Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-08

AUTHORS

Thilo Gambichler, Markus Stücker, Katja Kerner, Stefan Weiner, Rüdiger Waldherr, Peter Altmeyer, Alexander Kreuter

ABSTRACT

Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously. We describe a patient with malignant melanoma, diffuse melanosis, and melanuria who developed acute kidney injury that was clinically indicated by an increase in urinary excreted metabolites in the serum. Histopathologic examination of kidney tissue revealed damage to tubules associated with disseminated intra-tubular melanin deposits. Diffuse melanosis with melanuria may lead to morphologic and functional kidney changes and warrants careful monitoring of kidney function in affected malignant melanoma patients. More... »

PAGES

267-270

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00128071-200809040-00007

DOI

http://dx.doi.org/10.2165/00128071-200809040-00007

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038248496

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18572978


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