Obesity Modifies the Association of Race/Ethnicity with Medication Adherence in the CARDIA Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

Maribel Salas, Catarina I. Kiefe, Pamela J. Schreiner, Yongin Kim, Lucia Juarez, Sharina D. Person, O. Dale Williams

ABSTRACT

OBJECTIVE: To assess associations between race/ethnicity and medication adherence, and the potential modifying effects of weight category (normal, overweight, obese) in a community-based sample. STUDY DESIGN AND SETTING: We studied 1355 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study who were taking prescription medications in 2000-1. Medication adherence, as rated on the four-item Morisky medication adherence scale (score of 4 = maximum adherence), was reported for all participants. RESULTS: The mean age ± SD of participants was 40 ± 3.6 years; 45% were African American and 36% were male. Overall, Whites had a higher proportion of maximum adherence than African Americans (59 vs 41%, respectively; p = 0.001). However, this difference was statistically significant only for participants within the normal weight category, of whom 54% of Whites were maximally adherent versus 35% of African Americans (p < 0.05). After adjustment for possible confounding covariates, race/ethnicity was associated with adherence only in those of normal weight: the odds ratio for maximum adherence in Whites versus African Americans of normal weight was 1.98 (95% CI 1.13, 3.47). Within race/ethnicity subgroups, weight category was associated with adherence in Whites but not in African Americans. CONCLUSION: Weight category modifies the association of race/ethnicity with medication adherence. The high levels of non-adherence observed among African Americans and obese and overweight Whites bodes poorly for treatment of obesity-associated diseases such as cardiovascular disease or diabetes mellitus. More... »

PAGES

41-54

References to SciGraph publications

  • 2007-03. Factors associated with adherence to drug therapy: a population-based study in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1994-02. Patient compliance and medical research in JOURNAL OF GENERAL INTERNAL MEDICINE
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.2165/01312067-200801010-00007

    DOI

    http://dx.doi.org/10.2165/01312067-200801010-00007

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030720036

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22272756


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