi.org/10.1038/clpt.2009.311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200544100-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003951240", 
          "https://doi.org/10.2165/00003088-200544100-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200544100-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003951240", 
          "https://doi.org/10.2165/00003088-200544100-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2125.1999.00942.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004359924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/aeq195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005458159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199805000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007333592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199805000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007333592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199805000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007333592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/eja.0b013e328335468a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009438197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/eja.0b013e328335468a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009438197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.302.3.1158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010403127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cpt1979253358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010991170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199304000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015126644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199304000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015126644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.19381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016270965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.19381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016270965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/67.1.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018350497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/01.ane.0000252966.03103.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022720083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/01.ane.0000252966.03103.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022720083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/eja.0b013e328326f7d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023029794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/eja.0b013e328326f7d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023029794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/eja.0b013e328326f7d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023029794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200406000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023186539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200406000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023186539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199809000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023989660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199809000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023989660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199809000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023989660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)60318-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028703720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.295.13.1549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029260331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10928-010-9157-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030136443", 
          "https://doi.org/10.1007/s10928-010-9157-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10928-010-9157-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030136443", 
          "https://doi.org/10.1007/s10928-010-9157-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200039030-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030572913", 
          "https://doi.org/10.2165/00003088-200039030-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200039030-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030572913", 
          "https://doi.org/10.2165/00003088-200039030-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4347(97)00571-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034014856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-009-9873-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035767186", 
          "https://doi.org/10.1007/s11095-009-9873-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-009-9873-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035767186", 
          "https://doi.org/10.1007/s11095-009-9873-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.anes.0000278902.15505.f8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038067638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.anes.0000278902.15505.f8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038067638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11317150-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039413942", 
          "https://doi.org/10.2165/11317150-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11317150-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039413942", 
          "https://doi.org/10.2165/11317150-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11318100-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040691762", 
          "https://doi.org/10.2165/11318100-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11318100-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040691762", 
          "https://doi.org/10.2165/11318100-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/aem243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040946647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/aep143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043657865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01080870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043743580", 
          "https://doi.org/10.1007/bf01080870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0265021505001997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047574048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0265021505001997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047574048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0265021505001997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047574048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200003000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048936847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200003000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048936847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.2008.03112.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051119164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.clpt.6100381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052029518", 
          "https://doi.org/10.1038/sj.clpt.6100381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/01.ane.0000184038.49429.8f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064388385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/01.ane.0000184038.49429.8f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064388385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/01.ane.0000184038.49429.8f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064388385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/01.ane.0000184038.49429.8f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064388385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078449278", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-11", 
    "datePublishedReg": "2011-11-01", 
    "description": "BACKGROUND AND OBJECTIVES: In view of the increasing prevalence of morbidly obese patients, the influence of excessive total bodyweight (TBW) on the pharmacokinetics and pharmacodynamics of propofol was characterized in this study using bispectral index (BIS) values as a pharmacodynamic endpoint.\nMETHODS: A population pharmacokinetic and pharmacodynamic model was developed with the nonlinear mixed-effects modelling software NONMEM VI, on the basis of 491 blood samples from 20 morbidly obese patients (TBW range 98-167 kg) and 725 blood samples from 44 lean patients (TBW range 55-98 kg) from previously published studies. In addition, 2246 BIS values from the 20 morbidly obese patients were available for pharmacodynamic analysis.\nRESULTS: In a three-compartment pharmacokinetic model, TBW proved to be the most predictive covariate for clearance from the central compartment (CL) in the 20 morbidly obese patients (CL 2.33 L/min \u00d7 [TBW/70]^[0.72]). Similar results were obtained when the morbidly obese patients and the 44 lean patients were analysed together (CL 2.22 L/min \u00d7 [TBW/70]^[0.67]). No covariates were identified for other pharmacokinetic parameters. The depth of anaesthesia in the morbidly obese patients was adequately described by a two-compartment biophase-distribution model with a sigmoid maximum possible effect (E(max)) pharmacodynamic model (concentration at half-maximum effect [EC(50)] 2.12 mg/L) without covariates.\nCONCLUSION: We developed a pharmacokinetic and pharmacodynamic model of propofol in morbidly obese patients, in which TBW proved to be the major determinant of clearance, using an allometric function with an exponent of 0.72. For the other pharmacokinetic and pharmacodynamic parameters, no covariates could be identified. Trial registration number (clinicaltrials.gov): NCT00395681.", 
    "genre": "research_article", 
    "id": "sg:pub.10.2165/11592890-000000000-00000", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085321", 
        "issn": [
          "0312-5963", 
          "1179-1926"
        ], 
        "name": "Clinical Pharmacokinetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "50"
      }
    ], 
    "name": "Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients", 
    "pagination": "739-750", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4d45e84ce0b2f12c5978bbcd085924121eb6efbfc9dc12b6d69b582f2026ff12"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21973271"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7606849"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.2165/11592890-000000000-00000"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016217630"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.2165/11592890-000000000-00000", 
      "https://app.dimensions.ai/details/publication/pub.1016217630"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.2165%2F11592890-000000000-00000"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2165/11592890-000000000-00000'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2165/11592890-000000000-00000'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2165/11592890-000000000-00000'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2165/11592890-000000000-00000'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      73 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.2165/11592890-000000000-00000 schema:about N1312885914b9404eb1fae04218401963
2 N141083175c0a42f4b0128388ddefe164
3 N3b0b50d092784bcfac59370299919367
4 N57c5965b578648a9bbf43320d19584f7
5 N6838db1e3d8e4f9d954993fb0e9fb150
6 N916c88bc19844aa8a6401f2742cb1ef7
7 Na52b85b066214ed88a0ed48621619501
8 Na9e00e966c244d7693ccca60111699ef
9 Nbd72f6c4488a4255a3cea78e057b7ab5
10 Nc937450fb87d4c4e97620e879744812b
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N708461df703049abb7c2d827a7585169
14 schema:citation sg:pub.10.1007/bf01080870
15 sg:pub.10.1007/s10928-010-9157-1
16 sg:pub.10.1007/s11095-009-9873-7
17 sg:pub.10.1038/clpt.2009.311
18 sg:pub.10.1038/sj.clpt.6100381
19 sg:pub.10.1067/mcp.2002.129500
20 sg:pub.10.2165/00003088-200039030-00004
21 sg:pub.10.2165/00003088-200544100-00004
22 sg:pub.10.2165/11317150-000000000-00000
23 sg:pub.10.2165/11318100-000000000-00000
24 https://app.dimensions.ai/details/publication/pub.1078449278
25 https://doi.org/10.1001/jama.295.13.1549
26 https://doi.org/10.1002/cpt1979253358
27 https://doi.org/10.1016/s0140-6736(09)60318-4
28 https://doi.org/10.1016/s0378-4347(97)00571-9
29 https://doi.org/10.1017/s0265021505001997
30 https://doi.org/10.1046/j.1365-2125.1999.00942.x
31 https://doi.org/10.1093/bja/67.1.41
32 https://doi.org/10.1093/bja/aem243
33 https://doi.org/10.1093/bja/aep143
34 https://doi.org/10.1093/bja/aeq195
35 https://doi.org/10.1097/00000542-199304000-00008
36 https://doi.org/10.1097/00000542-199805000-00006
37 https://doi.org/10.1097/00000542-199809000-00004
38 https://doi.org/10.1097/00000542-200003000-00017
39 https://doi.org/10.1097/00000542-200406000-00006
40 https://doi.org/10.1097/01.anes.0000278902.15505.f8
41 https://doi.org/10.1097/eja.0b013e328326f7d0
42 https://doi.org/10.1097/eja.0b013e328335468a
43 https://doi.org/10.1111/j.1365-2125.2008.03112.x
44 https://doi.org/10.1124/jpet.302.3.1158
45 https://doi.org/10.1213/01.ane.0000184038.49429.8f
46 https://doi.org/10.1213/01.ane.0000252966.03103.89
47 https://doi.org/10.1345/aph.19381
48 schema:datePublished 2011-11
49 schema:datePublishedReg 2011-11-01
50 schema:description BACKGROUND AND OBJECTIVES: In view of the increasing prevalence of morbidly obese patients, the influence of excessive total bodyweight (TBW) on the pharmacokinetics and pharmacodynamics of propofol was characterized in this study using bispectral index (BIS) values as a pharmacodynamic endpoint. METHODS: A population pharmacokinetic and pharmacodynamic model was developed with the nonlinear mixed-effects modelling software NONMEM VI, on the basis of 491 blood samples from 20 morbidly obese patients (TBW range 98-167 kg) and 725 blood samples from 44 lean patients (TBW range 55-98 kg) from previously published studies. In addition, 2246 BIS values from the 20 morbidly obese patients were available for pharmacodynamic analysis. RESULTS: In a three-compartment pharmacokinetic model, TBW proved to be the most predictive covariate for clearance from the central compartment (CL) in the 20 morbidly obese patients (CL 2.33 L/min × [TBW/70]^[0.72]). Similar results were obtained when the morbidly obese patients and the 44 lean patients were analysed together (CL 2.22 L/min × [TBW/70]^[0.67]). No covariates were identified for other pharmacokinetic parameters. The depth of anaesthesia in the morbidly obese patients was adequately described by a two-compartment biophase-distribution model with a sigmoid maximum possible effect (E(max)) pharmacodynamic model (concentration at half-maximum effect [EC(50)] 2.12 mg/L) without covariates. CONCLUSION: We developed a pharmacokinetic and pharmacodynamic model of propofol in morbidly obese patients, in which TBW proved to be the major determinant of clearance, using an allometric function with an exponent of 0.72. For the other pharmacokinetic and pharmacodynamic parameters, no covariates could be identified. Trial registration number (clinicaltrials.gov): NCT00395681.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N3798a896be9f4f719975f45e5103762d
55 N687db76c0cbb4cf5af067a53322dea15
56 sg:journal.1085321
57 schema:name Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients
58 schema:pagination 739-750
59 schema:productId N02b084b7490e4cbbae59b91fe9055d32
60 N968ba0561a304e0486730c70c9c318f5
61 Nc697891e94394c5dbb1ad3be97f90f2d
62 Nde7db0303f72400c917a74d281cb14e5
63 Nfeca04815a8649d591331076a71c8ff8
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016217630
65 https://doi.org/10.2165/11592890-000000000-00000
66 schema:sdDatePublished 2019-04-10T16:40
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N5a3d7ffcea054ba8a9f9bc4a69ea3e71
69 schema:url http://link.springer.com/10.2165%2F11592890-000000000-00000
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N02b084b7490e4cbbae59b91fe9055d32 schema:name doi
74 schema:value 10.2165/11592890-000000000-00000
75 rdf:type schema:PropertyValue
76 N1312885914b9404eb1fae04218401963 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Body Mass Index
78 rdf:type schema:DefinedTerm
79 N141083175c0a42f4b0128388ddefe164 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Middle Aged
81 rdf:type schema:DefinedTerm
82 N1dddb38c0714482da57864d7c3d978d2 rdf:first sg:person.01155275674.37
83 rdf:rest Neef8ce89147f4b7da4712eae86a87f56
84 N3798a896be9f4f719975f45e5103762d schema:issueNumber 11
85 rdf:type schema:PublicationIssue
86 N3b0b50d092784bcfac59370299919367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Body Weight
88 rdf:type schema:DefinedTerm
89 N57c5965b578648a9bbf43320d19584f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Obesity, Morbid
91 rdf:type schema:DefinedTerm
92 N5a3d7ffcea054ba8a9f9bc4a69ea3e71 schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N6838db1e3d8e4f9d954993fb0e9fb150 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Male
96 rdf:type schema:DefinedTerm
97 N687db76c0cbb4cf5af067a53322dea15 schema:volumeNumber 50
98 rdf:type schema:PublicationVolume
99 N708461df703049abb7c2d827a7585169 rdf:first sg:person.01321143171.50
100 rdf:rest Ne3af9ca330254a3aaeda9a67c81619d3
101 N7103f4f1b12b4e1aac03daed2741edf6 rdf:first sg:person.01361402042.22
102 rdf:rest Nac9b336541a3439baab938c4bbe093e8
103 N916c88bc19844aa8a6401f2742cb1ef7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N9315908653f64912bcc7041834abde4a rdf:first sg:person.0610517174.93
107 rdf:rest Nff8f3cf238fe41d9bc753cb191e3b4fd
108 N968ba0561a304e0486730c70c9c318f5 schema:name pubmed_id
109 schema:value 21973271
110 rdf:type schema:PropertyValue
111 Na52b85b066214ed88a0ed48621619501 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Consciousness Monitors
113 rdf:type schema:DefinedTerm
114 Na9e00e966c244d7693ccca60111699ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Anesthetics, Intravenous
116 rdf:type schema:DefinedTerm
117 Nac9b336541a3439baab938c4bbe093e8 rdf:first sg:person.012736105417.27
118 rdf:rest rdf:nil
119 Nbd72f6c4488a4255a3cea78e057b7ab5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 Nc697891e94394c5dbb1ad3be97f90f2d schema:name dimensions_id
123 schema:value pub.1016217630
124 rdf:type schema:PropertyValue
125 Nc937450fb87d4c4e97620e879744812b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Propofol
127 rdf:type schema:DefinedTerm
128 Nd78a70ee954b49a99581acb95f14d3af rdf:first sg:person.016133044542.55
129 rdf:rest N9315908653f64912bcc7041834abde4a
130 Nde7db0303f72400c917a74d281cb14e5 schema:name nlm_unique_id
131 schema:value 7606849
132 rdf:type schema:PropertyValue
133 Ne3af9ca330254a3aaeda9a67c81619d3 rdf:first sg:person.01204714571.44
134 rdf:rest Nd78a70ee954b49a99581acb95f14d3af
135 Neef8ce89147f4b7da4712eae86a87f56 rdf:first sg:person.01236550053.11
136 rdf:rest N7103f4f1b12b4e1aac03daed2741edf6
137 Nfeca04815a8649d591331076a71c8ff8 schema:name readcube_id
138 schema:value 4d45e84ce0b2f12c5978bbcd085924121eb6efbfc9dc12b6d69b582f2026ff12
139 rdf:type schema:PropertyValue
140 Nff8f3cf238fe41d9bc753cb191e3b4fd rdf:first sg:person.0756446730.73
141 rdf:rest N1dddb38c0714482da57864d7c3d978d2
142 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
143 schema:name Medical and Health Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
146 schema:name Clinical Sciences
147 rdf:type schema:DefinedTerm
148 sg:journal.1085321 schema:issn 0312-5963
149 1179-1926
150 schema:name Clinical Pharmacokinetics
151 rdf:type schema:Periodical
152 sg:person.01155275674.37 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
153 schema:familyName Wiezer
154 schema:givenName René J.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155275674.37
156 rdf:type schema:Person
157 sg:person.01204714571.44 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
158 schema:familyName Diepstraten
159 schema:givenName Jeroen
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204714571.44
161 rdf:type schema:Person
162 sg:person.01236550053.11 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
163 schema:familyName van Dongen
164 schema:givenName Eric P. A.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236550053.11
166 rdf:type schema:Person
167 sg:person.012736105417.27 schema:affiliation https://www.grid.ac/institutes/grid.5132.5
168 schema:familyName Knibbe
169 schema:givenName Catherijne A. J.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012736105417.27
171 rdf:type schema:Person
172 sg:person.01321143171.50 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
173 schema:familyName van Kralingen
174 schema:givenName Simone
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321143171.50
176 rdf:type schema:Person
177 sg:person.01361402042.22 schema:affiliation https://www.grid.ac/institutes/grid.5132.5
178 schema:familyName Danhof
179 schema:givenName Meindert
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361402042.22
181 rdf:type schema:Person
182 sg:person.016133044542.55 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
183 schema:familyName Peeters
184 schema:givenName Mariska Y. M.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016133044542.55
186 rdf:type schema:Person
187 sg:person.0610517174.93 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
188 schema:familyName Deneer
189 schema:givenName Vera H. M.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610517174.93
191 rdf:type schema:Person
192 sg:person.0756446730.73 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
193 schema:familyName van Ramshorst
194 schema:givenName Bert
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756446730.73
196 rdf:type schema:Person
197 sg:pub.10.1007/bf01080870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043743580
198 https://doi.org/10.1007/bf01080870
199 rdf:type schema:CreativeWork
200 sg:pub.10.1007/s10928-010-9157-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030136443
201 https://doi.org/10.1007/s10928-010-9157-1
202 rdf:type schema:CreativeWork
203 sg:pub.10.1007/s11095-009-9873-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035767186
204 https://doi.org/10.1007/s11095-009-9873-7
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/clpt.2009.311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003683276
207 https://doi.org/10.1038/clpt.2009.311
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/sj.clpt.6100381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052029518
210 https://doi.org/10.1038/sj.clpt.6100381
211 rdf:type schema:CreativeWork
212 sg:pub.10.1067/mcp.2002.129500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001291627
213 https://doi.org/10.1067/mcp.2002.129500
214 rdf:type schema:CreativeWork
215 sg:pub.10.2165/00003088-200039030-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030572913
216 https://doi.org/10.2165/00003088-200039030-00004
217 rdf:type schema:CreativeWork
218 sg:pub.10.2165/00003088-200544100-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003951240
219 https://doi.org/10.2165/00003088-200544100-00004
220 rdf:type schema:CreativeWork
221 sg:pub.10.2165/11317150-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039413942
222 https://doi.org/10.2165/11317150-000000000-00000
223 rdf:type schema:CreativeWork
224 sg:pub.10.2165/11318100-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040691762
225 https://doi.org/10.2165/11318100-000000000-00000
226 rdf:type schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1078449278 schema:CreativeWork
228 https://doi.org/10.1001/jama.295.13.1549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029260331
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/cpt1979253358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010991170
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0140-6736(09)60318-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028703720
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0378-4347(97)00571-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034014856
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1017/s0265021505001997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047574048
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1046/j.1365-2125.1999.00942.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004359924
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/bja/67.1.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018350497
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1093/bja/aem243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040946647
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/bja/aep143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043657865
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1093/bja/aeq195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005458159
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1097/00000542-199304000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015126644
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1097/00000542-199805000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007333592
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1097/00000542-199809000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023989660
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1097/00000542-200003000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048936847
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/00000542-200406000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023186539
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/01.anes.0000278902.15505.f8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038067638
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/eja.0b013e328326f7d0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023029794
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/eja.0b013e328335468a schema:sameAs https://app.dimensions.ai/details/publication/pub.1009438197
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1365-2125.2008.03112.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051119164
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1124/jpet.302.3.1158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010403127
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1213/01.ane.0000184038.49429.8f schema:sameAs https://app.dimensions.ai/details/publication/pub.1064388385
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1213/01.ane.0000252966.03103.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022720083
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1345/aph.19381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016270965
273 rdf:type schema:CreativeWork
274 https://www.grid.ac/institutes/grid.415960.f schema:alternateName St. Antonius Ziekenhuis
275 schema:name Department of Anesthesiology and Intensive Care, St Antonius Hospital, Nieuwegein, The Netherlands
276 Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, the Netherlands
277 Department of Surgery, St Antonius Hospital, Nieuwegein, the Netherlands
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.5132.5 schema:alternateName Leiden University
280 schema:name Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, the Netherlands
281 Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden, the Netherlands
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...