Therapeutic Potential of Monteplase in Acute Myocardial Infarction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-07

AUTHORS

Teruo Inoue, Ryoichi Nishiki, Manabu Kageyama, Koichi Node

ABSTRACT

Thrombolysis with conventional thrombolytic agents prior to percutaneous coronary intervention (PCI) has had no impact on the treatment of acute myocardial infarction (AMI). However, the development of mutant tissue type plasminogen activators (mt-PA) has prompted us to reassess the combination of thrombolysis and PCI. Monteplase is a newly developed mt-PA that can be administered as a single intravenous bolus injection. The results of the COMA (COmbining Monteplase with Angioplasty) trial, suggest that monteplase administration prior to emergent PCI in AMI improves 6-month outcomes and possibly the long-term prognosis of myocardial infarction. Combining monteplase administration on presentation at a community hospital with prompt transfer to a tertiary center for PCI would be an ideal strategy for the treatment of AMI. More... »

PAGES

225-231

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00129784-200505040-00002

DOI

http://dx.doi.org/10.2165/00129784-200505040-00002

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006425282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15984905


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